Determining a neuromodulation treatment regimen in response to contactlessly acquired information

• US 8,346,354 B2
• Filed: 07/28/2009
• Issued: 01/01/2013
• Est. Priority Date: 07/28/2009
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Hyde, Roderick A., Ishikawa, Muriel Y., Leuthardt, Eric C., Rivet, Dennis J., Sweeney, Elizabeth A., Wood, Lowell L. Jr., Wood, Victoria Y. H.
• Primary Examiner(s): Manuel, George
• Assistant Examiner(s): Wieland, Robert N
• Application Number:
  US12/462,123
• Publication Number:
  US 20110029038A1
• Time in Patent Office: 1,253 Days
• Field of Search: 600/508, 600/509, 604/95.04, 607/907, 607/2, 607/4, 607/27, 607/32, 607/45, 607/59, 607/9, 606/27
• US Class Current: 607/2
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/4052 efferent nerves, i.e. nerves that relay impulses from the central nervous system
• CPC Class Codes: A61B 5/6846 specially adapted to be brought in contact with an internal body part, i.e. invasive
• CPC Class Codes: A61N 1/3601 of respiratory organs
• CPC Class Codes: A61N 1/36031 using physiological parameters for adjustment
• CPC Class Codes: A61N 1/36078 Inducing or controlling sleep or relaxation non-implantable stimulator A61M21/00
• CPC Class Codes: A61N 1/3611 Respiration control stimulating respiratory organs A61N1/3601
• CPC Class Codes: A61N 1/36139 with automatic adjustment
• CPC Class Codes: A61N 1/37211 Means for communicating with stimulators

Abstract

Described embodiments include a system, an apparatus, and a method. A described system includes a sensor device configured to sense a property of a mammal without physically contacting the mammal. The system also includes a signal generator configured to generate a signal indicative of the sensed property of the mammal. The system further includes a treatment decision device configured to determine in response to the signal indicative of the sensed property of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal. The system also includes a computer-readable medium configured to maintain and to provide access to information corresponding to the determined neuromodulation treatment regimen.

Claims

1. A system comprising:

a sensor device configured to sense a property of a mammal without physically touching the mammal;

a signal generator configured to generate a signal indicative of the sensed property of the mammal;

a patient confirmation device configured to confirm that the signal indicative of the sensed property of the mammal was originated in response to the mammal;

a feature interpretation device configured to generate data indicative of a physiological characteristic of the mammal in response to the signal indicative of the property of the mammal;

a treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal;

wherein the patient confirmation device is further configured to authorize administration of the neuromodulation treatment regimen to the mammal in response to confirmation that the signal indicative of the sensed property of the mammal was originated in response to the mammal; and

a patient records device configured to store information corresponding to the determined neuromodulation treatment regimen in a computer-readable medium and to provide electronic access to the stored information.

2. The system of claim 1, wherein the patient confirmation device comprises a RFID tag associated with the mammal.

3. The system of claim 1, wherein the signal generator configured to generate a signal indicative of the sensed property of the mammal includes:

a signal generator configured to generate and wirelessly transmit a signal indicative of the sensed property of the mammal.

4. The system of claim 1, wherein the feature interpretation device configured to generate data indicative of a physiological characteristic of the mammal in response to the signal indicative of the property of the mammal includes:

a feature interpretation device configured to generate data indicative of a brain waveform, cardiac waveform, neural activity, pupil diameter, breathing, temperature, movement, acoustic, or body position characteristic of the mammal in response to the signal indicative of the property of the mammal.

5. The system of claim 1, wherein the feature interpretation device configured to generate data indicative of a physiological characteristic of the mammal in response to the signal indicative of the property of the mammal includes:

a feature interpretation device configured to generate data indicative of a static or a varying physiological characteristic of the mammal in response to the signal indicative of the property of the mammal.

6. The system of claim 1, wherein the feature interpretation device configured to generate data indicative of a physiological characteristic of the mammal in response to the signal indicative of the property of the mammal includes:

a feature interpretation device not physically coupled with the sensor device and configured to generate data indicative of a physiological characteristic of the mammal in response to the signal indicative of the property of the mammal.

