Making a liquid/liquid or gas system in microfluidics

• US 8,342,207 B2
• Filed: 09/22/2006
• Issued: 01/01/2013
• Est. Priority Date: 09/22/2005
• Status: Active Grant

• Current Assignee: Commissariat a L'Energie Atomique (French Alternative Energies and Atomic Energy Commission)
• Original Assignee: Commissariat a L'Energie Atomique (French Alternative Energies and Atomic Energy Commission)
• Inventors: Raccurt, Olivier, Fouillet, Yves
• Primary Examiner(s): Ball, J. Christopher
• Application Number:
  US12/066,840
• Publication Number:
  US 20090127123A1
• Time in Patent Office: 2,293 Days
• Field of Search: 204/279, 205/334, 137/806, 137/833
• US Class Current: 137/833
• CPC Class Codes: B01F 25/42 in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
• CPC Class Codes: B01F 33/30 Micromixers
• CPC Class Codes: G02B 3/14 of variable focal length
• CPC Class Codes: Y10T 137/2076 Utilizing diverse fluids
• CPC Class Codes: Y10T 137/2224 Structure of body of device

Abstract

The invention relates to a microfluidic device for making a liquid/liquid or gas biphasic system using a first liquid or a gas and a second liquid, non-miscible with each other, the device having a first hydrophobic surface for the second liquid, the first liquid forming a layer (6) on said first hydrophobic surface. The device comprises means for introducing a drop (7) of the second liquid into the layer of first liquid or gas and in contact with said first hydrophobic surface, and means for displacing the drop on said first hydrophobic surface along a determined path, the device having on the path of the drop, at least one wetting defect causing, upon passing of the drop over this defect, failure of the triple line of contact of the drop on the first hydrophobic surface and inclusion of first liquid (8) or gas into the drop.

The invention also relates to the associated method.

Claims

1. A microfluidic device for making a liquid/liquid or liquid/gas biphasic system using a first liquid or a first gas, and a second liquid, non-miscible with each other, the device comprising:

a first hydrophobic surface,

a layer of the first liquid or the first gas on said first hydrophobic surface,

a second hydrophobic surface positioned facing the first hydrophobic surface so as to form a closed or confined system for the first liquid or the first gas layer,

a drop of the second liquid on said first hydrophobic surface and in the layer of the first liquid or the first gas and at a location along a determined path,

a displacer to place the drop of the second liquid on said first hydrophobic surface along the determined path, and

at least one wetting defect on the determined path, wherein the wetting defect causes, upon the passing of the drop of the second liquid on this defect, failure of a triple line of contact of the drop of the second liquid on the first hydrophobic surface and inclusion of an amount of the first liquid or the first gas in the drop of the second liquid,

wherein the displacer is an electrical activation device that provides an electro-wetting effect.

2. The microfluidic device according to claim 1, wherein the electrical activation device comprises a counter-electrode comprised in or deposited on an insulating support, a surface of which forms the second hydrophobic surface, the counter-electrode being positioned along said determined path.

3. A method for making a liquid/liquid or liquid/gas biphasic system using a first liquid or a first gas, and a second liquid, non-miscible with each other, comprising:

forming a first liquid layer or a first gas layer on a first hydrophobic surface,

introducing a drop of the second liquid within the first liquid layer or the first gas layer such that the drop of the second liquid is in contact with said first hydrophobic surface,

displacing the drop of the second liquid on said first hydrophobic surface along a determined path so that the drop of the second liquid encounters at least one wetting defect, and upon passing of the drop of the second liquid over the defect, failure of a triple line of contact of the drop of the second liquid on the first hydrophobic surface and inclusion of the first liquid or the first gas in the drop of the second liquid occurs.

4. The method according to claim 3, wherein the displacement of the drop of the second liquid is obtained by electrical activation providing an electro-wetting effect.

5. The method according to claim 4, wherein the electrical activation is provided by a succession of electrodes positioned along said determined path.

6. The method according to claim 3, wherein the displacement of the drop of the second liquid is obtained by mechanical action on the drop of the second liquid.

7. The method according to claim 3, wherein the first liquid layer of the first gas layer is formed between said first hydrophobic surface and a second hydrophobic surface positioned facing the first hydrophobic surface so as to form a closed or confined system for the first liquid layer or the first gas layer.

8. The method according to claim 7, wherein the first liquid and a third liquid are formed between the first hydrophobic surface and the second hydrophobic surface, said third liquid being non-miscible with the first liquid and the second liquid.

9. The method according to claim 8, wherein the displacing of the drop of the second liquid along the determined path causes the drop of the second liquid to encounter at least one wetting defect which causes inclusion of the first liquid, and causes the drop of the second liquid to encounter at least one wetting defect which causes inclusion of the third liquid.

10. The method according to claim 9, wherein the first liquid and the second liquid are formed in succession in the biphasic system.

11. The method according to claim 9, wherein the first liquid and the second liquid are formed in superposition in the biphasic system.

12. A microfluidic device for making a liquid/liquid or liquid/gas biphasic system using a first liquid or a first gas, and a second liquid, non-miscible with each other, the device comprising:

a first hydrophobic surface,

a layer of the first liquid or the first gas on said first hydrophobic surface,

a drop of the second liquid on said first hydrophobic surface and in the layer of the first liquid or the first gas and at a location along a determined path,

a displacer to place the drop of the second liquid on said first hydrophobic surface along the determined path, and

at least one wetting defect on the determined path, wherein the wetting defect causes, upon the passing of the drop of the second liquid on this defect, failure of a triple line of contact of the drop of the second liquid on the first hydrophobic surface and inclusion of an amount of the first liquid or the first gas in the drop of the second liquid,

wherein the displacer is a device that exerts mechanical action on the drop of the second liquid.

