Optical vital sign detection method and measurement device

• US 8,343,063 B2
• Filed: 05/23/2007
• Issued: 01/01/2013
• Est. Priority Date: 05/24/2006
• Status: Active Grant

• Current Assignee: Tarilian Laser Technologies, Limited (Huma Therapeutics Ltd.)
• Original Assignee: Tarilian Laser Technologies, Limited (Huma Therapeutics Ltd.)
• Inventors: Borgos, John
• Primary Examiner(s): Kahelin, Michael
• Assistant Examiner(s): TRAN, THO Q
• Application Number:
  US11/752,756
• Publication Number:
  US 20070287927A1
• Time in Patent Office: 2,050 Days
• Field of Search: 600/41, 600/490, 600/500, 356/450, 356/498, 356/486, 356/482, 356/614, 738/00
• US Class Current: 600/490
• CPC Class Codes: A61B 2562/0266 Optical strain gauges
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02225 using the oscillometric method
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/02422 within occluders
• CPC Class Codes: A61B 5/11 Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb for measuring pulse A61B5/02 ;A61B5/1038 takes precedence; motion detection to correct for motion artifacts in physiological signals A61B5/721

Abstract

A vital sign measurement device includes a sensor fixation device, an optical sensing system, and an output unit. The sensor fixation device is adapted to be placed against an anatomical location of a subject, within which is an artery. The optical sensing system includes an optical source device and an optical detector, both of which are held by the sensor fixation device and move with movement of the sensor fixation device. The optical source device is configured to produce a speckle pattern output. The optical detector is positioned to detect at least a portion of the speckle pattern output and generate therefrom the detected portion of the speckle pattern output. The optical sensing system can sense an arterial pulse from the movement, bending, or compression of at least one portion of the optical sensing system relative to other portions of the optical sensing system resulting in a change in the optical signal received within the detected portion of the speckle pattern output. The output unit generates a measure of the vital sign using a signal indicative of the optical signal received within the detected portion of the speckle pattern output.

Claims

1. A vital sign measurement device comprising:

a sensor fixation device adapted to be placed against an anatomical location of a subject, within which is an artery;

an optical sensing system comprising an optical source device and an optical detector, both of which are held by the sensor fixation device and move with movement of the sensor fixation device, the optical source device configured to produce a speckle pattern output, the optical detector positioned to detect at least a portion of the speckle pattern output and generate therefrom a signal indicative of the detected portion of the speckle pattern output;

a sensor pad held by the sensor fixation device on a cantilevered beam so that it is placed against the anatomical location when the sensor fixation device is placed against the anatomical location, wherein the sensor pad on the cantilevered beam is attached to or presses against at least one portion of the optical sensing system such that an arterial pulse results in the movement, bending, or compression of the at least one portion of the optical sensing system relative to other portions of the optical sensing system resulting in a change in an optical energy received within the detected portion of the speckle pattern output, wherein the optical detector comprises an optical energy receiving portion having a smaller surface area than the area of the speckle pattern output; and

an output unit that generates a measure of the vital sign using the signal indicative of the optical signal received within the detected portion of the speckle pattern output.

2. The vital sign measurement device of claim 1, wherein the sensor fixation device is an inflatable cuff.

3. The vital sign measurement device of claim 1, further comprising a pressure sensor to detect a pressure applied to the anatomical location, wherein the output unit receives, from the pressure sensor, a pressure input indicative of the pressure applied to the anatomical location, wherein the output unit generates the vital sign using the signal indicative of the optical signal received within the detected portion of the speckle pattern output and the pressure input.

4. The vital sign measurement device of claim 1, wherein the anatomical location of the subject is an upper arm, and the sensor fixation device is configured so that the optical sensing system is positionable to sense movement due to a pulse of a brachial artery.

5. The vital sign measurement device of claim 1, wherein the optical source device comprises an optical source and a diffuser that diffuses an optical signal produced by the optical source to produce the speckle pattern output.

6. The vital sign measurement device of claim 5, wherein the diffuser comprises polyoxymethylene, a white fluoropolymer, polyamide, or a combination thereof.

7. The vital sign measurement device of claim 5, wherein the optical signal travels through a portion of the diffuser having a thickness of between 0.2 mm and 1.0 mm.

8. The vital sign measurement device of claim 1, wherein the optical source device comprises an optical source and a mirror with surface imperfections that refracts an optical signal produced by the optical source to produce the speckle pattern output.

9. The vital sign measurement device of claim 1, further comprising:

a spatial optical occluder adapted to prevent the optical detector from receiving a portion of the speckle pattern output.

10. The vital sign measurement device of claim 9, wherein the spatial optical occluder is a blocking structure having an optical aperture formed therein.

11. The vital sign measurement device of claim 1, wherein the detected portion of the speckle pattern output is less than 100 times an area of an average speckle of the speckle pattern output.

12. The vital sign measurement device of claim 1, wherein the detected portion of the speckle pattern output is between 1 and 25 times the area of an average speckle of the speckle pattern output.

13. The vital sign measurement device of claim 1, wherein the optical source comprises a coherent light source.

14. The vital sign measurement device of claim 1, wherein the optical detector comprises a plurality of optical detection regions, each optical detection region adapted to receive optical energy from the speckle pattern output from a plurality of detected regions of the speckle pattern output.

15. The vital sign measurement device of claim 1, wherein the optical detector is a CCD or CMOS detector.

16. The vital sign measurement device of claim 1, wherein the vital sign is at least one of a heart rate, an arterial pulse waveform, a systolic blood pressure, a diastolic blood pressure, a mean arterial blood pressure, a pulse pressure, or an arterial compliance.

17. The vital sign measurement device of claim 1, further comprising a spring attached to at least a portion of the optical sensing system to counter a force from the arterial pulse and to return the optical sensing system to an initial state after the arterial pulse.

18. The vital sign measurement device of claim 1, further comprising a sensor pad held by the sensor fixation device adjacent to the anatomical location, wherein modulation of the sensor pad results in relative movement, compression, or bending of portions of the optical source device that result in a modulation of the speckle pattern output.

19. The vital sign measurement device of claim 1, wherein the optical sensing system is adapted to sense a pulse amplitude of the arterial pulse from the movement, bending, or compression of at least one portion of the optical sensing system relative to other portions of the optical sensing system resulting in a series of changes in the detected portion of the speckle pattern output.

20. The vital sign measurement device of claim 19, wherein the optical sensing system is configured to detect optical signals representative of a series of arterial pulses and the output unit is adapted to determine a pulse waveform for each of the series of arterial pulses.

21. A vital sign measurement device comprising:

a sensor fixation device adapted to be placed against an anatomical location of a subject, within which is an artery;

an optical sensing system comprising an optical source, a diffuser, and an optical detector, at least one of the optical source, the diffuser, and the optical detector held by the sensor fixation device and adapted to move in response to an arterial pulse relative to at least one of the other components of the optical sensing system, the optical source and the diffuser configured to produce a speckle pattern output, the optical detector positioned to detect a portion of the speckle pattern output and generate therefrom a signal indicative of optical energy received within the detected portion of the speckle pattern output, wherein at least a portion of the optical sensing system is positioned on a cantilevered support; and

an output unit that generates a measure of the vital sign using the generated signal indicative of optical energy received within the detected portion of the speckle pattern output.