7. The system of claim 1, wherein the feature interpretation device configured to generate data indicative of a physiological characteristic of the mammal in response to the signal indicative of the property of the mammal includes:

a feature interpretation device physically coupled with the sensor device and configured to generate data indicative of a physiological characteristic of the mammal in response to the signal indicative of the property of the mammal.

8. The system of claim 1, wherein the feature interpretation device configured to generate data indicative of a physiological characteristic of the mammal in response to the signal indicative of the property of the mammal includes:

a feature interpretation device configured to receive a transmitted signal indicative of the property of the mammal, and to generate data indicative of a physiological characteristic of the mammal in response to the received signal indicative of the property of the mammal.

9. The system of claim 1, wherein the feature interpretation device configured to generate data indicative of a physiological characteristic of the mammal in response to the signal indicative of the property of the mammal includes:

a feature interpretation device configured to receive a wirelessly transmitted signal indicative of the property of the mammal, and to generate data indicative of a physiological characteristic of the mammal in response to the received signal indicative of the property of the mammal.

10. The system of claim 1, wherein the feature interpretation device configured to generate data indicative of a physiological characteristic of the mammal in response to the signal indicative of the property of the mammal includes:

a feature interpretation device configured to generate and to transmit via an electrically conductive pathway data indicative of a physiological characteristic of the mammal in response to the signal indicative of the property of the mammal.

11. The system of claim 1, wherein the feature interpretation device configured to generate data indicative of a physiological characteristic of the mammal in response to the signal indicative of the property of the mammal includes:

a feature interpretation device configured to generate and to wirelessly transmit data indicative of a physiological characteristic of the mammal in response to the signal indicative of the property of the mammal.

12. The system of claim 1, wherein the treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal includes:

a treatment decision device configured to decide if treatment is indicated in response to the data indicative of a physiological characteristic of the mammal, and to determine a neuromodulation treatment regimen for administration to a nervous system component of the mammal in response to the data indicative of a physiological characteristic of the mammal.

13. The system of claim 1, wherein the treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal includes:

a treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a selected outcome-promoting neuromodulation treatment regimen for administration to a nervous system component of the mammal.

14. The system of claim 1, wherein the treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal includes:

a treatment decision device configured to determine a neuromodulation treatment regimen for administration to a nervous system component of the mammal at least partially based upon the signal indicative of the sensed property of the mammal and a reference database of neuromodulation treatment regimens.

15. The system of claim 1, wherein the treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal includes:

a treatment decision device utilizing an algorithm configured to determine a neuromodulation treatment regimen for administration to a nervous system component of the mammal at least partially based upon the signal indicative of the sensed property of the mammal and a reference database of neuromodulation treatment regimens.

16. The system of claim 1, wherein the treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal includes:

a treatment decision device configured to determine a neuromodulation treatment regimen for an administration to a nervous system component of the mammal according to a selected outcome and in response to the data indicative of a physiological characteristic of the mammal.

17. The system of claim 1, wherein the treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal includes:

a treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal, the determined neuromodulation treatment regimen responsive to an electronically stored database relating a physiological characteristic of the mammal and a neuromodulation treatment regimen, a computer-implemented decision table, a digitally maintained neuromodulation treatment regimen table, or a digital library correlating physiological characteristics of the mammal and neuromodulation treatment regimens.

18. The system of claim 1, wherein the treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal includes:

a treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal, the determined neuromodulation treatment regimen including at least one of a source, frequency, waveform, duration, or amplitude characteristic.

19. The system of claim 1, wherein the treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal includes:

a treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal, the determined neuromodulation treatment regimen having at least one of a single instance of a neural stimulus, at least two instances of neural stimuli, or a course of neural stimuli.

20. The system of claim 1, wherein the treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal includes:

a treatment decision device not physically coupled with the feature interpretation device and configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal.

