Hierarchical sample storage system

• US 8,346,382 B2
• Filed: 08/14/2006
• Issued: 01/01/2013
• Est. Priority Date: 08/25/2005
• Status: Active Grant

• Current Assignee: BioTillion, LLC
• Original Assignee: Coldtrack LLC
• Inventors: Davidowitz, Hananel, Coradetti, Thomas, Talmi, Yair
• Primary Examiner(s): LEVKOVICH, NATALIA A
• Application Number:
  US12/064,748
• Publication Number:
  US 20090026907A1
• Time in Patent Office: 2,332 Days
• Field of Search: 700/214, 700/215, 700/225, 700/236, 700/242, 700/241, 422/105
• US Class Current: 700/125
• CPC Class Codes: B01L 1/50 for storing hazardous materials in the laboratory, e.g. cupboards, waste containers sample containers B01L3/50
• CPC Class Codes: G01N 2035/00445 Other cooling arrangements
• CPC Class Codes: G01N 2035/00782 reprogrammmable code
• CPC Class Codes: G01N 35/00722 Communications; Identification
• CPC Class Codes: G01N 35/00871 Communications between instruments or with remote terminals

Abstract

In one embodiment, a cold storage system for biological samples has one or more freezers, each freezer having one or racks, each rack receiving one or more boxes, each box receiving one or more sample containers. In addition to the biological sample, each sample container has a unique passive RFID tag. Control electronics in each box energize reader coils to query individual RFID tags. Control electronics in each rack communicate with and provide power to the control electronics of each corresponding box, and control electronics in each freezer communicate with and provide power to the control electronics of each corresponding rack, and a host computer communicates with the control electronics in each freezer. In each instance, communication and power provisioning is implemented using magnetic inductive coupling. The system is able to determine the identity of each sample container in the system and maintain that information in a database.

Claims

1. A system for storing samples, the system comprising at least one first cabinet, at least one first box, and one or more sample containers, wherein:

the first cabinet comprises first cabinet control electronics and is configured to receive the first box;

the first box comprises first box control electronics and is configured to receive the one or more sample containers, each sample container comprising container electronics and configured to store a sample;

the first box control electronics is configured to communicate with the container electronics of each sample container received by the first box;

the container electronics of each sample container is configured to communicate sample-identification information for the sample stored in the sample container to the first box control electronics;

the first box control electronics is configured to communicate the sample-identification information towards the first cabinet control electronics;

the first cabinet control electronics is configured to communicate the sample-identification information to a host computer for the system;

each container electronics is an RFID tag having an associated tag coil;

the first box has at least one reader coil associated with each sample container received by the first box; and

the first box has a plurality of slots, each slot having an associated reader coil, such that, if a sample container is inserted within a slot, the associated reader coil is configured to energize the tag coil of the corresponding slot to activate the associated RFID tag.

2. The system of claim 1, wherein the system further comprises one or more other instances of the first cabinet.

3. The system of claim 1, wherein the system further comprises one or more other instances of the first box configured to be received by the first cabinet.

4. The system of claim 1, wherein:

the system further comprises at least one first rack;

the first rack comprises first rack control electronics and is configured to receive the first box;

the first rack control electronics is configured to communicate with the first box control electronics;

the first box control electronics is configured to communicate the sample-identification information to the first rack control electronics; and

the first rack control electronics is configured to communicate the sample-identification information towards the first cabinet control electronics.

5. The system of claim 4, wherein the system further comprises:

one or more other instances of the first rack configured to be received by the first cabinet; and

one or more other instances of the first box configured to be received by the plurality of instances of the first rack.

6. The system of claim 4, wherein:

the system further comprises at least one first shelf;

the first shelf comprises first shelf control electronics and is configured to receive the first rack;

the first shelf control electronics is configured to communicate with the first rack control electronics;

the first rack control electronics is configured to communicate the sample-identification information to the first shelf control electronics; and

the first shelf control electronics is configured to communicate the sample-identification information towards the first cabinet control electronics.

7. The system of claim 6, wherein the system further comprises:

one or more other instances of the first shelf configured to be received by the first cabinet; and

one or more other instances of the first rack configured to be received by the plurality of instances of the first shelf; and

one or more other instances of the first box configured to be received by the plurality of instances of the first rack.

8. The system of claim 1, wherein:

the system is a cold storage system; and

the first cabinet is a first freezer having first freezer control electronics, wherein the first freezer control electronics are the first cabinet control electronics.

9. The system of claim 8, wherein:

the first freezer comprises a first-temperature side having a first temperature; and

each container electronics and the first box control electronics are housed within the first-temperature side of the first freezer.

10. The system of claim 9, wherein:

the communications between the container electronics of each sample container and the first box control electronics are implemented using non-ohmic coupling; and

the communications between the box control electronics and the first freezer control electronics are implemented using non-ohmic coupling.

11. The system of claim 10, wherein:

the non-ohmic coupling between the first freezer control electronics and the first box control electronics transfers operating power from the first freezer control electronics to the first box control electronics; and

the non-ohmic coupling between the first box control electronics and the container electronics of each sample container transfers operating power from the box control electronics to the container electronics.

12. The system of claim 9, wherein:

the first freezer further comprises a second-temperature side having a second temperature greater than the first temperature; and

the first freezer control electronics is housed within the second-temperature side of the first freezer.

