Method for controlling perfusion of an organ
First Claim
1. A method of controlling perfusion of at least one organ with medical fluid, the method comprising:
- inputting organ data, the organ data including at least a type of organ and organ mass;
selecting one or more types of perfusion modes;
selecting a type of flow control for each selected perfusion mode;
controlling flow of the medical fluid based on the selected perfusion mode and flow control;
detecting operating conditions experienced by the medical fluid and organ during perfusion;
comparing detected operating conditions with prestored operating conditions and generating a signal indicative of organ viability based on the comparison; and
generating a message relating to organ viability and/or making automatic adjustments to regulate viability based on the signal generated by the comparison.
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Abstract
An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.
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Citations
12 Claims
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1. A method of controlling perfusion of at least one organ with medical fluid, the method comprising:
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inputting organ data, the organ data including at least a type of organ and organ mass; selecting one or more types of perfusion modes; selecting a type of flow control for each selected perfusion mode; controlling flow of the medical fluid based on the selected perfusion mode and flow control; detecting operating conditions experienced by the medical fluid and organ during perfusion; comparing detected operating conditions with prestored operating conditions and generating a signal indicative of organ viability based on the comparison; and generating a message relating to organ viability and/or making automatic adjustments to regulate viability based on the signal generated by the comparison. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification