Optical fiber sensor

• US 8,338,799 B2
• Filed: 07/24/2008
• Issued: 12/25/2012
• Est. Priority Date: 07/24/2007
• Status: Active Grant

• Current Assignee: Adelaide Research & Innovation Pty Ltd. (University of Adelaide)
• Original Assignee: Adelaide Research & Innovation Pty Ltd. (University of Adelaide)
• Inventors: Monro, Tanya, Ebendorff-Heidepriem, Heike, Smith, Stephen Warren, Vahid, Shahraam Afshar, Ruan, Yinlan
• Primary Examiner(s): Gaworecki, Mark R
• Application Number:
  US12/670,034
• Publication Number:
  US 20100237255A1
• Time in Patent Office: 1,615 Days
• Field of Search: 250/458.1, 250/459.1, 385/123, 385/125, 385/126, 385/127, 385/128
• US Class Current: 250/458.1
• CPC Class Codes: G01N 2021/0346 Capillary cells; Microcells
• CPC Class Codes: G01N 2021/6482 Sample cells, cuvettes
• CPC Class Codes: G01N 21/00 Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light G01N3/00 - G01N19/00 take precedence
• CPC Class Codes: G01N 21/0303 Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment G01N21/031 - G01N21/15 take precedence
• CPC Class Codes: G01N 21/648 using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
• CPC Class Codes: G01N 21/7703 using reagent-clad optical fibres or optical waveguides using measurement of total internal reflection or attenuated total reflection G01N21/552; optical fibres or waveguides per se G02B
• CPC Class Codes: G02B 6/0239 Comprising means for varying the guiding properties, e.g. tuning means

Abstract

A sensor based on optical fiber technology is described. The sensor includes an elongate core for propagating light having an excitation wavelength; an interaction region that includes a fluorescent material for excitation by the propagated light to produce fluorescent light; and an interface region defining a boundary between the elongate core and the interaction region. The elongate core of the sensor is adapted to increase an intensity of the propagated light at the interface region to increase the amount of captured fluorescent light in the elongate core.

Claims

1. A sensor including:

a micro structured optical fiber (MOF) including a solid core for propagating light having an excitation wavelength;

an interaction region surrounding or part surrounding the solid core, the interaction region incorporating a fluorescent material for excitation by the propagated light to produce fluorescent light; and

an interface region located between the solid core and the interaction region;

wherein the solid core is adapted to increase a discontinuity in the electromagnetic field of the propagated light at the interface region, thereby enhancing the intensity of the propagated light at the interface region.

2. A sensor as claimed in claim 1, wherein the solid core is adapted to increase a discontinuity in the electromagnetic field of the propagated light at the interface region by having a cross sectional dimension less than or of the same order as the excitation wavelength.

3. A sensor as claimed in claim 1, wherein the solid core is adapted to increase a discontinuity in the electromagnetic field of the propagated light at the interface region by selecting the solid core to have a refractive index greater than that of the interaction region.

4. A sensor as claimed in claim 3, wherein a difference in refractive index between the solid core and the interaction region is greater than 0.3.

5. A sensor as claimed in claim 4, wherein the difference in refractive index between the solid core and the interaction region is greater than 0.6.

6. A sensor as claimed in claim 5, wherein the difference in refractive index between the solid core and the interaction region is greater than 1.0.

7. A sensor as claimed in claim 1, wherein the captured fluorescent light is propagated along the solid core.

8. A sensor as claimed in claim 1, wherein the interaction region extends longitudinally along the solid core.

9. A sensor as claimed in claim 1, wherein the solid core is a nanowire supported by a support structure that defines the interaction region.

10. A sensor as claimed in claim 9, wherein the support structure attaches the solid core to a supportive outer jacket.

11. A sensor as claimed in claim 1, wherein the intensity of the propagated light at the interface region is greater than an intensity of the propagated light within the solid core.

12. A sensor as claimed in claim 11, wherein the intensity of the propagated light at the interface region is greater than the intensity of a peak value of the propagated light within the solid core.

13. A sensor as claimed in claim 1, wherein the interaction region is a containment region for containing the fluorescent material in liquid form.

14. A sensor as claimed in claim 13, wherein the containment region is fillable from a filling end of the sensor.

15. A sensor as claimed in claim 14, wherein the sensor is irradiated with light having the excitation wavelength at an input end of the sensor, the input end opposed to the filling end, and wherein fluorescent light is captured and propagated back towards the input end for detection.

16. A sensor as claimed in claim 1, wherein the interface region is exposed to the environment along the solid core.

17. A sensor as claimed in claim 16, wherein the interface region is exposed to the environment at a plurality of locations along the solid core.

18. A sensor as claimed in claim 1, wherein the interface region includes at least one portion coated with the fluorescent material.

19. A sensor as claimed in claim 18, wherein the fluorescent material is a fluorescently labeled antibody for the detection of a predetermined biomolecule.

20. A sensor as claimed in claim 1, wherein the interface region is coated by a fluorescent material at a plurality of locations spaced along the solid core.

21. A sensor as claimed in claim 20, wherein a plurality of different fluorescent materials are coated at the plurality of locations along the solid core.

22. A sensor as claimed in claim 1, wherein the interface region is exposed along the solid core.

23. A sensor as claimed in claim 1, wherein the interface region is partially exposed at locations corresponding to the plurality of locations where the interface region is coated.

24. A method for sensing including:

propagating light of an excitation wavelength down an solid core of a microstructured optical fibre (MOF) sensor, the sensor including an interaction region includes a fluorescent material;

enhancing an intensity of the propagated light at an interface region relative to an intensity of the propagated light within the solid core by increasing a discontinuity in the electromagnetic field of the propagated light at the interface region, the interface region located between the solid core and the interaction region to thereby increase the amount of captured fluorescent light in the solid core.

25. A method for sensing as claimed in claim 24, wherein the intensity of the propagated light at the interface region is greater than a peak intensity of propagated light within the solid core.

26. A method for sensing as claimed in claim 24, wherein the step of enhancing includes reducing the cross sectional dimension of the solid core to less than or of the same order as the excitation wavelength.

27. A method for sensing as claimed in claim 24, wherein the step of enhancing includes selecting the solid core to have a refractive index substantially greater than that of the interaction region.

28. A method for sensing as claimed in claim 24, further including propagating the captured fluorescent light along the solid core.

29. A sensor including:

a microstructured optical fiber (MOF) including a plurality of solid cores for propagating light having an excitation wavelength;

a plurality of interaction regions surrounding or part surrounding a respective solid core and incorporating fluorescent material for excitation by the propagated light to produce fluorescent light; and

corresponding interface regions located between each of the interaction regions and the respective solid cores, wherein a selection of the plurality of solid cores are adapted to increase a discontinuity in the electromagnetic field of the propagated light at the corresponding interface region, thereby enhancing the intensity of the propagated light at the corresponding interface region.

30. A sensor as claimed in claim 29, wherein the fluorescent material is varied over the plurality of interaction regions.