Implantable drug delivery devices having alternating hydrophilic and amphiphillic polymer layers

• US 8,343,529 B2
• Filed: 05/17/2012
• Issued: 01/01/2013
• Est. Priority Date: 05/30/2008
• Status: Expired due to Fees

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Inventors: Hossainy, Syed F. A., Trollsas, Mikael O., Kleiner, Lothar W.
• Primary Examiner(s): Wax, Robert A
• Assistant Examiner(s): AL-AWADI, DANAH J
• Application Number:
  US13/474,448
• Publication Number:
  US 20120225303A1
• Time in Patent Office: 229 Days
• Field of Search: None
• US Class Current: 424/423
• CPC Class Codes: A61L 2420/08 Coatings comprising two or more layers
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: Y10T 428/31551 Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
• CPC Class Codes: Y10T 428/31562 Next to polyamide [nylon, etc.]
• CPC Class Codes: Y10T 428/31591 Next to cellulosic
• CPC Class Codes: Y10T 428/31736 Next to polyester
• CPC Class Codes: Y10T 428/3175 Next to addition polymer from unsaturated monomer[s]
• CPC Class Codes: Y10T 428/31786 Of polyester [e.g., alkyd, etc.]
• CPC Class Codes: Y10T 428/3179 Next to cellulosic
• CPC Class Codes: Y10T 428/31855 Of addition polymer from unsaturated monomers
• CPC Class Codes: Y10T 428/31891 Where addition polymer is an ester or halide

Abstract

An implantable drug delivery medical device with alternating hydrophilic and amphiphilic polymer layers and methods of using for the treatment of vascular disease are disclosed.

Claims

1. A soluble implantable medical device comprising alternating layers of hydrophilic and amphiphilic polymers;

wherein the amphiphilic polymer is selected from the group consisting of poly(n-butyl methacrylate-phosphorylcholine), poly(ester amide)-phosphorylcholine, polylactide-phosphorylcholine, polyethylene glycol-poly(caprolactone)-di- or tri-blocks, polyethylene glycol-polylactide di- or tri-blocks and polyethylene glycol-poly(lactide-glycolide) di- or tri-blocks.

2. The implantable medical device according to claim 1, wherein the hydrophilic polymer is selected from the group consisting of polyvinylpyrrolidone, poly(carboxymethyl cellulose) and poly[N-(2-hydroxypropyl)methacrylamide].

3. The implantable medical device according to claim 1, further comprising one or more bioactive agents integrated into the structure of or adhered to the surface of the device.

4. The implantable medical device according to claim 3, wherein the one or more bioactive agents are selected from the group consisting of an antiproliferative agent, an anti-inflammatory agent, an antineoplastic, an antimitotic, an antiplatelet, an anticoagulant, an antifibrin, an antithrombin, a cytostatic agent, an antibiotic, an anti-allergic agent, an anti-enzymatic agent, an angiogenic agent, a cyto-protective agent, a cardioprotective agent, a proliferative agent, an ABC A1 agonist, an antioxidant, and combinations thereof.

5. The implantable medical device according to claim 1, wherein the implantable medical device is a stent.

6. The implantable medical device according to claim 1, wherein the amphiphilic polymer is poly(n-butyl methacrylate-phosphorylcholine).

7. The implantable medical device according to claim 1, wherein the amphiphilic polymer is poly(ester amide)-phosphorylcholine.

8. The implantable medical device according to claim 1, wherein the amphiphilic polymer is polylactide-phosphorylcholine.

9. The implantable medical device according to claim 1, wherein the amphiphilic polymer is selected from the group consisting of polyethylene glycol-poly(caprolactone)-di- or tri-blocks.

10. The implantable medical device according to claim 1, wherein the amphiphilic polymer is selected from the group consisting of polyethylene glycol-polylactide di- or tri- blocks.

11. The implantable medical device according to claim 1, wherein the amphiphilic polymer is selected from the group consisting of polyethylene glycol-poly(lactide-glycolide) di- or tri-blocks.