21. The system of claim 1, wherein the treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal includes:

a treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal, and configured to facilitate an administration of the neuromodulation treatment regimen to the nervous system component of the mammal.

22. The system of claim 1, wherein the treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neural stimulus for administration to a nervous system component of the mammal includes:

a treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal, and configured to control an administration of the selected neuromodulation treatment regimen to the nervous system component of the mammal by a neuromodulation device.

23. The system of claim 1, wherein the treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal includes:

a treatment decision device configured to determine a neuromodulation treatment regimen for administration to a nervous system component of the mammal in response to the data indicative of a physiological characteristic of the mammal and in response to a previous administration of at least one neuromodulation treatment regimen to the mammal.

24. The system of claim 1, wherein the treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal includes:

a treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a first neuromodulation treatment regimen and a second neuromodulation treatment regimen for a possible administration to a nervous system component of the mammal.

25. The system of claim 1, wherein the treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal includes:

a treatment decision device configured to determine a neuromodulation treatment regimen for administration to a nervous system component of the mammal in response to the data indicative of a physiological characteristic of the mammal and in response to data from another source.

26. The system of claim 1, wherein the treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal includes:

a treatment decision device configured to receive a transmitted signal indicative of the data indicative of a physiological characteristic of the mammal, and to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal.

27. The system of claim 1, wherein the treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal includes:

a treatment decision device configured to receive a wirelessly transmitted signal indicative of the data indicative of a physiological characteristic of the mammal, and to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal.

28. The system of claim 1, wherein the treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal includes:

a treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal, and to transmit information indicative of the selected neuromodulation treatment regimen via an electrically conductive pathway.

29. The system of claim 1, wherein the treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal includes:

a treatment decision device configured to determine in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal, and to wirelessly transmit information indicative of the selected neuromodulation treatment regimen.

30. The system of claim 1, further comprising:

a neuromodulation device configured to administer the selected neuromodulation treatment regimen to the nervous system component of the mammal.

31. The system of claim 30, wherein the neuromodulation device configured to administer the selected neuromodulation treatment regimen to the nervous system component of the mammal includes:

a neuromodulation device physically associable with the mammal and configured to administer the selected neuromodulation treatment regimen to the nervous system component of the mammal.

32. The system of claim 30, wherein the neuromodulation device configured to administer the selected neuromodulation treatment regimen to the nervous system component of the mammal includes:

a neuromodulation device operable to generate and administer the selected neuromodulation treatment regimen to a nervous system component of the mammal.

33. The system of claim 30, wherein the neuromodulation device configured to administer the selected neuromodulation treatment regimen to the nervous system component of the mammal includes:

a neuromodulation device operable to administer the selected neuromodulation treatment regimen to a nervous system component of the mammal while the mammal is within a space.

34. The system of claim 30, wherein the neuromodulation device configured to administer the selected neuromodulation treatment regimen to the nervous system component of the mammal includes:

a neuromodulation device operable to automatically administer the selected neuromodulation treatment regimen to a nervous system component of the mammal in response to at least one of a command received from the treatment decision device, in response to an input initiated by the mammal, or in response to an input initiated by a health care provider.

35. The system of claim 30, wherein the neuromodulation device configured to administer the selected neuromodulation treatment regimen to the nervous system component of the mammal includes:

a neuromodulation device configured to administer the selected neuromodulation treatment regimen to a component of the vagal nervous system of the mammal.

36. The system of claim 30, wherein the neuromodulation device configured to administer the selected neuromodulation treatment regimen to the nervous system component of the mammal includes:

a neuromodulation device configured to administer the selected neuromodulation treatment regimen to a central nervous system component of the mammal.

37. The system of claim 30, wherein the neuromodulation device configured to administer the selected neuromodulation treatment regimen to the nervous system component of the mammal includes:

a neuromodulation device configured to administer the selected neuromodulation treatment regimen to a component of the brain of the mammal.

