Polymeric quaternium compounds

• US 8,349,303 B1
• Filed: 04/13/2010
• Issued: 01/08/2013
• Est. Priority Date: 04/29/2009
• Status: Expired due to Fees

• Current Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Original Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Inventors: Phillips, Eric, Kunzler, Jay F., Awasthi, Alok Kumar
• Primary Examiner(s): Padmanabhan, Sreeni
• Assistant Examiner(s): HUANG, GIGI GEORGIANA
• Application Number:
  US12/758,860
• Time in Patent Office: 1,001 Days
• Field of Search: 424/78.02
• US Class Current: 424/78.04
• CPC Class Codes: C11D 3/0078 Compositions for cleaning contact lenses, spectacles or lenses
• CPC Class Codes: C11D 3/3723 Polyamines or polyalkyleneimines

Abstract

A topical pharmaceutical composition comprising a pharmaceutical active and a polymer of general formula I or general formula II

• • wherein C_k is a saturated or unsaturated, five, six or seven-membered ring;
  • R is a C₁-C₃alkyl; n is 1, 2, 3, 4 or 5 and m provides a number average molecular weight of the polymer of from 2000 to 80,000.

Claims

1. A contact lens care solution comprising 0.5 ppm to 30 ppm of a polymer of general formula I

2. The ophthalmic composition of claim 1 wherein R is methyl.

3. The ophthalmic composition of claim 1 wherein C_k is phenyl, R is methyl, and n is 1 or 2.

4. The ophthalmic composition of claim 1 wherein C_k is phenyl, n is 1 and m provides a number average molecular weight of from 4000 to 40,000.

5. The lens care solution of claim 1 further comprising a biopolymer selected from the group consisting of hyaluronic acid, alginic acid, hydroxypropyl guar and hydroxypropylmethyl cellulose;

and a nonionic surfactant selected from a poloxamer, poloxamine or a mixture of the two.

6. The lens care solution of claim 5 wherein the biopolymer is hyaluronic acid, the hyaluronic acid provided at a concentration of 0.005 wt. % to 0.05 wt. %.

10. The ophthalmic composition of claim 1 wherein the polymer of formula I is present in the composition at a concentration of 0.5 ppm to 10 ppm.

7. The lens care solution of 5 wherein the number average molecular weight of the polymer of formula I is from 4000 to 24,000.

8. The lens care solution of 5 wherein the polymer of formula I is present in the composition at a concentration of 0.5 ppm to 10 ppm.

9. The lens care solution of 5 wherein the solution satisfies primary biocidal kill in that for a recommended disinfection period the number of bacteria recovered per mL is reduced by a mean value of not less than 3.0 logs, and the number of mold and yeast recovered per mL is reduced by a mean value of not less than 1.0 log within the recommended disinfection period.