Noninvasive blood analysis by optical probing of the veins under the tongue

• US 8,352,005 B2
• Filed: 04/24/2008
• Issued: 01/08/2013
• Est. Priority Date: 04/24/2003
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Esenaliev, Rinat O., Prough, Donald S.
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US12/150,108
• Publication Number:
  US 20080281173A1
• Time in Patent Office: 1,720 Days
• Field of Search: 600/310, 600/322, 600/340, 600/344
• US Class Current: 600/322
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0068 Confocal scanning
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14535 for measuring haematocrit
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/682 Mouth, e.g., oral cavity; tongue; Lips; Teeth

Abstract

A method for analysis of blood components or parameters is disclosed where a probe having an excitation outlet and a response inlet is placed in proximity to or in contact with a tissue of an underside of a patient'"'"'s tongue over a big vein in the tongue so that an excitation signal exits the outlet, produces a response which enters the inlet for detection and analysis.

Claims

1. A method for noninvasive analysis of at least one blood component in venous blood comprising the steps of:

placing a probe in contact with a surface of a tissue directly under a big vein associated with an underside of a patient'"'"'s tongue, where the probe includes a tip having a radiation outlet and a response inlet so that both the radiation outlet and the response inlet are simultaneously in contact with the surface and where the outlet is connected to a light source via a light source conduit and the inlet is connected to a detector via a response conduit;

irradiating venous blood in the big vein with radiation having at least one frequency or wavelength;

detecting a response from the venous blood irradiated in the irradiating step; and

calculating a concentration of a blood component, a value of a blood parameter or a mixture or combination thereof in the venous blood from the response.

2. The method of claim 1, further comprising the step of:

displaying the response, the concentration and/or the value from the calculating step.

3. The method of claim 1, wherein the detecting step comprises the step of:

utilizing one or a combination of techniques selected from the group consisting of reflectance technique, confocal technique, scanning confocal technique, polarization techniques, interferometry, optoacoustics, low coherence interferometry and reflectometry, techniques based on speckle measurements, fluorescence, Raman scattering, and a two or multi-photon technique.

4. The method of claim 1, wherein the wavelength of the radiation is from about 200 nanometers to about 20 microns.

5. The method of claim 1, wherein the response corresponds to a concentration of hemoglobin in the blood and the wavelength of the radiation is selected from the group consisting of 548 nm, 568 nm, 587 nm, and 805 nm, a wavelength in a range from about 400 nm to about 640 nm, and a wavelength in a range from about 520 nm to about to about 1700.

6. The method of claim 1, wherein the radiation has a plurality of wavelengths or frequencies.

7. The method of claim 1, wherein the response corresponds to a concentration of hemoglobin in the blood and the wavelength of the radiation is in a range from 250 to 2500 nm.

8. The method of claim 1, wherein the blood component and/or value of a parameter of the blood is selected from the group consisting of hematocrit, hemoglobin, glycosylated hemoglobin, glucose, cholesterol, oxy-hemoglobin, deoxy-hemoglobin, carboxy-hemoglobin, an exogenous substance, and combinations thereof.

9. The method of claim 8, wherein the exogenous substance is selected from the group consisting of one or more of:

a drug;

a dye or other reporter in a molecular state;

particles made of liquid, gas or solid materials and combinations thereof; and

a layered structure.

10. The method of claim 9, wherein the exogenous substance is a dye selected from the group consisting of indocyanine green and Evans blue.

11. The method of claim 9, wherein the exogenous substance is particles having a size from about 0.1 nanometer to about 10 microns.

12. The method of claim 1, further comprising:

performing the detecting step in the presence of a static electric or magnetic field.

13. The method of claim 1, wherein the radiation outlet comprises an end of the light source conduit and the response inlet comprises an end of the response conduit.

14. The method of claim 13, wherein the light source conduit and the response conduit comprise one optical fiber or a plurality of optical fibers.

15. The method of claim 1, wherein the probe comprises at least one radiation outlet and a plurality of response inlets.