Systems and methods for ultrasound treatment of thyroid and parathyroid
First Claim
1. A method for treating disorders of thyroid and/or parathyroid with HIFU in a subject in need thereof comprising(i) identifying a treatment zone to which ultrasonic energy should be applied to, said treatment zone including at least a part of the parathyroid and(ii) directing high intensity focused ultrasound energy, with an energy level sufficient to cause tissue necrosis, towards said treatment zonethe method comprising the further step of monitoring values of at least one blood level selected from the group of parathyroid hormone blood level, calcium blood level, blood phosphorous level, TSH hormone blood level, T3 hormone blood level and T4 hormone blood level of a patient.
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Abstract
A treatment device and methods for HIFU treatment of thyroid and parathyroid disorders are provided. The treatment method includes steps of identifying a treatment zone and directing high intensity focused ultrasound energy towards the treatment zone. The treatment device has a first sensor for detecting swallowing motion and a second sensor for tracking the motion of the thyroid and parathyroid tissue with ultrasound imaging.
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Citations
19 Claims
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1. A method for treating disorders of thyroid and/or parathyroid with HIFU in a subject in need thereof comprising
(i) identifying a treatment zone to which ultrasonic energy should be applied to, said treatment zone including at least a part of the parathyroid and (ii) directing high intensity focused ultrasound energy, with an energy level sufficient to cause tissue necrosis, towards said treatment zone the method comprising the further step of monitoring values of at least one blood level selected from the group of parathyroid hormone blood level, calcium blood level, blood phosphorous level, TSH hormone blood level, T3 hormone blood level and T4 hormone blood level of a patient.
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2. A method for treating primary or secondary hyperparathyroidism comprising the steps of
(i) identifying a treatment zone to which ultrasonic energy should be applied to, said treatment zone including at least a part of the parathyroid, (ii) directing high intensity focused ultrasound energy, with an energy level sufficient to cause tissue necrosis, toward said treatment zone, and (iii) monitoring a value of at least one blood level from the group of parathyroid hormone blood level, calcium blood level and blood phosphorus level.
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16. A method for modifying a parathyroid tissue comprising the steps of
(i) identifying a treatment zone to which ultrasonic energy should be applied to, said treatment zone including at least a part of the parathyroid, (ii) directing high intensity focused ultrasound energy, with an energy level sufficient to cause tissue necrosis, towards the treatment zone, and (iii) monitoring a value of at least one blood level selected from the group of parathyroid hormone blood level, calcium blood level and blood phosphorus level.
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17. A method for treating disorders of thyroid and/or parathyroid with HIFU in a subject in need thereof comprising the steps of:
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(i) identifying a treatment zone to which ultrasonic energy should be applied to, said treatment zone including at least a part of the parathyroid and (ii) directing high intensity focused ultrasound energy, with an energy level sufficient to cause tissue necrosis, towards said treatment zone, wherein said ultrasound energy is directed towards said treatment zone as a series of a least two pluses separated by pauses wherein said pauses are selected in such a way as to allow for prefocal tissue to return to normal temperature thereby avoiding or skin burn.
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18. A method for treating a subject with HIFU, said method comprising steps of:
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(i) identifying a treatment zone to which ultrasonic energy should be applied and (ii) directing high intensity focused ultrasound energy toward said treatment zone, wherein said ultrasound energy is directed towards said treatment zone as a series of at least two pulses separated by pauses, and wherein the pauses are determined according to the following formula; - View Dependent Claims (19)
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Specification