Methods of determining patient response by measurement of Her-3
First Claim
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1. A method for determining whether a subject with a cancer is likely to respond to treatment with a Her family targeted agent, for predicting a time course of disease during treatment with a Her family targeted agent, and/or for predicting the probability of a significant event in the time course of the subject'"'"'s cancer during treatment with a Her family targeted agent, comprising:
- (a) obtaining a biological sample from of the subject'"'"'s cancer;
(b) measuring the amount of Her-3 in the biological sample using a Her-3 antibody that specifically binds to a polypeptide sequence set forth in one of SEQ ID NOs 1-8;
(c) determining whether the amount of Her-3 in the subject'"'"'s sample is above a Her-3 cutoff;
(d) correlating the amount of Her-3 measured in the biological sample to at least one of determining the relative likelihood of whether a subject with a Her-2 positive cancer will respond to treatment with a Her-family targeted agent, predicting a time course of disease during treatment with a Her family targeted agent, and/or predicting a probability of a significant event in the time course of the subject'"'"'s cancer during treatment with a Her family targeted agent; and
(e) indicating that the subject is more likely to respond to the Her family targeted agent, more likely to have a long time course during treatment with a Her family targeted agent, and/or less likely to have a significant event during treatment with a Her family targeted agent if the amount of Her-3 in the biological sample is below the Her-3 cutoff as compared to if the Her-3 in the biological sample is above the Her-3 cutoff.
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Abstract
The invention provides methods of measuring and/or quantifying the presence and/or amount of Her-3 and/or Her-3 in a complex in a sample. The invention also provides antibodies specific for Her-3.
135 Citations
51 Claims
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1. A method for determining whether a subject with a cancer is likely to respond to treatment with a Her family targeted agent, for predicting a time course of disease during treatment with a Her family targeted agent, and/or for predicting the probability of a significant event in the time course of the subject'"'"'s cancer during treatment with a Her family targeted agent, comprising:
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(a) obtaining a biological sample from of the subject'"'"'s cancer; (b) measuring the amount of Her-3 in the biological sample using a Her-3 antibody that specifically binds to a polypeptide sequence set forth in one of SEQ ID NOs 1-8; (c) determining whether the amount of Her-3 in the subject'"'"'s sample is above a Her-3 cutoff; (d) correlating the amount of Her-3 measured in the biological sample to at least one of determining the relative likelihood of whether a subject with a Her-2 positive cancer will respond to treatment with a Her-family targeted agent, predicting a time course of disease during treatment with a Her family targeted agent, and/or predicting a probability of a significant event in the time course of the subject'"'"'s cancer during treatment with a Her family targeted agent; and (e) indicating that the subject is more likely to respond to the Her family targeted agent, more likely to have a long time course during treatment with a Her family targeted agent, and/or less likely to have a significant event during treatment with a Her family targeted agent if the amount of Her-3 in the biological sample is below the Her-3 cutoff as compared to if the Her-3 in the biological sample is above the Her-3 cutoff. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A method for determining whether a subject with a cancer is likely to respond to treatment with a Her family targeted agent, for predicting a time course of disease during treatment with a Her family targeted agent, and/or for predicting the probability of a significant event in the time course of the subject'"'"'s cancer during treatment with a Her family targeted agent, comprising:
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(a) obtaining a biological sample from the subject'"'"'s cancer; (b) measuring the amount of Her-3 and p95 in the biological sample, wherein the amount of Her-3 antibody that specifically binds to a polypeptide sequence set forth in one of SEQ ID NOs 1-8; (c) determining whether the amount of Her-3 in the subject'"'"'s sample is above a Her-3 cutoff and whether the p95 in the subject'"'"'s sample is above a p95 cutoff; and (d) correlating the amount of Her-3 and p95 measured in the biological sample to at least one of determining the relative likelihood of whether a subject with a Her-2 positive cancer will respond to treatment with a Her-family targeted agent, predicting a time course of disease during treatment with a Her family targeted agent, and/or predicting a probability of a significant event in the time course of the subject'"'"'s cancer during treatment with a Her family targeted agent; and (e) indicating that the subject is more likely to respond to the Her family targeted agent, more likely to have a long time course during treatment with a Her family targeted agent, and/or less likely to have a significant event during treatment with a Her family targeted agent if the amount of Her-3 in the biological sample is below the Her-3 cutoff than if the Her-3 and/or p95 in the biological sample are above their respective cutoffs. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51)
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Specification