Device and method for computer simulated marking targeting biopsy

• US 8,348,831 B2
• Filed: 12/15/2009
• Issued: 01/08/2013
• Est. Priority Date: 12/15/2009
• Status: Active Grant

• Current Assignee: Hangzhou Botong Gastroenteropathy Treatment Technology Co., Ltd., Zhejiang University
• Original Assignee: Hangzhou Botong Gastroenteropathy Treatment Technology Co., Ltd., Zhejiang University
• Inventors: Wang, Liangjing, Si, Jianmin, Liu, Jiquan, Feng, Jingyi, Chen, Shujie, Wu, Jiaguo, Lv, Yi
• Primary Examiner(s): Laballe, Clayton E
• Assistant Examiner(s): BUTLER, KEVIN C
• Application Number:
  US12/638,955
• Publication Number:
  US 20110144432A1
• Time in Patent Office: 1,120 Days
• Field of Search: 600101-117, 600/424, 738/665
• US Class Current: 600/117
• CPC Class Codes: A61B 1/2736 Gastroscopes
• CPC Class Codes: A61B 5/06 Devices, other than using radiation, for detecting or locating foreign bodies for removing same A61B17/50 ; determining position of probes within or on the body of the patient
• CPC Class Codes: A61B 5/065 Determining position of the probe employing exclusively positioning means located on or in the probe, e.g. using position sensors arranged on the probe
• CPC Class Codes: A61B 6/03 Computed tomography [CT] echo-tomography A61B8/14

Abstract

A device for Computer Simulated Marking Targeting Biopsy (CSMTB) has at least a space locator, and a main control module, including a surface model sub-module, a positioning sub-module, a tracking sub-module, a virtual endoscope sub-module, and a marking targeting biopsy sub-module. The device accurately detects minimal gastric lesions, and reduces pain to patients and thus decreases the workload of a doctor.

Claims

1. A device for Computer Simulated Marking Targeting Biopsy, comprising

a space locator;

and

a main control module, comprising

a surface model sub-module;

a positioning sub-module;

a tracking sub-module;

a virtual endoscope sub-module; and

a marking targeting biopsy sub-module;

wherein

said space locator is connected to said main control module, and operates to obtain position and orientation information of a probe of a gastroscope;

said surface model sub-module operates to construct and store a 3D surface model of inner wall of a stomach;

said positioning sub-module operates to collect and store a signal from said space locator;

said tracking sub-module operates to read data in said positioning sub-module and to adjust a position and an orientation of a virtual endoscopic viewpoint in said 3D surface model of the inner wall of the stomach;

said virtual endoscope sub-module operates to endoscopically image and display said 3D surface model of the inner wall of the stomach according to the position and the orientation of said virtual endoscopic viewpoint; and

said marking targeting biopsy sub-module operates to record the position and the orientation of said virtual endoscopic viewpoint, to mark the position and the orientation of said virtual endoscopic viewpoint in said 3D surface model of inner wall of a stomach, to navigate the probe to a position and an orientation in the stomach cavity according to a pre-recorded position and orientation of said virtual endoscopic viewpoint, and to display an endoscopic image of the stomach obtained by the probe during endoscopic imaging of said 3D surface model of the inner wall of the stomach.

2. The device for Computer Simulated Marking Targeting Biopsy of claim 1, wherein said space locator comprises a magnetic field transmitter, an electronics unit, a signal preamplifier, and a sensor.

3. The device for Computer Simulated Marking Targeting Biopsy of claim 2, wherein said electronics unit is connected to said magnetic field transmitter via a parallel interface, and to an output end of said signal preamplifier via a signal line.

4. The device for Computer Simulated Marking Targeting Biopsy of claim 2, wherein said sensor is connected to an input end of said signal preamplifier, and operates to obtain position and orientation information of the probe of the gastroscope.

5. The device for Computer Simulated Marking Targeting Biopsy of claim 2, wherein said electronics unit is connected to said main control module.

7. The device of claim 1, wherein said marking targeting biopsy sub-module comprises a data storage unit, said data storage unit is adapted to record position and orientation data of virtual endoscopic viewpoints, and said marking targeting biopsy sub-module is adapted to write the data to and read the data from said data storage unit.

8. The device of claim 7, wherein:

when said marking targeting biopsy sub-module is operated to mark a position and an orientation of a virtual endoscopic viewpoint, said marking targeting biopsy sub-module writes the position and orientation data to said data storage unit, and said data storage unit records the position and orientation data;

when said marking targeting biopsy sub-module is operated to navigate the probe, said marking targeting biopsy sub-module reads the position and orientation data from said data storage unit and provides a guidance for the probe to a position and an orientation in the stomach cavity according to the position and orientation data.

6. A method for Computer Simulated Marking Targeting Biopsy, comprising;

(a) obtaining a slice-scan image sequence of a stomach cavity of a patient by a computed tomography equipment;

(b) analyzing and performing threshold segmentation on said slice-scan image sequence whereby obtaining a binary image that distinguishes a cavity region of a stomach of the patient from a non-cavity region thereof;

(c) extracting an interface between said cavity region and said non-cavity region whereby constructing and rendering a 3D surface model of inner wall of the stomach;

(d) obtaining position and orientation information of a probe of a gastroscope via a space locator;

(e) adjusting a position and an orientation of a virtual endoscopic viewpoint in said 3D surface model of the inner wall of the stomach according to said position and orientation information of the probe of the gastroscope;

(f) endoscopically imaging and displaying said 3D surface model of the inner wall of the stomach according to the position and the orientation of said virtual endoscopic viewpoint;

(g) recording the position and the orientation of said virtual endoscopic viewpoint and marking the position and the orientation of said virtual endoscopic viewpoint in said 3D surface model of inner wall of a stomach resulting in a pre-recorded position and orientation of said virtual endoscopic viewpoint; and

(h) navigating the probe to a position and an orientation in the stomach cavity according to said pre-recorded position and orientation of said virtual endoscopic viewpoint, and displaying an endoscopic image of the stomach obtained by the probe during endoscopic imaging of said 3D surface model of the inner wall of the stomach.

9. The method of claim 6, wherein (a) through (g) take place during a first biopsy, and (h) takes place during a second biopsy.