Diagnosing hypoxia by monitoring changes in oxygen saturation

• US 8,352,006 B1
• Filed: 07/24/2007
• Issued: 01/08/2013
• Est. Priority Date: 05/05/2003
• Status: Active Grant

• Current Assignee: ViOptix, Inc.
• Original Assignee: ViOptix, Inc.
• Inventors: Elmandjra, Mohamed, O'Keefe, William, Mao, Jian-min, Bush, Robin, Christenson, Linda
• Primary Examiner(s): Mallari, Patricia
• Assistant Examiner(s): D'Angelo, Michael
• Application Number:
  US11/782,394
• Time in Patent Office: 1,995 Days
• Field of Search: 600/481, 600/500, 600/323
• US Class Current: 600/323
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14551 for measuring blood gases

Abstract

Hypoxia is diagnosed through measurements of oxygen saturation. Some examples of hypoxia conditions that may be diagnosed include peripheral vascular disease, multiple organ dysfunction syndrome, ischemia, hypotension, and arteriosclerosis. In a specific implementation, a hypoxia condition is diagnosed based on changes in oxygen saturation in tissue. Ischemia is induced, and then measurements of changes in oxygen saturation in tissue are made. Based on changes in oxygen saturation, a diagnosis is provided of whether a patient has or does not have a hypoxia condition.

Claims

1. A method of diagnosing a peripheral vascular disease condition comprising:

measuring oxygen saturation in tissue of a patient;

analyzing the oxygen saturation in the tissue; and

determining a rate of change of the oxygen saturation in the tissue

using at least one processor, diagnosing the patient as having the peripheral vascular disease condition based on the rate of change of the oxygen saturation crossing a value in the tissue.

2. The method of claim 1 wherein the peripheral vascular disease condition comprises multiple organ dysfunction syndrome.

3. The method of claim 1 wherein the measuring of the oxygen saturation occurs during induced ischemia.

4. The method of claim 3 wherein the measuring of the oxygen saturation occurs during a recovery phase of the induced ischemia.

5. The method of claim 4 wherein during the recovery phase, the rate of change is a positive number when the oxygen saturation in the tissue increases over time.

6. The method of claim 3 wherein during induced ischemia, the rate of change is a negative number when the oxygen saturation in the tissue falls over time, and after the induced ischemia, the rate of change becomes a positive number when the oxygen saturation in the tissue increases over time.

7. The method of claim 1 wherein the measuring of the oxygen saturation is determined using continuous wave spectroscopy.

8. The method of claim 1 wherein the measuring of the oxygen saturation is determined by irradiating a physiological medium with at least one wave source and detecting using at least one wave detector.

9. The method of claim 8 wherein during the irradiating, the at least one wave source outputs at least two electromagnetic waves having different wave characteristics.

10. The method of claim 8 wherein during the detecting, the at least one wave detector receives electromagnetic radiation transmitted through a physiological medium.

11. The method of claim 8 wherein a first distance between a first wave source and a first wave detector is equal to a second distance between a second wave source and a second wave detector.

12. The method of claim 1 wherein the analyzing the oxygen saturation in the tissue is based on an absolute value of chromophores.

13. The method of claim 1 wherein the analyzing the oxygen saturation in the tissue is based on a ratio of chromophore concentrations.

14. The method of claim 1 wherein the rate of change of the oxygen saturation in the tissue is measured at a single tissue site.

15. The method of claim 1 wherein the diagnosing the patient as having the peripheral vascular disease condition based on the rate of change of the oxygen saturation in the tissue comprises:

making a positive diagnosis of a peripheral vascular condition when the rate of change in the oxygen saturation crosses a threshold value.

16. A method comprising:

measuring oxygen saturation of the tissue of the patient;

determining a rate of change of the oxygen saturation in the tissue; and

using at least one processor, diagnosing the patient as having a peripheral vascular disease condition based on the rate of change of the oxygen saturation crossing a value in the tissue during at least one phase of ischemia.

17. The method of claim 16 comprising:

inducing ischemia in tissue of a patient.

18. The method of claim 17 wherein the measuring of the oxygen saturation occurs during a recovery phase of induced ischemia.

19. The method of claim 18 wherein during the recovery phase, the rate of change is a positive number when the oxygen saturation in the tissue increases over time.

20. The method of claim 18 wherein during induced ischemia, the rate of change is a negative number when the oxygen saturation in the tissue falls over time, and after the induced ischemia, the rate of change becomes a positive number when the oxygen saturation in the tissue increases over time.

21. A system comprising:

a probe comprising a first detector input;

a computer, coupled to process signals received via the first detector input, to determine a rate of change of oxygen saturation crossing a value in tissue of a patient and make a diagnosis of a peripheral vascular disease based on the rate of change crossing a value; and

a display, coupled to the computer, to provide a visual indication of a positive diagnosis of peripheral vascular disease.

22. The system of claim 21 wherein the diagnosis of a peripheral vascular disease is positive when the computer determines the rate of change in the oxygen saturation crosses a threshold value.

23. The system of claim 22 wherein the threshold value is a rate of change in oxygen saturation in the tissue.

24. The system of claim 22 wherein when the rate of change crosses the threshold value, the patient has the peripheral vascular disease condition.

25. The system of claim 21 wherein the probe comprises a second detector input, a first source output, and a second source output, and a first distance between the first detector input and the first source output is substantially the same as a second distance between the second detector input and the second source output.

26. The system of claim 22 wherein the rate of change in the oxygen saturation is measured during induced ischemia of the tissue.

27. The system of claim 22 wherein the rate of change in the oxygen saturation is measured during a recovery phase of induced ischemia of the tissue, wherein the rate of change is a positive number.

28. The system of claim 27 wherein the rate of change is measured at a midpoint in the recovery phase, when the oxygen saturation in the tissue is halfway between a lowest value of oxygen saturation during induced ischemia and a baseline value before the induced ischemia.

29. The system of claim 27 wherein the rate of change is inversely related to a likelihood of a positive diagnosis of a hypoxia condition.

30. The system of claim 26 wherein the rate of change in the oxygen saturation rises above the threshold value.

31. The system of claim 21 comprising measuring the oxygen saturation in tissue during a recovery phase of induced ischemia, and the rate of change is a positive number when the oxygen saturation in the tissue increases over time during the recovery phase.

32. The method of claim 31 wherein during induced ischemia, the rate of change is a negative number when the oxygen saturation in the tissue falls over time, and after the induced ischemia, the rate of change becomes a positive number when the oxygen saturation in the tissue increases over time.