Clotting cascade initiating apparatus and methods of use and methods of closing wounds
First Claim
1. A method for treating a wound in a patient comprising:
- withdrawing unanticoagulated whole blood from the patient into a first container, wherein the first container is a syringe or a blood vial;
anticoagulating the unanticoagulated whole blood in the first container to generate anticoagulated blood;
reversing anticoagulation in at least a portion of the anticoagulated blood in a second container to generate reversed blood, wherein the reversed blood is capable of clot formation; and
treating the wound with at least a portion of the reversed blood, wherein the treating comprises transferring the portion of the reversed blood from the second container to the patient without passing through the first container.
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Accused Products
Abstract
A wound closure apparatus and associated methods are provided which utilize blood fluid by activating the clotting cascade of blood fluid within a substantially enclosed sterile container then introducing the blood fluid to the wound site to complete clotting. An apparatus for providing ways of inhibiting anticoagulating agents and slowing fibrin clot degradation are also disclosed. Kits are also disclosed. The invention provides a clotting cascade initiation apparatus including a substantially enclosed sterile containment chamber within which an aliquot of blood fluid, either autologous or from donor sources, can be received and retained. In preferred embodiments, the sterile containment chamber further includes a heparin binding agent which will bind heparin and remove it from the blood fluid. In further embodiments, the containment chamber will also include a procoagulating agent, wherein a clotting cascade can be initiated when the blood fluid is accepted into the sterile containment chamber.
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Citations
37 Claims
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1. A method for treating a wound in a patient comprising:
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withdrawing unanticoagulated whole blood from the patient into a first container, wherein the first container is a syringe or a blood vial; anticoagulating the unanticoagulated whole blood in the first container to generate anticoagulated blood; reversing anticoagulation in at least a portion of the anticoagulated blood in a second container to generate reversed blood, wherein the reversed blood is capable of clot formation; and treating the wound with at least a portion of the reversed blood, wherein the treating comprises transferring the portion of the reversed blood from the second container to the patient without passing through the first container. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A method for treating a wound in a patient comprising:
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withdrawing whole blood from the patient into a first container, wherein the first container is a syringe or a blood vial; anticoagulating the whole blood in the first container to generate anticoagulated blood; reversing anticoagulation in at least a portion of the anticoagulated blood in a second container to generate reversed blood, wherein the reversed blood is capable of clot formation; and treating the wound with at least a portion of the reversed blood, wherein the treating comprises transferring the portion of the reversed blood from the second container to the patient without passing through the first container. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34)
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35. A method for treating a wound in a patient comprising:
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withdrawing whole blood from the patient into a first container, wherein the first container is a syringe or a blood vial; anticoagulating the whole blood in the first container to generate anticoagulated blood; reversing anticoagulation in at least a portion of the anticoagulated blood in a second container to generate reversed blood, wherein the reversed blood is capable of clot formation; initiating a clotting cascade in the reversed blood during a first time period such that at least a portion of the reversed blood will form a clot during a second time period subsequent to the first time period; and treating the wound with at least a portion of the reversed blood, wherein the treating comprises transferring the portion of the reversed blood from the second container to the patient without passing through the first container. - View Dependent Claims (36, 37)
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Specification