Diagnostic devices
First Claim
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1. A platform comprising one or more dry porous membranes for detecting at least one component in a liquid sample, wherein:
- the platform is formed from top and bottom layers comprising respective top and bottom hydrophilic surfaces that are brought into fixed face to face contact to enclose and position the membranes and form a platform flow channel and a sample application means; and
the platform flow channel is in fluid communication with the membranes and is configured to promote increased capillary force and uniform flow of the sample by capillary action in a continuous pathway from the sample application means through the platform flow channel and then to an edge of an upstream end of the membranes towards the distal end of said membranes.
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Abstract
The present invention relates to analytical methods, platforms, and devices for the rapid and efficient immunochromatic determination of one or more components in fluid samples.
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Citations
20 Claims
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1. A platform comprising one or more dry porous membranes for detecting at least one component in a liquid sample, wherein:
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the platform is formed from top and bottom layers comprising respective top and bottom hydrophilic surfaces that are brought into fixed face to face contact to enclose and position the membranes and form a platform flow channel and a sample application means; and the platform flow channel is in fluid communication with the membranes and is configured to promote increased capillary force and uniform flow of the sample by capillary action in a continuous pathway from the sample application means through the platform flow channel and then to an edge of an upstream end of the membranes towards the distal end of said membranes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 17, 18, 19, 20)
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8. A platform comprising a detection membrane and a capture membrane for rapid and efficient detection of one or more components in a whole blood sample, wherein:
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the detection membrane is constructed to filter substantially all of the red blood cells from the sample and contains a mobile labeled detecting reagent which will react with the one or more components to form a reaction product which moves downstream in the detection membrane; the capture membrane is downstream of the detection membrane and contains a fixed, immobile capture reagent which reacts with and concentrates the reaction product at a capture line, the downstream end of the detection membrane overlapping the upstream end of the capture membrane; the platform is formed from top and bottom layers comprising respective top and bottom hydrophilic surfaces that are brought into fixed face to face contact to enclose and position the membranes and form a platform flow channel and a sample application means; and the platform flow channel is in fluid communication with the membranes and is configured to promote increased capillary force and uniform flow of the sample by capillary action in a continuous pathway from the sample application means through the platform flow channel and then to an edge of the upstream end of the detection membrane towards the downstream end of the capture membrane. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16)
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Specification