Fluid delivery device with a diffusion membrane and electrochemical pump

• US 8,348,930 B2
• Filed: 03/11/2010
• Issued: 01/08/2013
• Est. Priority Date: 07/01/2005
• Status: Expired due to Fees

• Current Assignee: Microlin LLC
• Original Assignee: Microlin LLC
• Inventors: Gordon, John Howard, Joshi, Ashok V.
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): OSINSKI, BRADLEY JAMES
• Application Number:
  US12/721,636
• Publication Number:
  US 20100222770A1
• Time in Patent Office: 1,034 Days
• Field of Search: 6048901-8921, 604500-502
• US Class Current: 604/892.1
• CPC Class Codes: A61M 2005/14204 with gas-producing electrochemical cell
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/14276 specially adapted for implantation

Abstract

A fluid delivery device can be used to deliver fluid within a living body. The fluid delivery device includes an electrochemical pump, a reservoir, a displaceable member, and a diffuse membrane. The electrochemical pump transports water and includes an electrochemical pump product chamber to retain water transported by the electrochemical pump. The reservoir contains a fluid to be delivered. The displaceable member is positioned between the electrochemical pump product chamber and the reservoir. The displaceable member is responsive to the electrochemical pump transporting water into the electrochemical pump product chamber. The diffuse membrane generates increased pressure within the electrochemical pump product chamber.

Claims

1. A fluid delivery device, comprising:

an electrochemical pump for transporting water, the electrochemical pump comprising an electrochemical pump product chamber configured to retain water transported by the electrochemical pump, an active electrode, an auxiliary electrode configured for ionic communication with the active electrode, an ion-exchange membrane positioned between the active electrode and the auxiliary electrode, wherein the ion-exchange membrane is configured to transport water by osmosis and electro-osmosis between the active electrode and the auxiliary electrode into the electrochemical pump product chamber, wherein one of the electrodes is located in the first chamber portion of the electrochemical pump product chamber, and the other electrode is located on an opposite side of the ion-exchange membrane;

a reservoir configured to contain a fluid to be delivered;

a displaceable member positioned between the electrochemical pump product chamber and the reservoir, wherein the displaceable member is responsive to the electrochemical pump transporting water into the electrochemical pump product chamber; and

a diffuse membrane configured to generate increased pressure within the electrochemical pump product chamber, wherein the diffuse membrane is located within the electrochemical pump product chamber, wherein the diffuse membrane at least partially defines a first chamber portion and a second chamber portion within the electrochemical pump product chamber, and wherein the diffuse membrane comprises a substantially planar barrier with at least one hole therethrough having cross-sectional dimensions to prevent substantially all advection of water from the first chamber portion to the second chamber portion in the absence of electro-osmosis through the ion-exchange membrane.

2. The fluid delivery device of claim 1, wherein the electrochemical pump further comprises a controller coupled to the active electrode and the auxiliary electrode, wherein the controller is configured to generate an electrical current and facilitate water transport through the ion-exchange membrane in response to the electrical current.

3. The fluid delivery device of claim 2, wherein the construction of the fluid delivery device is suitable for implantation within a living body.

4. The fluid delivery device of claim 3, wherein the controller is configured to be capable of remote adjustment external to the living body.

5. The fluid delivery device of claim 2, wherein the controller is configured to be capable of varying a fluid delivery rate in response to varying a resistance of the controller.

6. The fluid delivery device of claim 1, further comprising a housing to contain the active electrode and the auxiliary electrode of the electrochemical pump, the electrochemical pump product chamber of the electrochemical pump, the diffuse membrane of the electrochemical pump, the displaceable member, and the reservoir.

7. The fluid delivery device according to claim 6, wherein, the auxiliary electrode is positioned within the housing.

8. The fluid delivery device of claim 6, further comprising a separator being permeable to H₂O molecules or saline, the separator being attached to the housing, wherein the separator is configured for direct contact with a body tissue or fluid when the fluid delivery device is inserted within a living body, and one or more of either electrode or the ion-exchange membrane is indirectly exposed and not in direct contact with the body tissue or fluid.

9. The fluid delivery device of claim 6, wherein the housing defines a plurality of apertures, wherein at least one aperture is located at the reservoir to allow the fluid to exit the reservoir.

10. The fluid delivery device of claim 9, further comprising at least one catheter operably connected to the aperture at the reservoir.