13. The system of claim 1, wherein the first box control electronics is implemented on a printed circuit board within which is integrated each corresponding reader coil.

14. The system of claim 1, wherein:

the first cabinet control electronics are configured to communicate with the first box control electronics via corresponding non-ohmic coupling; and

the first box control electronics are configured to communicate with the container electronics of each corresponding sample container via corresponding non-ohmic coupling.

15. The system of claim 14, wherein each instance of non-ohmic coupling is inductive magnetic coupling.

16. The system of claim 14, wherein:

the first cabinet control electronics are configured to transfer operating power to the first box control electronics box via the corresponding non-ohmic coupling; and

the first box control electronics are configured to transfer operating power to the container electronics of each corresponding sample container via the corresponding non-ohmic coupling.

17. The system of claim 1, wherein:

the system further comprises at least one first sample container; and

the first sample container comprises (i) an untagged tube containing the sample and (ii) a tagged tube containing the container electronics, wherein the untagged tube is inserted within the tagged tube.

18. The system of claim 17, wherein the tagged tube comprises a mechanism that engages structure of the untagged tube to retain the untagged tube within the tagged tube.

19. The system of claim 18, wherein the mechanism comprises an insert that cuts into structural material of the untagged tube to retain the untagged tube within the tagged tube.

20. The system of claim 18, wherein the untagged tube comprises a ridge that engages with the mechanism to retain the untagged tube within the tagged tube.

21. The system of claim 18, wherein the untagged tube is configured to be released from the tagged tube by inserting a releasing tool between the structure of the untagged tube and the mechanism of the tagged tube.

22. The system of claim 1, wherein the system further comprises the host computer.

23. The system of claim 22, wherein the host computer is configured to control operations of the system to autonomously identify each sample stored within the system.

24. The system of claim 23, wherein the host computer is configured to autonomously identify each sample stored within the system by causing each container electronics to be individually queried to provide its corresponding sample-identification information.

25. The system of claim 1, wherein the sample-identification information uniquely identifies each sample.

26. The system of claim 4, wherein:

the system is a cold storage system;

the first cabinet is a first freezer having first freezer control electronics, wherein the first freezer control electronics are the first cabinet control electronics;

the first freezer comprises a first-temperature side having a first-temperature;

each container electronics and the first box control electronics are housed within the first-temperature side of the first freezer;

the communications between the container electronics of each sample container and the first box control electronics are implemented using non-ohmic coupling;

the communications between the box control electronics and the first freezer control electronics are implemented using non-ohmic coupling;

the non-ohmic coupling between the first freezer control electronics and the first box control electronics transfers operating power from the first freezer control electronics to the first box control electronics;

the non-ohmic coupling between the first box control electronics and the container electronics of each sample container transfers operating power from the box control electronics to the container electronics;

the first freezer further comprises a second-temperature side having a second temperature greater than the first temperature;

the first freezer control electronics is housed within the second-temperature side of the first freezer;

the first box control electronics is implemented on a printed circuit board within which is integrated each corresponding reader coil;

the system further comprises at least one first sample container;

the first sample container comprises (i) an untagged tube containing the sample and (ii) a tagged tube containing the container electronics, wherein the untagged tube is inserted within the tagged tube;

the tagged tube comprises a mechanism that engages structure of the untagged tube to retain the untagged tube within the tagged tube;

one of (1) the mechanism comprises an insert that cuts into structural material of the untagged tube to retain the untagged tube within the tagged tube and (2) the untagged tube comprises a ridge that engages with the mechanism to retain the untagged tube within the tagged tube; and

the untagged tube is configured to be released from the tagged tube by inserting a releasing tool between the structure of the untagged tube and the mechanism of the tagged tube.

27. A system for storing samples, the system comprising at least one first cabinet, at least one first box, and one or more sample containers, wherein:

the first cabinet comprises first cabinet control electronics and is configured to receive the first box;

the first box comprises first box control electronics and is configured to receive the one or more sample containers, each sample container comprising container electronics and configured to store a sample;

the first box control electronics is configured to communicate with the container electronics of each sample container received by the first box;

the container electronics of each sample container is configured to communicate sample-identification information for the sample stored in the sample container to the first box control electronics;

the first box control electronics is configured to communicate the sample-identification information towards the first cabinet control electronics;

the first cabinet control electronics is configured to communicate the sample-identification information to a host computer for the system;

the system further comprises at least one first sample container; and

the first sample container comprises (i) an untagged tube configured to contain the sample and (ii) a tagged tube containing the container electronics, wherein the untagged tube is inserted within the tagged tube.

28. The system of claim 27, wherein the tagged tube comprises a mechanism that engages structure of the untagged tube to retain the untagged tube within the tagged tube.

29. The system of claim 28, wherein the mechanism comprises an insert that cuts into structural material of the untagged tube to retain the untagged tube within the tagged tube.

30. The system of claim 28, wherein the untagged tube comprises a ridge that engages with the mechanism to retain the untagged tube within the tagged tube.

31. The system of claim 28, wherein the untagged tube is configured to be released from the tagged tube by inserting a releasing tool between the structure of the untagged tube and the mechanism of the tagged tube.