Raman spectroscopy for non-invasive glucose measurements
First Claim
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1. A method of processing Raman spectral data comprising:
- obtaining an array of Raman spectral data collected through a first skin layer of a patient;
binning the Raman spectral data;
comparing the binned Raman spectral data from the first skin layer with measured Raman spectral data from a second skin layer underlying the first layer, the Raman spectral data including a plurality of analytes within at least one of the first skin layer and the second skin layer; and
based on said comparing step, determining a concentration of glucose within a region of tissue underlying the first skin layer with the measured Raman spectral data.
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Abstract
The present invention relates to the use of Raman spectroscopy for quantitative, non-invasive transcutaneous measurement of blood analytes, such as glucose. Raman spectroscopy is used to measure glucose transcutaneously, in patients whose blood glucose levels were monitored. Raman spectra were collected transcutaneously along with glucose reference values provided by standard capillary blood analysis. A partial least squares calibration was created from the data from each subject and validated using leave-one-out cross validation.
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Citations
26 Claims
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1. A method of processing Raman spectral data comprising:
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obtaining an array of Raman spectral data collected through a first skin layer of a patient; binning the Raman spectral data; comparing the binned Raman spectral data from the first skin layer with measured Raman spectral data from a second skin layer underlying the first layer, the Raman spectral data including a plurality of analytes within at least one of the first skin layer and the second skin layer; and based on said comparing step, determining a concentration of glucose within a region of tissue underlying the first skin layer with the measured Raman spectral data. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A method of processing Raman spectral data comprising:
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obtaining an array of Raman spectral data collected through a first skin layer of a patient; processing the Raman spectral data; comparing the processed Raman spectral data from the first skin layer with measured Raman spectral data from a second skin layer underlying the first layer; and based on said comparing step, determining a concentration of glucose within a region of tissue underlying the first skin layer with the measured Raman spectral data. - View Dependent Claims (24, 25, 26)
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Specification