13. The microfluidic device according to claim 12, wherein the device that exerts mechanical action on the drop of the second liquid comprises a pump.

14. The microfluidic device according to claim 12, wherein the wetting defect is a topological defect present on the first hydrophobic surface.

15. The microfluidic device according to claim 14, wherein the topological defect is a defect selected from the group consisting of a protrusion, a hole and a rough area.

16. The microfluidic device according to claim 12, wherein the wetting defect is a wetting defect of the first hydrophobic surface.

17. The microfluidic device according to claim 12, wherein the wetting defect is a permanent defect produced on the first hydrophobic surface or a momentary defect caused on the first hydrophobic surface.

18. The microfluidic device according to claim 12, comprising a second hydrophobic surface positioned facing the first hydrophobic surface so as to form a closed or confined system for the first liquid or the first gas layer.

19. A microfluidic device for making a liquid/liquid or liquid/gas biphasic system using a first liquid or a first gas, and a second liquid, non-miscible with each other, the device comprising:

a first hydrophobic surface,

a layer of the first liquid or the first gas on said first hydrophobic surface,

a drop of the second liquid on said first hydrophobic surface and in the layer of the first liquid or the first gas and at a location along a determined path,

a displacer to place the drop of the second liquid on said first hydrophobic surface along the determined path, and

at least one wetting defect on the determined path, wherein the wetting defect causes, upon the passing of the drop of the second liquid on this defect, failure of a triple line of contact of the drop of the second liquid on the first hydrophobic surface and inclusion of an amount of the first liquid or the first gas in the drop of the second liquid,

wherein a second hydrophobic surface is positioned facing the first hydrophobic surface so as to form a closed or confined system for the drop of second liquid, the first hydrophobic surface and the second hydrophobic surface also confine said first liquid and a third liquid, non-miscible with each other, the second hydrophobic surface also has a wetting defect positioned relative to the wetting defect of the first hydrophobic surface, to the first liquid and to the third liquid so that the passing of the drop of the second liquid on the wetting defects causes inclusion of the first liquid and inclusion of the third liquid in the drop of the second liquid.

20. The microfluidic device according to claim 19, wherein the first liquid and the third liquid are positioned in succession in the device, relatively to the passing of the drop of the second liquid, the first liquid being in contact with the wetting defect of the first hydrophobic surface, the third liquid being in contact with the wetting defect of the second hydrophobic surface.

21. The microfluidic device according to claim 19, wherein the first liquid and the third liquid are positioned, superposed in the device, the drop of the second liquid simultaneously passing into the first liquid and the third liquid, the first liquid being in contact with the wetting defect of the first hydrophobic surface, the third liquid being in contact with the wetting defect of the second hydrophobic surface.

22. A microfluidic device for making a liquid/liquid or liquid/gas biphasic system using a first liquid or a first gas, and a second liquid, non-miscible with each other, the device comprising:

a first hydrophobic surface,

a layer of the first liquid or the first gas on said first hydrophobic surface,

a drop of the second liquid on said first hydrophobic surface and in the layer of the first liquid or the first gas and at a location along a determined path,

a displacer to place the drop of the second liquid on said first hydrophobic surface along the determined path, and

at least one wetting defect on the determined path, wherein the wetting defect causes, upon the passing of the drop of the second liquid on this defect, failure of a triple line of contact of the drop of the second liquid on the first hydrophobic surface and inclusion of an amount of the first liquid or the first gas in the drop of the second liquid,

wherein the displacer is an electrical activation device that provides an electro-wetting effect, said electrical activation device comprising a succession of electrodes comprised in or on a support having a dielectric layer, a surface of which forms the first hydrophobic surface, the succession of electrodes being positioned along said determined path, and

wherein the at least one wetting defect is formed by a hole in one of the electrodes of the succession of electrodes.

23. The microfluidic device according to claim 22, comprising several holes in one of the electrodes, the holes forming as many wetting defects and being positioned according to a matrix arrangement.

24. A microfluidic device for making a liquid/liquid or liquid/gas biphasic system using a first liquid or a first gas, and a second liquid, non-miscible with each other, the device comprising:

a first hydrophobic surface,

a layer of the first liquid or the first gas on said first hydrophobic surface,

a drop of the second liquid on said first hydrophobic surface and in the layer of the first liquid or the first gas and at a location along a determined path,

a displacer to place the drop of the second liquid on said first hydrophobic surface along the determined path, and

at least one wetting defect on the determined path, wherein the wetting defect causes, upon the passing of the drop of the second liquid on this defect, failure of a triple line of contact of the drop of the second liquid on the first hydrophobic surface and inclusion of an amount of the first liquid or the first gas in the drop of the second liquid,

wherein the displacer is an electrical activation device that provides an electro-wetting effect, said electrical activation device comprising a succession of electrodes comprised in or on a support having a dielectric layer, a surface of which forms the first hydrophobic surface, the succession of electrodes being positioned along said determined path, and

wherein the at least one wetting defect is formed by an additional electrode positioned inside one of the electrodes of the succession of electrodes and without any electric contact therewith.

25. The microfluidic device according to claim 24, comprising several additional electrodes inside one of said electrodes and without any electric contact therewith, said additional electrodes forming as many wetting defects and being positioned according to a matrix arrangement.