Systems and methods for performing peritoneal dialysis

• US 8,357,113 B2
• Filed: 09/18/2009
• Issued: 01/22/2013
• Est. Priority Date: 07/19/2002
• Status: Expired due to Term

• Current Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Original Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Inventors: Childers, Robert W., Brown, David S., Wariar, Ramesh, Din, Shahid, Martis, Leo, Buckmann, Cody, Soltys, Paul, Karoor, Sujatha
• Primary Examiner(s): SHUMATE, VICTORIA PEARL
• Application Number:
  US12/562,730
• Publication Number:
  US 20100010429A1
• Time in Patent Office: 1,222 Days
• Field of Search: 604/5.04, 604/6.09, 604/29, 210/433.1, 210/434, 210/646
• US Class Current: 604/29
• CPC Class Codes: A61M 1/1524 the interface providing means for actuating on functional elements of the cassette, e.g. plungers
• CPC Class Codes: A61M 1/153 the cassette being adapted for heating or cooling the treating fluid, e.g. the dialysate or the treating gas
• CPC Class Codes: A61M 1/154 with sensing means or components thereof
• CPC Class Codes: A61M 1/155 with treatment-fluid pumping means or components thereof
• CPC Class Codes: A61M 1/1561 at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
• CPC Class Codes: A61M 1/1565 Details of valves
• CPC Class Codes: A61M 1/159 specially adapted for peritoneal dialysis
• CPC Class Codes: A61M 1/1656 Apparatus for preparing dialysates
• CPC Class Codes: A61M 1/1658 Degasification
• CPC Class Codes: A61M 1/166 Heating for sterilisation A61M1/1686
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 1/284 Continuous flow peritoneal dialysis [CFPD]
• CPC Class Codes: A61M 1/285 Catheters therefor
• CPC Class Codes: A61M 1/287 Dialysates therefor
• CPC Class Codes: A61M 1/288 Priming priming in extracorporeal blood circuits A61M1/3643
• CPC Class Codes: A61M 2202/0413 Blood
• CPC Class Codes: A61M 2205/12 with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/3327 Measuring

Abstract

A regenerative peritoneal dialysis system includes a dialysis fluid loop; a filter located in the dialysis fluid loop, a first portion of the dialysis fluid sent to the filter rejected by the filter and returned upstream of the filter, a second portion of the dialysis fluid sent to the filter forming permeate, the permeate being rich in urea; and a urea removing apparatus located in the dialysis fluid loop downstream from the filter to receive the permeate and absorb urea from the permeate.

Claims

1. A regenerative peritoneal dialysis system comprising:

a patient loop for fluid communication with a patient;

a regeneration loop in fluid communication with the patient loop;

a filter located in the regeneration loop, a first portion of fluid sent to the filter rejected by the filter and returned upstream of the filter, a second portion of the fluid sent to the filter forming permeate, the permeate being rich in urea; and

a cartridge located in the regeneration loop so as to receive the permeate, the cartridge including a medium configured to absorb urea from the permeate.

2. The regenerative peritoneal dialysis system of claim 1, wherein the medium is a sorbent material configured to absorb urea, a reverse osmosis medium or an electrooxidation medium.

3. The regenerative peritoneal dialysis system of claim 1, wherein the filter is a nanofilter.

4. The regenerative peritoneal dialysis system of claim 1, wherein the regeneration loop communicates fluidly with the patient loop via a solution container.

5. The regenerative peritoneal dialysis system of claim 4, wherein the solution container receives the rejected first portion of fluid returned upstream of the filter.

6. The regenerative peritoneal dialysis system of claim 4, wherein fluid exiting the cartridge is returned to the solution container.

7. The regenerative peritoneal dialysis system of claim 1, wherein the patient fluid loop includes a cleaning cartridge having at least one of:

(i) activated charcoal and (ii) an anion exchange.

8. The regenerative peritoneal dialysis system of claim 7, wherein the cleaning cartridge is located upstream of a fluid communication junction between the patient loop and the regeneration loop.

9. The regenerative peritoneal dialysis system of claim 1, wherein the patient fluid loop includes a filter.

10. The regenerative peritoneal dialysis system of claim 9, wherein the filter is located downstream of a fluid communication junction between the patient loop and the generation loop.

11. The regenerative peritoneal dialysis system of claim 1, wherein fluid flow rate through the regeneration loop is greater than through the patient loop.

12. A regenerative peritoneal dialysis system comprising:

a dialysis fluid loop;

a filter located in the dialysis fluid loop, a first portion of the dialysis fluid sent to the filter rejected by the filter and returned upstream of the filter, a second portion of the dialysis fluid sent to the filter forming permeate, the permeate being rich in urea; and

a urea removing apparatus located in the dialysis fluid loop downstream from the filter to receive the permeate and absorb urea from the permeate.

13. The regenerative peritoneal dialysis system of claim 12, wherein the urea removing apparatus is one of:

a sorbent apparatus, a reverse osmosis apparatus and an electrooxidation apparatus.

14. The regenerative peritoneal dialysis system of claim 12, wherein the filter is a nanofilter.

15. The regenerative peritoneal dialysis system of claim 12, wherein the dialysis fluid loop is a regeneration loop placed in fluid communication with a patient loop for fluid communication with a patient.

16. The regenerative peritoneal dialysis system of claim 15, wherein the first portion of the dialysis fluid rejected by the filter is returned to a fluid communication junction between the regeneration loop and the patient loop.

17. A regenerative peritoneal dialysis system comprising:

a patient circuit;

a regeneration circuit;

a solution container fluidly connecting the patient circuit and the regeneration circuit such that fluids from the circuits are mixed directly; and

a urea removal apparatus located in the regeneration loop.

18. The regenerative peritoneal dialysis system of claim 17, wherein the urea removal apparatus includes a filter and a urea absorber, the filter permeating a urea rich fluid to the urea absorber.

19. The regenerative peritoneal dialysis system of claim 17, wherein the patient loop includes at least one of:

an activated charcoal medium, an anion exchanger and a filter located in the patient loop.

20. The regenerative peritoneal dialysis system of claim 17, wherein fluid flow rate through the regeneration loop is greater than through the patient loop.