Apparatus and methods of compensating for organ deformation, registration of internal structures to images, and applications of same
First Claim
1. A method of surface registration in image guided surgery, comprising the steps of:
- a. preoperatively acquiring an image of an organ of interest of a living subject;
b. generating a first surface of the organ of interest of the living subject from the preoperatively acquired image;
c. designating a set of target points, T={tn}, n=1, 2, 3, . . . , NT, from the first surface of the organ of interest, wherein the set of target points T contains one or more patch points corresponding to homologous anatomical features of the first surface of the organ of interest, and wherein each of the set of target points tm is indexed with a binary index, pTm, such that when pTm=0, the target point tm is a non-patch point, and when pTm=1, the target point tm is a patch point, the one or more patch points of the target points define a particular salient anatomical feature of the first surface of the organ of interest;
d. intraoperatively acquiring an incomplete image of the organ of interest of the living subject;
e. generating a second surface of the organ of interest of the living subject from the intraoperatively acquired incomplete image, wherein the second surface is an incomplete surface of the organ of interest of the living subject;
f. designating a set of source points, S={sm}, m=1, 2, 3, . . . , NS, from the second surface of the organ of interest, wherein the set of source points S contain one or more patch points corresponding to homologous anatomical features of the second surface of the organ of interest, which is related to the corresponding homologous anatomical features of the first surface of the organ of interest, and wherein each of the set of source points sm is indexed with a binary index, pSm, such that when pSm=0, the source point sm is a non-patch point, and when pSm=1, the source point sm is a patch point, the one or more patch points of the source points define a particular salient anatomical feature of the second surface of the organ of interest;
g. determining a point correspondence between the set of source points S and the set of target points T, whereby a closest point operator, C={Cm} is determined;
h. biasing the point correspondence between the one or more source patch points and the one or more target patch points by a weighting factor, wPC, so as to assign weighted correspendence of a weighted point-based registration to the particular salient anatomical features and to bias the closest point operator Cm, via the following relationship;
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Accused Products
Abstract
A method and system of compensation for intra-operative organ shift of a living subject usable in image guide surgery. In one embodiment, the method includes the steps of generating a first geometric surface of the organ of the living subject from intra-operatively acquired images of the organ of the living subject, constructing an atlas of organ deformations of the living subject from pre-operatively acquired organ images from the pre-operatively acquired organ images, generating a second geometric surface of the organ from the atlas of organ deformations, aligning the second geometric surface of the organ to the first geometric surface of the organ of the living subject to determine at least one difference between a point of the first geometric surface and a corresponding point of the second geometric surface of the organ of the living subject, which is related to organ shift, and compensating for the intra-operative organ shift.
198 Citations
27 Claims
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1. A method of surface registration in image guided surgery, comprising the steps of:
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a. preoperatively acquiring an image of an organ of interest of a living subject; b. generating a first surface of the organ of interest of the living subject from the preoperatively acquired image; c. designating a set of target points, T={tn}, n=1, 2, 3, . . . , NT, from the first surface of the organ of interest, wherein the set of target points T contains one or more patch points corresponding to homologous anatomical features of the first surface of the organ of interest, and wherein each of the set of target points tm is indexed with a binary index, pTm, such that when pTm=0, the target point tm is a non-patch point, and when pTm=1, the target point tm is a patch point, the one or more patch points of the target points define a particular salient anatomical feature of the first surface of the organ of interest; d. intraoperatively acquiring an incomplete image of the organ of interest of the living subject; e. generating a second surface of the organ of interest of the living subject from the intraoperatively acquired incomplete image, wherein the second surface is an incomplete surface of the organ of interest of the living subject; f. designating a set of source points, S={sm}, m=1, 2, 3, . . . , NS, from the second surface of the organ of interest, wherein the set of source points S contain one or more patch points corresponding to homologous anatomical features of the second surface of the organ of interest, which is related to the corresponding homologous anatomical features of the first surface of the organ of interest, and wherein each of the set of source points sm is indexed with a binary index, pSm, such that when pSm=0, the source point sm is a non-patch point, and when pSm=1, the source point sm is a patch point, the one or more patch points of the source points define a particular salient anatomical feature of the second surface of the organ of interest; g. determining a point correspondence between the set of source points S and the set of target points T, whereby a closest point operator, C={Cm} is determined; h. biasing the point correspondence between the one or more source patch points and the one or more target patch points by a weighting factor, wPC, so as to assign weighted correspendence of a weighted point-based registration to the particular salient anatomical features and to bias the closest point operator Cm, via the following relationship; - View Dependent Claims (2, 3, 4, 5, 26)
