Microfluidic device

• US 8,349,274 B2
• Filed: 10/01/2009
• Issued: 01/08/2013
• Est. Priority Date: 10/06/2008
• Status: Expired due to Fees

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Prins, Menno Willem Jose, Van Der Zaag, Pieter Jan, Den Dulk, Remco Christiaan
• Primary Examiner(s): SIEFKE, SAMUEL P
• Application Number:
  US13/120,456
• Publication Number:
  US 20110171086A1
• Time in Patent Office: 1,195 Days
• Field of Search: 422/502, 422/504, 422/68.1
• US Class Current: 422/502
• CPC Class Codes: B01L 2200/0668 Trapping microscopic beads
• CPC Class Codes: B01L 2200/10 Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/087 Multiple sequential chambers
• CPC Class Codes: B01L 2400/043 magnetic forces
• CPC Class Codes: B01L 2400/086 using baffles or other fixed flow obstructions
• CPC Class Codes: B01L 3/50273 characterised by the means or forces applied to move the fluids micropumps F04B19/006, of the membrane type F04B43/043
• CPC Class Codes: B01L 3/502738 characterised by integrated valves microvalves F16K99/0001
• CPC Class Codes: B01L 3/502761 specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules investigating characteristics of particles G01N15/00

Abstract

A microfluidic device includes chambers for performing chemical, biochemical, or physical processes and a flow path connecting the chambers. A magnetic particle is moved through the chambers which are separated by a valve-like structure that enables passing-through of the magnetic particle from one chamber to another. At least one delaying structure delays movement of the magnetic particle along the flow path.

Claims

1. A microfluidic device comprising:

a plurality of chambers adapted for performing chemical, biochemical, or physical processes;

a flow path connecting the plurality of chambers adapted for accommodating at least one magnetic particle sequentially moving through the plurality of chambers;

the plurality of chambers being separated by at least one valve-like structure adapted to enable passing-through of the at least one magnetic particle from one of the plurality of chambers to another one of the plurality of chambers; and

at least one delaying structure adapted to delay movement of the at least one magnetic particle along the flow path by stopping in a controlled manner the movement of the at least one magnetic particle and by controllably releasing the at least one magnetic particle again, wherein stopping and releasing is performed by changing a magnetic field,

wherein the delaying structure comprises a geometrical structure and is adapted such that the at least one magnetic particle is moved against the geometrical structure by application of the magnetic field, and

wherein the flow path is structured such that a direction of movement from a first of the plurality of chambers to a subsequent second of the plurality of chambers is in a first direction and a direction of movement from the second of the plurality of chambers to a subsequent third of the plurality of chambers is in a second direction, the first direction and the second direction being different and not parallel to each other.

2. The microfluidic device according to claim 1, wherein the at least one delaying structure is formed separate from the valve-like structure.

3. The microfluidic device according to claim 1, wherein valve-like structures are each provided between chambers of the plurality of chambers which are adjacent with respect to the flow path.

4. The microfluidic device according to claim 1, wherein the microfluidic device comprises a magnetic-field generating unit adapted for generating the magnetic field for moving the at least one magnetic particle through the plurality of chambers.

5. The microfluidic device according to claim 4, wherein the magnetic-field generating unit is adapted for applying the magnetic field for delaying the at least one particle.

6. The microfluidic device according to claim 1, wherein the microfluidic device comprises a plurality of processing modules each comprising a plurality of chambers and a respective flow path connecting the respective plurality of chambers adapted for accommodating magnetic particles simultaneously moving through the respective plurality of chambers.

7. The microfluidic device according to claim 6, wherein a common magnetic-field generating unit is provided for the plurality of processing modules.

8. The microfluidic device according to claim 6, wherein the processing modules are identical.

9. The microfluidic device according to claim 1, wherein individual chambers of the plurality of chambers are adapted for performing a plurality of different chemical or biochemical processes [KK1].

10. The microfluidic device of claim 1, wherein the at least one delaying structure is located centrally in the chamber.