Non-invasive subject-information imaging method and apparatus

• US 8,353,830 B2
• Filed: 03/31/2004
• Issued: 01/15/2013
• Est. Priority Date: 02/06/2004
• Status: Active Grant

• Current Assignee: Toshiba Medical Systems Corporation (Canon Inc.)
• Original Assignee: Toshiba Medical Systems Corporation (Canon Inc.), Kabushiki Kaisha Toshiba (Toshiba Corporation)
• Inventors: Kanayama, Shoichi, Itsumi, Kazuhiro
• Primary Examiner(s): Cwern, Jonathan
• Application Number:
  US10/812,884
• Publication Number:
  US 20050187471A1
• Time in Patent Office: 3,212 Days
• Field of Search: 600/407, 600/427, 600/437, 600/439, 600/459, 600/473, 600/476
• US Class Current: 600/437
• CPC Class Codes: A61B 2562/046 in a matrix array
• CPC Class Codes: A61B 5/0035 adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
• CPC Class Codes: A61B 5/0091 for mammography
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/4312 Breast evaluation or disorder diagnosis A61B5/0091 takes precedence
• CPC Class Codes: A61B 8/14 Echo-tomography
• CPC Class Codes: A61B 8/5238 for combining image data of patient, e.g. merging several images from different acquisition modes into one image for image registration algorithms G06T7/30
• CPC Class Codes: G01N 2291/02809 Concentration of a compound, e.g. measured by a surface mass change
• CPC Class Codes: G01N 29/0609 Display arrangements, e.g. colour displays indicating or recording in connection with measuring in general G01D

Abstract

A non-invasive subject-information imaging apparatus according to this invention includes a light generating unit which generates light containing a specific wavelength component, a light irradiation unit which radiates the generated light into a subject, a waveguide unit which guides the light from the light generating unit to the irradiation unit, a plurality of two-dimensionally arrayed electroacoustic transducer elements, a transmission/reception unit which transmits ultrasonic waves to the subject by driving the electroacoustic transducer elements, and generates a reception signal from electrical signals converted by electroacoustic transducer elements, and a signal processing unit which generates volume data about a living body function by processing a reception signal corresponding to acoustic waves generated in the subject by light irradiation, and generates volume data about a tissue morphology by processing a reception signal corresponding to echoes generated in the subject upon transmission of the ultrasonic waves.

Claims

1. A non-invasive subject-information imaging apparatus comprising:

a light generating unit configured to output light at a plurality of wavelengths and to multiplex the output light on a single optical axis;

a light irradiation unit configured to irradiate the light generated by the light generating unit into a subject to be examined;

a waveguide including a plurality of optical fibers configured to guide the light generated by the light generating unit to the irradiation unit;

electroacoustic transducer elements including a plurality of two-dimensionally arrayed conversion elements, and configured to convert acoustic waves from the subject into electrical signals;

transmission means for transmitting ultrasonic waves to the subject by driving said plurality of electroacoustic transducer elements;

reception means for generating a reception signal having reception directivity from said plurality of electrical signals converted by said plurality of electroacoustic transducer elements;

an electronic switch;

signal processing means for generating volume data about a living body function by processing a reception signal corresponding to acoustic waves generated in the subject by light radiated from the irradiation unit and received by a predetermined number of conversion elements, and for generating volume data about a tissue morphology by processing a reception signal corresponding to echoes generated in the subject upon transmission of the ultrasonic waves; and

optical scanning means for sequentially selecting an end portion from said plurality of end portions of said plurality of optical fibers to irradiate the subject with light;

wherein

said plurality of optical fibers are two-dimensionally laid in gaps between said plurality of conversion elements such that each optical fiber is surrounded by four adjacent conversion elements, said plurality of conversion elements vertically and horizontally arrayed, the irradiation unit is formed from a plurality of end portions of said plurality of optical fibers, and the reception means generates a reception signal, corresponding to acoustic waves generated by irradiation of the light, from electrical signals from the predetermined number of conversion elements adjacent an end portion of the selected optical fiber which has radiated the light,

the electronic switch selects all of the conversion elements or a subset of adjacent conversion elements to transmit the ultrasonic waves, and selects the predetermined number of conversion elements for reception of echoes of the ultrasonic waves, and

the electronic switch supplies to the reception means the electrical signals generated by the predetermined number of conversion elements in response to the acoustic waves generated by irradiation of the light, the predetermined number of conversion elements used to receive the acoustic waves generated in the subject by light radiated from the irradiation unit selected by the switch in accordance with a control signal from a conversion element selection control unit.

