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Aerosolized fluoroquinolones and uses thereof

  • US 8,357,696 B2
  • Filed: 01/28/2010
  • Issued: 01/22/2013
  • Est. Priority Date: 05/18/2005
  • Status: Active Grant
First Claim
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1. A pharmaceutical aerosol for nasal, sinunasal or pulmonary administration comprising a dispersed liquid phase and a continuous gas phase, wherein the dispersed liquid phase:

  • (a) consists essentially of aqueous droplets comprising an active compound comprising a quinolone antibiotic, and at least one excipient comprising a multivalent metal ion;

    (b) has a mass median diameter from about 1 to about 5 μ

    m; and

    (c) has a droplet size distribution exhibiting a geometrical standard deviation less than or equal to about 3.0 μ

    m.

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