Optical analysis system for dynamic real-time detection and measurement
First Claim
Patent Images
1. A method of real-time processing and monitoring, comprising:
- blending a material of interest with a secondary material;
separating a source light into an illumination light and a calibration light;
illuminating the blended materials with the illumination light;
dividing light carrying information about the blended materials with a beam splitter into a first light portion and a second light portion, the first light portion and the second light portion having substantially similar characteristics;
after dividing the light with the beam splitter, directing the first light portion through at least one multivariate optical element to produce a first signal;
detecting the first signal at a first detector;
directing the second light portion in a direction of a second detector, the second detector configured to detect the second light portion;
detecting a portion of the calibration light at the first detector; and
determining, in real time, at least one selected property of at least one of the blended materials based upon a first detector output and a second detector output.
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Abstract
A method of real-time processing and monitoring comprises the steps of blending a material of interest (e.g., an active pharmaceutical material), with a secondary material, (e.g., an excipient), illuminating the blended materials with light, reflecting light carrying information about the blended materials through at least one multivariate optical element (148) and detecting said light with a first detector (152), detecting a deflected portion of the information carrying light with a second detector (156), and determining in real-time at least one selected property of the blended materials based on the detector outputs.
178 Citations
30 Claims
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1. A method of real-time processing and monitoring, comprising:
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blending a material of interest with a secondary material; separating a source light into an illumination light and a calibration light; illuminating the blended materials with the illumination light; dividing light carrying information about the blended materials with a beam splitter into a first light portion and a second light portion, the first light portion and the second light portion having substantially similar characteristics; after dividing the light with the beam splitter, directing the first light portion through at least one multivariate optical element to produce a first signal; detecting the first signal at a first detector; directing the second light portion in a direction of a second detector, the second detector configured to detect the second light portion; detecting a portion of the calibration light at the first detector; and determining, in real time, at least one selected property of at least one of the blended materials based upon a first detector output and a second detector output. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of real-time pharmaceutical processing and monitoring, comprising:
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blending a pharmaceutical powder by mixing an active agent with an excipient; separating a source light into a spectral-specific light and a calibration light; illuminating the pharmaceutical powder with the spectral-specific light through an optic window, the optic window configured to focus the spectral-specific light into the pharmaceutical powder; dividing light carrying information about the pharmaceutical powder with a beam splitter into a first light portion and a second light portion, the first light portion and the second light portion having substantially similar spectral characteristics; after dividing the light with the beam splitter, directing the first light portion through at least one multivariate optical element to produce a first signal; detecting the first signal at a first detector; detecting a portion of the calibration light at the first detector; directing the second light portion in a direction of a second detector, the second detector configured to detect the second light portion; and determining, in real time, at least one selected property of the pharmaceutical powder based upon a first detector output and a second detector output. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method of real-time pharmaceutical processing and monitoring, comprising:
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separating a source light into a spectral-specific light and a calibration light; illuminating a fluid in a container with the spectral-specific light through an optic window disposed proximate an aperture in a conduit in communication with the container; dividing light carrying information about the fluid with a beam splitter into a first light portion and a second light portion, the first light portion and the second light portion having substantially similar spectral characteristics; after dividing the light with the beam splitter, directing the first light portion through at least one multivariate optical element to produce a first signal; detecting the first signal at a first detector; detecting a portion of the calibration light at the first detector; directing the second light portion in a direction of a second detector, the second detector configured to detect the second light portion; and determining, in real time, at least one selected property of the fluid as the fluid flows past the optic window, based on a first detector output and a second detector output. - View Dependent Claims (21, 22, 23, 24, 25, 26)
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27. A method of real-time processing and monitoring, comprising:
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mixing a material of interest with a secondary material; separating a source light into an illumination light and a calibration light; illuminating the materials with the illumination light; dividing light carrying information about the materials with a beam splitter into a first light portion and a second light portion, the first light portion and the second light portion having substantially similar spectral characteristics; after dividing the light with a beam splitter, directing the first light portion through at least one multivariate optical element to produce a first signal; detecting the first signal at a first detector; detecting a portion of the calibration light at the first detector; directing the second light portion in a direction of a second detector, the second detector configured to detect the deflected portion; and determining, in real time, at least one selected property of at least one of the materials, based upon a first detector output and a second detector output. - View Dependent Claims (28, 29, 30)
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Specification