11. The fluid delivery device of claim 10, wherein the at least one catheter is flexible.

12. The fluid delivery device of claim 10, wherein the at least one catheter is perforated.

13. The fluid delivery device of claim 10, wherein the at least one catheter comprises a diffusive outlet.

14. The fluid delivery device of claim 10, wherein the at least one catheter comprises a check valve.

15. The fluid delivery device according to claim 6, further comprising a housing to contain the active electrode, the electrochemical pump product chamber of the electrochemical pump, the diffuse membrane of the electrochemical pump, the displaceable member, and the reservoir, wherein, the auxiliary electrode of the electrochemical pump is positioned external to the housing.

16. The fluid delivery device of claim 1, further comprising:

a galvanic couple comprising the auxiliary electrode and active electrode.

17. The fluid delivery device of claim 1, wherein the ion exchange membrane is an anionic or cationic type.

18. The fluid delivery device of claim 1, wherein the ion-exchange membrane is a polymer or ceramic material.

19. The fluid delivery device of claim 1, wherein the ion-exchange membrane includes a geometry being a sheet, a hollow fiber, or a tube.

20. The fluid delivery device of claim 1, further including a second or multiple ion-exchange membrane.

21. The fluid delivery device of claim 20, wherein the ion-exchange membranes are of similar type.

22. The fluid delivery device of claim 20, wherein the ion-exchange membranes are of different type.

23. The fluid delivery device of claim 1, further comprising:

an auxiliary electrode compartment being impermeable to body fluid, the auxiliary electrode compartment containing saline and the auxiliary electrode; and

a second displaceable member to define at least a portion of the auxiliary electrode compartment, wherein the second displaceable member is configured to retract in response to transfer of water from the auxiliary electrode compartment through the ion-conducting membrane to the electrochemical pump product chamber.

24. The fluid delivery device of claim 1, further comprising:

an auxiliary electrode compartment being impermeable to body fluid, the auxiliary electrode compartment containing saline and the auxiliary electrode, wherein the auxiliary electrode compartment is configured to collapse in response to transfer of water from the auxiliary electrode compartment through the ion-conducting membrane to the electrochemical pump product chamber.

25. The fluid delivery device according to claim 1, wherein the electrochemical pump further comprises an activation switch for operating the fluid delivery device.

26. The fluid delivery device of claim 25, wherein the activation switch is of an ionic, electronic, or mechanical type.

27. The fluid delivery device of claim 25, wherein the activation switch is controlled by the controller.

28. The fluid delivery device of claim 1, wherein the electrochemical pump further comprises a support member for supporting the ion-exchange membrane.

29. The fluid delivery device of claim 28, wherein the support member is a porous solid material selected from the group consisting of plastic, ceramic, glass, corrosion stable metal, and a combination thereof.

30. The fluid delivery device of claim 28, wherein the support member comprises a structure selected from the group consisting of fabric, perforated plate, and mesh.

31. The fluid delivery device of claim 28, wherein the support member has a geometry being flat, concave, convex, or tubular.

32. The fluid delivery device of claim 1, wherein the displaceable member is selected from the group consisting of a piston, a bladder, a flexible bag, a bellows, a diaphragm, a plunger, and a combination thereof.

33. The fluid delivery device of claim 32, wherein the piston comprises a tubing and a plunger.

34. The fluid delivery device of claim 33, wherein the plunger comprises a ball, a bubble, a solid, a separating fluid, a bung, or a gel.

35. The fluid delivery device of claim 1, wherein the fluid to be delivered comprises a biological, a drug, a lubricant, a fragrant fluid, a chemical agent, or a mixture thereof.

36. The fluid delivery device of claim 1 wherein the fluid is homogenous.

37. The fluid delivery device of claim 1 wherein the fluid is layered to provide intermittent delivery of an active or multiple and different actives.

38. The fluid delivery device of claim 1, wherein the fluid comprises a gel, a paste, or a suspension with or without dispersant.

39. A fluid delivery device suitable for implantation within a living body, the fluid delivery device comprising:

an electrochemical pump for transporting water, the electrochemical pump comprising an electrochemical pump product chamber configured to retain water transported by the electrochemical pump;

a control circuit operably connected to the electrochemical pump, wherein a rate of water transport being responsive to electrical current flowing through the control circuit;

an active electrode and an auxiliary electrode being in ionic communication with each other and operably connected to the control circuit;

a reservoir configured to contain a fluid to be delivered;

a displaceable member positioned between the electrochemical pump product chamber and the reservoir, wherein the displaceable member is responsive to the electrochemical pump transporting water into the electrochemical pump product chamber;

an ion-exchange membrane positioned between the active electrode and the auxiliary electrode, wherein the ion-exchange membrane is configured to transport water by osmosis and electro-osmosis between the active electrode and the auxiliary electrode into the electrochemical pump product chamber;

a diffuse membrane configured to generate increased pressure within the electrochemical pump product chamber, wherein the diffuse membrane comprises a substantially planar barrier with at least one hole therethrough having cross-sectional dimensions;

a protective porous separator being permeable to H₂0 molecules or saline and positioned such that the active electrode or the ion-exchange membrane is indirectly exposed to body tissue or body fluids; and

,

a housing containing the electrochemical pump, the displaceable member, the diffuse membrane, and the reservoir therein, wherein the auxiliary electrode is external to the housing.

