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Methods for detecting hepatocellular carcinoma

  • US 8,357,489 B2
  • Filed: 11/13/2009
  • Issued: 01/22/2013
  • Est. Priority Date: 11/13/2008
  • Status: Expired due to Fees
First Claim
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1. A method of distinguishing hepatocellular carcinoma (HCC) from viral induced cirrhosis in a subject, comprising:

  • a) measuring levels of at least three HCC markers selected from one or both of a first group (i) and a second group (ii) of markers in a biological sample from said subject to obtain a hepatocellular carcinoma marker profile from said subject;

    b) comparing said marker profile to a control profile obtained from a viral-induced cirrhosis control sample, wherein differential expression of the at least three HCC markers in said biological sample compared to the control sample indicates a diagnosis of hepatocellular carcinoma in said subject; and

    whereinc) said differential expression comprises decreased expression in said first group of HCC markers and increased expression in said second group of HCC markers, and whereind) said first group (i) consists of L-Selectin, IGFBP-6, IL-6sR, VCAM-1, FGF-basic, Fractalkine/CX3CL1, IL18; and

    e) said second group (ii) consists of β

    -Catenin, M-CSF, IL-8, MMP-10, Total p21, IL-1 ra, Resistin, interferon-gamma, BRAK/CXCL14, TNF-beta.

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