Systems and methods for intravascular cooling
First Claim
1. A device, comprising:
- an insertion device adapted to fluidicly communicate with a source of an infusate; and
a controller adapted to control a temperature of the infusate, in accordance with a temperature of a blood and infusate mixture downstream of an infusate exit location of the insertion device while the insertion device is placed in a blood vessel of a patient with a downstream flow of blood for infusion of the infusate, and control at least one of (a) an infusion rate of the infusate through the insertion device, and (b) a volume of the infusate passing through the insertion device in a downstream direction, in accordance with a native vessel flow rate in the blood vessel.
2 Assignments
0 Petitions
Accused Products
Abstract
Methods and systems for infusing a cooled infusate to a target location in a patient are described. A temperature of the blood and infusate admixture upstream of the catheter as well as at other locations along the catheter may be monitored and a feedback system utilized to control the volume, temperature, and/or infusion rate of the infusate so as to achieve a predetermined temperature at the target location. Control may also be based on the patient'"'"'s native vessel flow rate. The system may monitor or calculate hematocrit upstream of the catheter and adjust infusion so as to provide sufficient oxygenation of the blood and infusate admixture. The system may also monitor reflux of the infusate past a distal end of the catheter and reduce infusion upon the detection of reflux.
123 Citations
67 Claims
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1. A device, comprising:
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an insertion device adapted to fluidicly communicate with a source of an infusate; and a controller adapted to control a temperature of the infusate, in accordance with a temperature of a blood and infusate mixture downstream of an infusate exit location of the insertion device while the insertion device is placed in a blood vessel of a patient with a downstream flow of blood for infusion of the infusate, and control at least one of (a) an infusion rate of the infusate through the insertion device, and (b) a volume of the infusate passing through the insertion device in a downstream direction, in accordance with a native vessel flow rate in the blood vessel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 40, 42, 43, 44)
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26. A device, comprising:
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an insertion device adapted to fluidicly communicate with a source of an infusate; a plurality of sensors; and a controller adapted to receive signals from the sensors indicative of a native vessel flow rate in a blood vessel in which the insertion device is inserted and to control at least one of an infusion rate of the infusate flowing through the insertion device, and a volume of the infusate passing through the insertion device, in accordance with the signals from the sensors. - View Dependent Claims (27, 28, 29, 45, 46)
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30. A device, comprising:
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an elongate sensor support device adapted to be inserted into a patient and having one or more sensors connected to it along its length; and a controller adapted to receive signals from the sensors and control at least one of (a) at least one parameter of an infusate infused into the patient through an insertion device in a downstream direction, (b) an infusion rate of the infusate, and (c) a volume of the infusate, in accordance with at least one parameter of a blood and infusate mixture downstream relative to an infusate exit location of the insertion device while the insertion device is placed in a blood vessel of a patient with a downstream flow of blood for infusion of the infusate, and control at least one of (a) an infusion rate of the infusate through the insertion device, and (b) a volume of the infusate passing through the insertion device in a downstream direction in accordance with a native vessel flow rate in the blood vessel. - View Dependent Claims (31, 47, 48)
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32. A device, comprising:
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an elongate sensor support device adapted to be inserted into a patient and having one or more sensors connected to it along its length; and a controller adapted to receive signals from the sensors and control at least one of (a) at least one parameter of an infusate infused into the patient through an insertion device in a first direction, (b) an infusion rate of the infusate, and (c) a volume of the infusate, in accordance with at least one parameter of a blood and infusate mixture at a first position, said first position adjacent an infusate exit location on the insertion device and spaced a distance away from the infusate exit location along a second direction opposite the first direction, and control at least one of (a) an infusion rate of the infusate through the insertion device, and (b) a volume of the infusate passing through the insertion device, in accordance with a native vessel flow rate in the blood vessel. - View Dependent Claims (33, 49, 50)
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34. A device, comprising:
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an insertion device adapted to fluidicly communicate with a source of an infusate and be positioned in a system filled with at least one of a fluid and gas flowing in a first direction; a sensor located exterior to an internal lumen of the insertion device, the sensor located a distance away from an infusate exit location of the insertion device along a second direction opposite the first direction; and a controller adapted to receive signals from the sensor indicative of at least one parameter of at least one of the fluid and gas to control at least one of (a) at least one parameter of the infusate, (b) an infusion rate of the infusate through the insertion device, and (c) a volume of the infusate passing through the insertion device in accordance with the signals from the sensor and control at least one of (a) an infusion rate of the infusate through the insertion device, and (b) a volume of the infusate passing through the insertion device in a downstream direction in accordance with a native vessel flow rate in the blood vessel. - View Dependent Claims (35, 36, 37, 38, 39, 51)
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41. A device, comprising:
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an insertion device adapted to fluidicly communicate with a source of an infusate and to be placed in a blood vessel; and a controller adapted to control at least one of (a) a temperature of the infusate, (b) an infusion rate of the infusate through the insertion device into the blood vessel, and (c) a volume of the infusate passing through the insertion device in a downstream direction into the blood vessel, and control at least one of (a) an infusion rate of the infusate through the insertion device, and (b) a volume of the infusate passing through the insertion device in a downstream direction in accordance with a native vessel blood flow rate in the blood vessel. - View Dependent Claims (52, 53)
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54. A device, comprising:
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an insertion device; a plurality of temperature sensors comprising a first temperature sensor positioned downstream relative to an infusate exit location of the insertion device and adapted to measure a temperature of an infusate and blood mixture when the insertion device is placed in a blood vessel of a patient for infusion of the infusate, a second temperature sensor adapted to measure a temperature of the infusate at least one of at and adjacent the exit location, a third temperature sensor adapted to measure a temperature outside the insertion device upstream and adjacent the exit location, and a fourth temperature sensor adapted to measure a core body temperature of the patient; and a controller adapted to receive signals from the temperature sensors and control a characteristic of the infusate, in accordance with signals received from at least one of the plurality of temperature sensors. - View Dependent Claims (55, 56)
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57. A device, comprising:
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an insertion device; and a controller adapted to control at least one of (a) an infusion rate of the infusate through the insertion device and (b) a volume of infusate passing through the insertion device in accordance with a hematocrit of a blood and infusate mixture downstream of an exit location of the insertion of device, wherein hematocrit is calculated downstream the exit location using the equation (Hct)*(1−
dF), wherein dF=(infusion rate)/(infusion rate+X), wherein X is an amount of blood per unit time at the core body temperature in the blood and infusate mixture and is represented by the equation X=(infusion rate*(T1−
T2)/(T4−
T1)), T1 is a temperature of the blood and infusate mixture downstream the exit location, T2 is a temperature of the infusate at least one of at and adjacent the exit location, T3 is temperature adjacent to and upstream the exit location, and T4 is the core body temperature of the patient.
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58. A device, comprising:
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an insertion device; and a controller adapted to control at least one of (a) an infusion rate of the infusate through the insertion device and (b) a volume of infusate passing through the insertion device, in accordance with a hematocrit of a blood and infusate mixture downstream of an exit location of the insertion of device, wherein hematocrit is calculated using a base whole body hematocrit of the patient (Hct) and dilution of the blood (dF). - View Dependent Claims (59, 60, 61, 62, 63, 64, 65, 66, 67)
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Specification