Nested balloon catheter for localized drug delivery
First Claim
1. A balloon catheter for delivering a therapeutic and/or diagnostic agent to tissue, comprising:
- an outer balloon having a wall with at least one opening therethrough and an inner surface;
an inner balloon at least partially disposed in said outer balloon, said inner balloon at least partially enclosing an inflation chamber and having an outer surface defining a space between the outer surface of said inner balloon and the inner surface of said outer balloon;
a catheter havinga first lumen in fluid communication with the space between the outer surface of said inner balloon and the inner surface of said outer balloon for supplying a therapeutic and/or diagnostic agent thereto; and
a second lumen through which fluid is supplied to the inflation chamber of said inner balloon for inflating said inner balloon to urge the therapeutic and/or diagnostic agent out of the at least one opening in the wall of said outer balloon and into tissue;
wherein at least one of said outer balloon and said inner balloon comprise at least one protrusion for directing the therapeutic and/or diagnostic agent; and
wherein the outer surface of said inner balloon comprises a first protrusion and a second protrusion, the first and second protrusions extending longitudinally and forming a channel therebetween, wherein an outer surface of said outer balloon comprises a third protrusion having an annular shape, and wherein the at least one opening in the wall of said outer balloon is enclosed by the third annular protrusion.
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Accused Products
Abstract
A balloon catheter for delivering a therapeutic and/or diagnostic agent to tissue is described including an outer balloon having a wall with an opening therethrough and an inner surface, an inner balloon disposed in the outer balloon, enclosing an inflation chamber and having an outer surface defining a space between the outer surface of the inner balloon and the inner surface of the outer balloon, a catheter having a first lumen in fluid communication with the space between the inner balloon and the outer balloon for supplying the agent thereto, and a second lumen through which fluid is supplied to the inflation chamber for inflating the inner balloon to urge the agent out of the opening in the outer balloon, wherein the outer balloon and/or the inner balloon comprise at least one protrusion for directing the agent.
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Citations
54 Claims
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1. A balloon catheter for delivering a therapeutic and/or diagnostic agent to tissue, comprising:
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an outer balloon having a wall with at least one opening therethrough and an inner surface; an inner balloon at least partially disposed in said outer balloon, said inner balloon at least partially enclosing an inflation chamber and having an outer surface defining a space between the outer surface of said inner balloon and the inner surface of said outer balloon; a catheter having a first lumen in fluid communication with the space between the outer surface of said inner balloon and the inner surface of said outer balloon for supplying a therapeutic and/or diagnostic agent thereto; and a second lumen through which fluid is supplied to the inflation chamber of said inner balloon for inflating said inner balloon to urge the therapeutic and/or diagnostic agent out of the at least one opening in the wall of said outer balloon and into tissue; wherein at least one of said outer balloon and said inner balloon comprise at least one protrusion for directing the therapeutic and/or diagnostic agent; and wherein the outer surface of said inner balloon comprises a first protrusion and a second protrusion, the first and second protrusions extending longitudinally and forming a channel therebetween, wherein an outer surface of said outer balloon comprises a third protrusion having an annular shape, and wherein the at least one opening in the wall of said outer balloon is enclosed by the third annular protrusion.
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2. A balloon catheter for delivering a therapeutic and/or diagnostic agent to tissue, comprising:
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an outer balloon having a wall with at least one opening therethrough and an inner surface; an inner balloon at least partially disposed in said outer balloon, said inner balloon at least partially enclosing an inflation chamber and having an outer surface defining a space between the outer surface of said inner balloon and the inner surface of said outer balloon; a catheter having a first lumen in fluid communication with the space between the outer surface of said inner balloon and the inner surface of said outer balloon for supplying a therapeutic and/or diagnostic agent thereto; and a second lumen in fluid communication with the inflation chamber of said inner balloon for supplying fluid thereto to inflate said inner balloon; and a fluid source in fluid communication with said second lumen for inflating said inner balloon to urge the therapeutic and/or diagnostic agent out of the at least one opening in the wall of said outer balloon and into tissue; wherein said fluid source supplies fluid to said second lumen in pulsed fashion to repeatedly inflate and at least partially deflate said inner balloon. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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33. A method of localized delivery of a therapeutic and/or diagnostic agent to tissue, comprising the steps of:
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inserting a catheter into a bodily cavity, said catheter comprising an outer balloon having a wall with at least one opening therethrough and an inner surface; and an inner balloon at least partially disposed in said outer balloon, said inner balloon at least partially enclosing an inflation chamber and having an outer surface defining a space between the outer surface of said inner balloon and the inner surface of said outer balloon; supplying the therapeutic and/or diagnostic agent to the space between the outer surface of said inner balloon and the inner surface of said outer balloon via a first lumen of said catheter; inflating said inner balloon by supplying fluid to the inflation chamber via a second lumen of said catheter to urge the therapeutic and/or diagnostic agent out of the at least one opening in the wall of said outer balloon and into tissue; and repeatedly deflating and inflating said inner balloon by supplying fluid to the inflation chamber in pulsed fashion. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54)
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Specification