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Bispecific EGFR/IGFIR binding molecules

  • US 8,343,501 B2
  • Filed: 11/24/2009
  • Issued: 01/01/2013
  • Est. Priority Date: 11/24/2008
  • Status: Active Grant
First Claim
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1. An antibody-like protein dimer comprising (a) a tenth fibronectin type III domain (10Fn3) that binds insulin-like growth factor 1 receptor (IGF-IR) with a KD of less than 500 nM covalently or non-covalently linked to (b) a 10Fn3 that binds epidermal growth factor receptor (EGFR) with a KD of less than 500 nM;

  • wherein the IGF-IR binding 10Fn3 comprises a BC loop having the amino acid sequence set forth in amino acids 21-30 of SEQ ID NO;

    3, a DE loop having the amino acid sequence set forth in amino acids 51-56 of SEQ ID NO;

    3, and an FG loop having the amino acid sequence set forth in amino acids 76-83 of SEQ ID NO;

    3, andwherein the EGFR binding 10Fn3 comprises a BC loop having the amino acid sequence set forth in amino acids 21-30 of SEQ ID NO;

    112, a DE loop having the amino acid sequence set forth in amino acids 51-56 of SEQ ID NO;

    112, and an FG loop having the amino acid sequence set forth in amino acids 76-92 of SEQ ID NO;

    112.

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