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6. A method of surface registration in image guided surgery, comprising the steps of:
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a. pre-operatively acquiring an image of an anatomic structure of an organ of a living subject; b. generating a first surface of the anatomic structure of the organ from the preoperatively acquired image of the anatomic structure of the organ; c. constructing one or more first patches of the first surface of the anatomic structure, wherein each of the first patches contains a surface subset of physical space data related to a particular salient anatomical feature of the first surface of the anatomic structure, and assigning a weighted correspendence of a weighted point-based registration to the particular salient anatomical feature of each of the first patches; d. intra-operatively acquiring an incomplete image of the anatomic structure of the organ; e. generating a second surface of the anatomic structure of the organ from the intraoperatively acquired incomplete image of the anatomic structure of the organ, wherein the second surface is an incomplete surface of the anatomic structure of the organ; f. constructing one or more second patches of the second surface of the anatomic structure, wherein each second patch contains a surface subset of physical space data from the second surface related to a corresponding salient anatomical feature of the first surface of the anatomic structure; g. aligning the one or more second patches to the corresponding one or more first patches, wherein each second patch is dynamically biased to a corresponding first patch using the weighted point-based registration; and h. completing a registration of the second surface to the first surface with physical space data not contained in the first and second patches to indicate surgical position in both image space and physical space. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method of surface registration in image guided surgery, comprising the steps of:
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a. generating a first surface of an anatomic structure of an organ from pre-operatively acquired images of the anatomic structure of the organ; b. generating a second surface of the anatomic structure of the organ from intra-operatively acquired incomplete images of the anatomic structure of the organ, wherein the second surface is an incomplete surface of the anatomic structure of the organ; c. constructing one or more second patches corresponding to the second surface of the anatomic structure, wherein each second patch contains a surface subset of physical space data from the second surface related to a corresponding particular salient anatomical feature of the first surface of the anatomic structure, and assigning a weighted correspendence of a weighted point-based registration to the particular salient anatomical feature; d. aligning the one or more second patches to the corresponding one or more first patches, wherein each second patch is dynamically biased to a corresponding first patch using the weighted point-based registration; and e. completing a registration of the second surface to the first surface with physical space data not contained in the first and second patches to indicate surgical position in both image space and physical space. - View Dependent Claims (18, 19)
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20. A system of surface registration in image guided surgery, comprising:
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a. a first imaging acquiring device for pre-operatively acquiring images of an anatomic structure of an organ of a living subject; b. a second imaging acquiring device for intra-operatively acquiring incomplete images of the anatomic structure of the organ; and c. at least one computer coupled with the first image acquiring device and the second image acquiring device and adapted for performing the steps of; i). generating a first surface of the anatomic structure of the organ from the pre-operatively acquired images of the anatomic structure of the organ; ii). constructing one or more first patches of the first surface of the anatomic structure, wherein each of the first patchs contains a surface subset of physical space data related to a particular salient anatomical feature of the first surface of the anatomic structure, and assigning a weighted correspendence of a weighted point-based registration to the particular salient anatomical feature of each of the first patches; iii). generating a second surface of the anatomic structure of the organ from the intra-operatively acquired incomplete images of the anatomic structure of the organ, wherein the second surface is an incomplete surface of the anatomic structure of the organ; iv). constructing one or more second patches of the second surface of the anatomic structure, wherein each second patch contains a surface subset of physical space data from the second surface related to a corresponding salient anatomical feature of the first surface of the anatomic structure; v). aligning the one or more second patches to the corresponding one or more first patches, wherein each second patch is dynamically biased to a corresponding first patch using the weighted point-based registration; and vi). completing a registration of the second surface to the first surface with physical space data not contained in the first and second patches to indicate surgical position in both image space and physical space. - View Dependent Claims (21, 22, 23, 24, 25, 27)
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Specification