2. An apparatus according to claim 1, further comprising optical scanning means for simultaneously radiating light beams from end portions of not less than two optical fibers whose end portions are spaced apart by not less than a predetermined distance.

3. An apparatus according to claim 2, wherein the reception means generates a reception signal corresponding to acoustic waves generated by irradiation of the light, from electrical signals from a predetermined number of conversion elements near an end portion of an optical fiber which has radiated the light.

4. An apparatus according to claim 1, wherein light beams are simultaneously radiated from said plurality of end portions of said plurality of optical fibers.

5. An apparatus according to claim 4, wherein the reception means generates a reception signal, corresponding to the end portion of said each optical fiber, from electrical signals from a predetermined number of conversion elements near the end portion of said each optical fiber.

6. An apparatus according to claim 1, wherein photoacoustic scanning for generating volume data about the living body function by irradiation of light from the end portion of the optical fiber and detection of an acoustic wave generated upon irradiation of the light by the conversion element, and ultrasonic scanning for generating volume data about the tissue morphology by transmission of an ultrasonic wave by the conversion element and detection of an echo are alternately performed.

7. An apparatus according to claim 1, wherein irradiation of light from the end portion of the optical fiber which is performed to generate volume data about the living body function and transmission of an ultrasonic wave by the conversion element which is performed to generate volume data about the tissue morphology are alternately performed.

8. An apparatus according to claim 1, wherein the signal processing means generates living body function image data and tissue morphology image data about a single slice from volume data about the living body function and volume data about the tissue morphology.

9. An apparatus according to claim 8, wherein the living body function image data and the tissue morphology image data are displayed side by side on a single screen.

10. An apparatus according to claim 8, wherein the living body function image data and the tissue morphology image data are superimposed and displayed.

11. An apparatus according to claim 1, wherein the light generating unit further comprises a multiplexing unit configured to multiplex the light output at the plurality of wavelengths on a single optical axis.

12. An apparatus according to claim 1, wherein the light generating unit is an optical parametrical oscillator laser.

13. A non-invasive subject-information imaging method comprising:

outputting light at a plurality of wavelengths and multiplexing the output light on a single optical axis;

irradiating a subject to be examined with the light using a plurality of optical fibers having two-dimensionally arranged light irradiation positions, the irradiating including sequentially selecting an optical fiber from said plurality of optical fibers to irradiate the subject;

receiving, using a plurality of two-dimensionally arranged conversion elements, acoustic waves generated in the subject upon the irradiation of light;

selecting all of the conversion elements or a subset of adjacent conversion elements to transmit ultrasonic waves;

driving said plurality of selected conversion elements to transmit the ultrasonic waves in a plurality of directions corresponding to said plurality of light irradiation positions;

selecting a predetermined number of conversion elements for reception of echoes of the ultrasonic waves and acoustic waves generated in the subject by light irradiation;

receiving, using said plurality of selected conversion elements, echoes of the ultrasonic waves and the acoustic waves generated in the subject by light irradiation;

generating a reception signal corresponding to acoustic waves generated by irradiation of the light, from electrical signals from the predetermined number of conversion elements adjacent an end portion of the selected optical fiber which has radiated the light, the predetermined number of conversion elements selected in accordance with a control signal from a conversion element selection control unit;

generating volume data about a living body function of the subject on the basis of the reception signal corresponding to the acoustic waves; and

generating volume data about a tissue morphology of the subject on the basis of a reception signal corresponding to the echoes;

wherein said plurality of optical fibers are two-dimensionally laid in gaps between said plurality of conversion elements such that each optical fiber is surrounded by four adjacent conversion elements, said plurality of conversion elements vertically and horizontally arrayed.

14. A method according to claim 13, wherein the light is simultaneously radiated from a predetermined number of discrete light irradiation positions of said plurality of light irradiation positions.

15. A method according to claim 13, wherein the irradiation of light and the transmission of an ultrasonic wave are alternately performed.

16. A method according to claim 13, wherein said driving step includes selecting all of the conversion elements or a subset of adjacent conversion elements to transmit the ultrasonic waves, and said receiving step includes selecting the predetermined number of conversion elements for reception of echoes of the ultrasonic waves.