40. The fluid delivery device of claim 39, wherein the protective porous separator comprises a gel.

41. A method for delivering a fluid by a fluid delivery device suitable for implantation in a living body, the method comprising:

transporting water through an ion-exchange membrane by osmosis and electro-osmosis using an electrochemical pump at a rate proportional to an output signal of a control circuit;

expanding a volume of an electrochemical pump product chamber in response to transporting the water into the electrochemical pump product chamber;

generating increased pressure within the expanded electrochemical pump product chamber using a diffuse membrane, wherein the diffuse membrane comprises a substantially planar barrier with at least one hole therethrough having cross-sectional dimensions;

displacing a displaceable member in response to the pressure in the electrochemical pump product chamber; and

controllably expelling fluid from the reservoir in response to displacement of the displaceable member.

42. The method of claim 41, further comprising adjusting a fluid delivery rate profile.

43. The method of claim 41, further comprising adjusting a fluid delivery rate.

44. The method of claim 43, wherein adjusting the fluid delivery rate further comprising changing the output signal of the control circuit.

45. The method of claim 41, further comprising activating a switch to control delivery of the fluid, wherein the switch is operably coupled between the active electrode and the auxiliary electrode.

46. A fluid delivery device, comprising:

an electrochemical pump for transporting water, the electrochemical pump comprising;

an electrochemical pump product chamber configured to retain water transported by the electrochemical pump;

an active electrode;

an auxiliary electrode configured for ionic communication with the active electrode; and

an ion-exchange membrane positioned between the active electrode and the auxiliary electrode, wherein the ion-exchange membrane is configured to transport water by osmosis and electro-osmosis between the active electrode and the auxiliary electrode into the electrochemical pump product chamber, and wherein one of the electrodes is located in the first chamber portion of the electrochemical pump product chamber, and the other electrode is located on an opposite side of the ion-exchange membrane;

a reservoir configured to contain a fluid to be delivered;

a displaceable member positioned between the electrochemical pump product chamber and the reservoir, wherein the displaceable member is responsive to the electrochemical pump transporting water into the electrochemical pump product chamber;

a diffuse membrane configured to generate increased pressure within the electrochemical pump product chamber, wherein the diffuse membrane is located within the electrochemical pump product chamber, and wherein the diffuse membrane at least partially defines a first chamber portion and a second chamber portion within the electrochemical pump product chamber;

an auxiliary electrode compartment being impermeable to body fluid, the auxiliary electrode compartment containing saline and the auxiliary electrode; and

a second displaceable member to define at least a portion of the auxiliary electrode compartment, wherein the second displaceable member is configured to retract in response to transfer of water from the auxiliary electrode compartment through the ion-conducting membrane to the electrochemical pump product chamber.

47. A fluid delivery device, comprising:

an electrochemical pump for transporting water, the electrochemical pump comprising;

an electrochemical pump product chamber configured to retain water transported by the electrochemical pump;

an active electrode;

an auxiliary electrode configured for ionic communication with the active electrode; and

an ion-exchange membrane positioned between the active electrode and the auxiliary electrode, wherein the ion-exchange membrane is configured to transport water by osmosis and electro-osmosis between the active electrode and the auxiliary electrode into the electrochemical pump product chamber, and wherein one of the electrodes is located in the first chamber portion of the electrochemical pump product chamber, and the other electrode is located on an opposite side of the ion-exchange membrane;

a reservoir configured to contain a fluid to be delivered;

a displaceable member positioned between the electrochemical pump product chamber and the reservoir, wherein the displaceable member is responsive to the electrochemical pump transporting water into the electrochemical pump product chamber; and

a diffuse membrane configured to generate increased pressure within the electrochemical pump product chamber, wherein the diffuse membrane is located within the electrochemical pump product chamber, and wherein the diffuse membrane at least partially defines a first chamber portion and a second chamber portion within the electrochemical pump product chamber; and

an auxiliary electrode compartment being impermeable to body fluid, the auxiliary electrode compartment containing saline and the auxiliary electrode, wherein the auxiliary electrode compartment is configured to collapse in response to transfer of water from the auxiliary electrode compartment through the ion-conducting membrane to the electrochemical pump product chamber.