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Stimuli-responsive systems for controlled drug delivery

  • US 8,357,400 B2
  • Filed: 11/21/2011
  • Issued: 01/22/2013
  • Est. Priority Date: 12/17/2002
  • Status: Active Grant
First Claim
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1. A material for delivery of insulin in response to glucose, comprising:

  • conjugates that include insulin covalently linked to a polymer, wherein the polymer includes two or more glucose analogs; and

    concanavalin A molecules that cross-link conjugates by non-covalently interacting with glucose analogs on different conjugates,wherein;

    the material is insoluble in the absence of glucose; and

    conjugates are released from the material in the presence of glucose at a rate that varies within physiological concentrations of glucose.

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