Destruction of microbial products by enzymatic digestion
First Claim
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1. A method of treating a dialysis component, the method comprising:
- providing a dialysis component for peritoneal dialysis;
contacting the dialysis component with an enzyme selected from the group consisting of N-acetylmuramyl-L-alanine amidase, lysozyme, amidases, trypsins, chitinases, beta 1-3 glucanases, pronases, proteases, lipases, endoglycosidases and combinations thereof;
allowing the enzyme to break down microbial contaminants in the dialysis component; and
separating the enzyme from the dialysis component to provide a purified dialysis component.
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Abstract
Methods of treating a dialysis component by providing a dialysis component and contacting the dialysis component with an enzyme are provided. The enzyme breaks down microbial contaminants in the dialysis component. The enzyme may be separated from the dialysis component to provide a purified dialysis component. The purified dialysis component may be substantially free of microbial contaminants that cause a cytokine response in humans.
31 Citations
21 Claims
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1. A method of treating a dialysis component, the method comprising:
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providing a dialysis component for peritoneal dialysis; contacting the dialysis component with an enzyme selected from the group consisting of N-acetylmuramyl-L-alanine amidase, lysozyme, amidases, trypsins, chitinases, beta 1-3 glucanases, pronases, proteases, lipases, endoglycosidases and combinations thereof; allowing the enzyme to break down microbial contaminants in the dialysis component; and separating the enzyme from the dialysis component to provide a purified dialysis component. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of treating a peritoneal dialysis solution, the method comprising:
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providing a peritoneal dialysis solution comprising a glucose polymer, hydroxyethyl starch or modified starch; contacting the peritoneal dialysis solution with an enzyme selected from the group consisting of N-acetylmuramyl-L-alanine amidase, lysozyme, amidases, trypsins, chitinases, beta 1-3 glucanases, pronases, proteases, lipases, endoglycosidases and combinations thereof; allowing the enzyme to break down microbial contaminants in the peritoneal dialysis solution; and separating the enzyme from the peritoneal dialysis solution to provide a purified peritoneal dialysis solution. - View Dependent Claims (19, 20)
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21. A method of providing peritoneal dialysis to a patient, the method comprising:
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providing a peritoneal dialysis component comprising a glucose polymer, hydroxyethyl starch or modified starch; contacting the peritoneal dialysis component with an enzyme selected from the group consisting of N-acetylmuramyl-L-alanine amidase, lysozyme, amidases, trypsins, chitinases, beta 1-3 glucanases, pronases, proteases, lipases, endoglycosidases and combinations thereof; allowing the enzyme to break down microbial contaminants in the peritoneal dialysis component; separating the enzyme from the peritoneal dialysis component to provide a purified peritoneal dialysis component; using the purified peritoneal dialysis component to make a peritoneal dialysis solution; and using the peritoneal dialysis solution in a treatment of a patient.
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Specification