Method and a device for determining the hydration and/or nutrition status of a patient

• US 8,340,754 B2
• Filed: 12/21/2004
• Issued: 12/25/2012
• Est. Priority Date: 06/29/2004
• Status: Active Grant

• Current Assignee: Fresenius Medical Care Deutschland GmbH (Fresenius SE & Co. KGaA)
• Original Assignee: Fresenius Medical Care Deutschland GmbH (Fresenius SE & Co. KGaA)
• Inventors: Chamney, Paul, Wabel, Peter
• Primary Examiner(s): Hindenburg, Max
• Assistant Examiner(s): DANEGA, RENEE A
• Application Number:
  US11/630,965
• Publication Number:
  US 20080071147A1
• Time in Patent Office: 2,926 Days
• Field of Search: 600/300, 600/547
• US Class Current: 600/547
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content
• CPC Class Codes: A61B 5/1073 Measuring volume, e.g. of limbs
• CPC Class Codes: A61B 5/4869 Determining body composition
• CPC Class Codes: A61B 5/4872 Body fat
• CPC Class Codes: A61B 5/7278 Artificial waveform generation or derivation, e.g. synthesising signals from measured signals A61B5/327 takes precedence

Abstract

The invention relates to the field of monitoring the hydration and/or nutrition status of a patient. According to the invention a method is provided to determine at least one of a mal-hydration component, an adipose tissue component and a lean tissue component of a patient comprising the steps of determining chemical or physical properties of the patient and deriving the at least one component on the basis of the determined chemical or physical properties of the patient and previously determined values of a mass or volume fraction of water in lean tissue and a mass or volume fraction of water in adipose tissue. The invention also relates to a device for carrying out the method according to the invention and to a computer program product to be used on such a device.

Claims

1. A method to determine a mal-hydration component, an adipose tissue component, and a lean tissue component of a patient, the method comprising the steps of:

(a) determining chemical or physical properties of the patient;

wherein the chemical or physical properties of the patient are at least one of the whole body mass, the lipid mass and the total bone mineral content mass of the patient, and

(b) deriving the mal-hydration component, the adipose tissue component and the lean tissue component on the basis of the determined chemical or physical properties and previously determined patient-independent values of a mass or volume fraction of water in lean tissue and a mass or volume fraction of water in adipose tissue, wherein the mal-hydration component, the adipose tissue component and the lean tissue component is the mass or volume of the patient.

2. The method according to claim 1, characterised in that the chemical or physical properties of the patient further comprises the volume or mass of at least one of the total water, the extracellular water and the intracellular water of the patient.

3. The method according claim 1, characterised in that the previously determined values comprise the mass or volume fraction of the total water in lean tissue and the mass or volume fraction of the total water in adipose tissue.

4. The method according to claim 1, characterised in that the previously determined values comprise the mass or volume fraction of extracellular water in lean tissue and the mass or volume fraction of extracellular water in adipose tissue.

5. The method according claim 1, characterised in that the previously determined values comprise the mass or volume fraction of intracellular water in lean tissue and the mass or volume fraction of intracellular water in adipose tissue.

6. A device for carrying out a method to determine a mal-hydration component, an adipose tissue component, and a lean issue component of a patient, the method comprising the steps of:

(a) determining chemical or physical properties of the patient; and

(b) deriving the mal-hydration component, the adipose tissue component and the lean tissue component on the basis of the determined chemical or physical properties and previously determined patient-independent values of a mass or volume fraction of water in lean tissue and a mass or volume fraction of water in adipose tissue, wherein the mal-hydration component, the adipose tissue component and the lean tissue component is the mass or volume of the patient;

the device comprising

a measurement and/or input unit configured to provide values for the chemical or physical properties of the patient to be determined,

an evaluation unit configured to derive the mal-hydration component, the adipose tissue component and the lean tissue component on the basis of the determined properties of the patient and previously determined patient-independent values of a mass or volume fraction of water in lean tissue and a mass or volume fraction of water in adipose tissue, wherein the mal-hydration component, the adipose tissue component and the lean tissue component is the mass or volume of the patient, and

a communication link between the measurement and/or input unit and the evaluation unit.

7. The device according to claim 6, characterised in that the evaluation unit is also configured to control the measurement and/or input unit for determining at least one of the chemical or physical properties of the patient.

8. The device according to claim 6, characterised in that the evaluation unit is a microprocessor unit which in turn comprises a microprocessor program storage unit, wherein a program for deriving the at least one component on the basis of the determined chemical or physical properties of the patient and previously determined patient-independent values of a mass or volume fraction of water in lean tissue and a mass or volume fraction of water in adipose tissue is stored in the microprocessor program storage unit.

9. The device according to claim 8, characterised in that the program stored in the microprocessor storage unit also controls the measurement and/or input unit for determining at least one of the chemical or physical properties of the patient.

10. The device according claim 6, characterised in that the measurement unit comprises a bioimpedance measurement means to determine at least one of the chemical or physical properties of the patient.

11. The device according to claim 10, characterised in that the at least one of the chemical or physical properties of the patient comprise at least one of the extracellular water volume, the intracellular water volume or the total body water volume of the patient.

12. The device according to claim 6, characterised in that the measurement unit comprises scales to determine at least one of the chemical or physical properties of the patient.

13. The device according to claim 12, characterised in that the at least one of the chemical or physical properties is the whole body mass of the patient.

14. The device according to claim 6, characterised in that it further comprises an output unit linked to the evaluation unit for outputting any data derived by the evaluation unit.

15. A computer program product characterised in that it comprises a storage medium on which a microprocessor program to be stored in the microprocessor program storage unit of the device according to claim 8 is stored.