38. The system of claim 30, wherein the neuromodulation device configured to administer the selected neuromodulation treatment regimen to the nervous system component of the mammal includes:

a neuromodulation device configured to administer the selected neuromodulation treatment regimen to a component of the spinal cord of the mammal.

39. The system of claim 30, wherein the neuromodulation device configured to administer the selected neuromodulation treatment regimen to the nervous system component of the mammal includes:

a neuromodulation device configured to administer the selected neuromodulation treatment regimen to a component of the peripheral nervous system of the mammal.

40. The system of claim 30, wherein the neuromodulation device configured to administer the selected neuromodulation treatment regimen to the nervous system component of the mammal includes:

a neuromodulation device configured to administer the selected neuromodulation treatment regimen to a component of the somatic nervous system of the mammal.

41. The system of claim 30, wherein the neuromodulation device configured to administer the selected neuromodulation treatment regimen to the nervous system component of the mammal includes:

a neuromodulation device configured to administer the selected neuromodulation treatment regimen to a sensory nerve, a motor nerve, an autonomic nervous system component, or an enteric nervous system component of the mammal.

42. The system of claim 30, wherein the neuromodulation device configured to administer the selected neuromodulation treatment regimen to the nervous system component of the mammal includes:

a neuromodulation device configured to administer the selected neuromodulation treatment regimen to a neurotransmitter-releasing component of the nervous system of the mammal.

43. The system of claim 30, wherein the neuromodulation device configured to administer the selected neuromodulation treatment regimen to the nervous system component of the mammal includes:

a neuromodulation device configured to receive a transmitted signal indicative of the selected neuromodulation treatment regimen via an electrically conductive pathway, and to administer the selected neuromodulation treatment regimen to the nervous system component of the mammal.

44. The system of claim 30, wherein the neuromodulation device configured to administer the selected neuromodulation treatment regimen to the nervous system component of the mammal includes:

a neuromodulation device configured to receive a wirelessly transmitted signal indicative of the selected neuromodulation treatment regimen, and to administer the selected neuromodulation treatment regimen to the nervous system component of the mammal.

45. The system of claim 1, further comprising:

an illumination source operable to illuminate at least a portion of the mammal with an energy to which the sensor device is responsive.

46. The system of claim 45, wherein the illumination source operable to illuminate at least a portion of the mammal with an energy to which the sensor device is responsive includes:

an illumination source operable to illuminate at least a portion of the mammal with an energy to which the sensor device is responsive, and configured for a physical association with an object.

47. A method comprising:

sensing a property of a mammal without physically touching the mammal;

confirming that the mammal is the source of the sensed property;

generating a signal indicative of the sensed property of the mammal;

generating data indicative of a physiological characteristic of the mammal in response to the signal indicative of the property of the mammal;

determining in response to the data indicative of a physiological characteristic of the mammal a neuromodulation treatment regimen for administration to a central nervous system component of the mammal;

authorizing administration of the neuromodulation treatment regimen in response to confirming that the mammal is the source of the sensed property;

storing information corresponding to the determined neuromodulation treatment regimen in a computer-readable medium; and

providing electronic access to the stored information.

48. A system comprising:

a sensor device including a pupillometer operable to generate a sensor signal indicative of a property of the mammal, wherein the sensor device is incorporated into a computer monitor or a dashboard of a vehicle;

a feature interpretation device operable to generate data indicative of a physiological characteristic of the mammal in response to the sensor signal indicative of a property of the mammal;

a patient diagnostic device operable to identify a disease, disorder, or medically treatable condition in response to the data indicative of a physiological characteristic of the mammal;

a treatment decision device operable to determine a neuromodulation treatment regimen responsive to the identified disease, disorder, or medically treatable condition; and

a patient records device configured to store information corresponding to the determined neuromodulation treatment regimen in a computer-readable medium and to provide electronic access to the stored information.

49. The system of claim 48, further comprising:

a neuromodulation device operable to administer the chosen neuromodulation treatment regimen to a nervous system component of the mammal.