Gels with predetermined conductivity used in electroporation of tissue
First Claim
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1. A method of carrying out electroporation of tissue, comprising:
- inserting a gel in a form of colloidal dispersion into tissue in a patient wherein the gel conductivity is adjusted to be substantially the same as the conductivity of a surrounding tissue;
applying current across the tissue in an amount so that cells of the tissue are subjected to electroporation;
wherein when the current is applied to the tissue, a homogenous electrical field is applied and a specific area of targeted tissue is subjected to electroporation.
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Abstract
Gel compositions with adjusted conductivity are disclosed which compositions are used for directing reversible electroporation and irreversible electroporation of cells and tissue. The gel compositions are also used in a similar manner in order to carry out thermotherapy on cells and tissues.
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Citations
13 Claims
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1. A method of carrying out electroporation of tissue, comprising:
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inserting a gel in a form of colloidal dispersion into tissue in a patient wherein the gel conductivity is adjusted to be substantially the same as the conductivity of a surrounding tissue; applying current across the tissue in an amount so that cells of the tissue are subjected to electroporation; wherein when the current is applied to the tissue, a homogenous electrical field is applied and a specific area of targeted tissue is subjected to electroporation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of carrying out electroporation of tissue, comprising:
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inserting a gel in a form of colloidal dispersion into tissue in a patient wherein the gel conductivity is adjusted to be substantially the same as the conductivity of a surrounding tissue, and the gel acts as an electrode and is injectable and biodegradable; applying current across the tissue in an amount so that cells of the tissue are subjected to electroporation; wherein when the current is applied to the tissue, a homogenous electrical field is applied and a specific area of targeted tissue is subjected to electroporation.
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13. A method of carrying out electroporation of tissue, comprising:
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inserting a gel in a form of colloidal dispersion into tissue in a patient wherein the gel conductivity is adjusted to be substantially the same as the conductivity of a surrounding tissue, and the gel acts as an electrode and is injectable and biodegradable; applying current across the tissue in an amount so that cells of the tissue are subjected to irreversible electroporation; wherein when the current is applied to the tissue, a homogenous electrical field is applied and a specific area of targeted tissue is subjected to irreversible electroporation.
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Specification