Extravascular arrhythmia induction

• US 8,359,094 B2
• Filed: 07/31/2008
• Issued: 01/22/2013
• Est. Priority Date: 07/31/2008
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Bonner, Matthew David, Kuehn, Kevin Patrick, Nikolski, Vladimir Pavlovich, Sullivan, Joseph L., Havel, William John
• Primary Examiner(s): Getzow, Scott
• Assistant Examiner(s): PATTON, AMANDA K
• Application Number:
  US12/183,486
• Publication Number:
  US 20100030288A1
• Time in Patent Office: 1,636 Days
• Field of Search: 607 4- 5, 607/9
• US Class Current: 607/5
• CPC Class Codes: A61N 1/046 Specially adapted for shock therapy, e.g. defibrillation
• CPC Class Codes: A61N 1/0492 Patch electrodes A61N1/0412, A61N1/0428 take precedence
• CPC Class Codes: A61N 1/0504 Subcutaneous electrodes
• CPC Class Codes: A61N 1/385 Devices for inducing an abnormal cardiac function, e.g. fibrillation
• CPC Class Codes: A61N 1/3943 for threshold determination
• CPC Class Codes: A61N 1/39622 Pacing therapy

Abstract

A cardiac arrhythmia may be induced by delivering a sequence of pulses to a patient via one or more extravascular electrodes. In one example, one or more pacing pulses may be delivered to a patient via an extravascular electrode and a shock pulse may be delivered to the patient the extravascular electrode. In some examples, the pacing pulses and the shock pulse may be generated with energy from a common energy storage module and without interim charging of the module. For example, the pacing and shock pulses may be generated as the energy storage module dissipates. In another example, a cardiac arrhythmia may be induced in a patient by delivering a burst of pulses to a patient via an extravascular electrode. In some cases, the burst of pulses may be generated with energy from a common energy storage module and without interim charging of the energy storage module.

Claims

1. A method comprising:

discharging an energy storage module to generate a cardiac pacing pulse;

delivering the pacing pulse to a patient via an extravascular electrode;

discharging the energy storage module further to generate a cardiac shock pulse; and

delivering the shock pulse to the patient via the extravascular electrode after a predetermined time period has elapsed since the delivery of the pacing pulse, wherein the shock pulse is configured to induce an arrhythmia in the heart of the patient, wherein the predetermined time period is between approximately 240 milliseconds and approximately 400 milliseconds.

2. The method of claim 1, wherein delivering the pacing pulse comprises delivering a sequence of pacing pulses, and wherein delivering the shock pulse comprises delivering the shock pulse after the predetermined time period has elapsed since the delivery of a last pacing pulse of the sequence.

3. The method of claim 2, wherein consecutive pacing pulses of the sequence of pacing pulses are separated by a time interval.

4. The method of claim 3, wherein the time interval is less than approximately 500 milliseconds.

5. The method of claim 2, wherein the sequence of pacing pulses comprises approximately 4 to approximately 8 pacing pulses.

6. The method of claim 2, wherein each of the pacing pulses comprises a respective amplitude and the amplitudes of the pacing pulses decrease with each successive pacing pulse of the sequence.

7. The method of claim 1, further comprising selecting the predetermined time period to approximately synchronize the delivery of the shock pulse to a vulnerability period of the heart.

8. The method of claim 7, wherein the vulnerability period of the heart corresponds to a T-wave of a cardiac cycle of the patient.

9. The method of claim 1, wherein a waveform of the shock pulse comprises at least one of a monophasic untruncated exponential waveform, a monophasic truncated exponential waveform, a biphasic truncated exponential waveform or a symmetric biphasic waveform.

10. The method of claim 1, further comprising delivering a defibrillation shock to the heart of the patient to terminate the arrhythmia.

11. The method of claim 10, further comprising discharging the energy storage module to generate the defibrillation shock.

12. The method of claim 11, further comprising prior to discharging the energy storage module to generate the defibrillation shock, charging the energy storage module.

13. The method of claim 1, wherein the extravascular electrode comprises as least one of at least one of an extrathoracic electrode, a subcutaneous electrode, a submuscular electrode, an epicardial electrode or an intramural electrode.

14. The method of claim 1, wherein the energy storage module comprises an energy storage module of at least one of an implantable cardiac device, an external defibrillator or an external programmer.

15. The method of claim 1, wherein discharging the energy storage module further to generate a cardiac shock pulse comprises discharging the energy storage module following the discharging of the energy storage module to generate the cardiac pacing pulse without interim charging of the energy storage module.

16. The method of claim 1, wherein delivering the pacing pulse to the patient via the extravascular electrode comprises delivering the pacing pulse to the patient via the extravascular electrode positioned on an epidermis of the patient.

17. The method of claim 1, wherein a first medical device comprises the energy storage and is coupled to the extravascular electrode, the method further comprising delivering a defibrillation shock to the patient via a second medical device separate from the first medical device.

18. The method of claim 1, wherein the cardiac pacing pulse comprises a first pulse width and the cardiac shock pulse comprises a second pulse width, the second pulse width being different than the first pulse width.

19. A method comprising:

discharging an energy storage module to generate a cardiac pacing pulse;

delivering the pacing pulse to a patient via an extravascular electrode;

discharging the energy storage module further to generate a cardiac shock pulse; and

delivering the shock pulse to the patient via the extravascular electrode after a predetermined time period has elapsed since the delivery of the pacing pulse, wherein the shock pulse is configured to induce an arrhythmia in the heart of the patient, wherein delivering the pacing pulse comprises delivering a sequence of pacing pulses, and wherein delivering the shock pulse comprises delivering the shock pulse after the predetermined time period has elapsed since the delivery of a last pacing pulse of the sequence, and wherein each of the pacing pulses comprises a respective pulse width and the pulse widths of the pacing pulses increase with each successive pacing pulse of the sequence.

20. A system comprising:

an extravascular electrode;

a therapy module comprising an energy storage module; and

a processor that controls the therapy module to discharge the energy storage module to generate a cardiac pacing pulse, deliver the pacing pulse to a patient via the extravascular electrode, discharge the energy storage module further to generate a cardiac shock pulse, and deliver the shock pulse to the patient via the extravascular electrode after a predetermined time period has elapsed since the delivery of the pacing pulse, wherein the shock pulse is configured to induce an arrhythmia in the heart of the patient, wherein the pacing pulse comprises a sequence of pacing pulses, and wherein the processor controls the therapy module to deliver the shock pulse after the predetermined time period has elapsed since the delivery of a last pacing pulse of the sequence, and wherein each of the pacing pulses comprises a respective pulse width and the pulse widths of the pacing pulses increase with each successive pacing pulse of the sequence.

21. The system of claim 20, wherein consecutive pacing pulses of the sequence of pacing pulses are separated by a time interval.

22. The system of claim 21, wherein the time interval is less than approximately 500 milliseconds.

23. The system of claim 20, wherein the predetermined time period is between approximately 240 milliseconds and approximately 400 milliseconds.

24. The system of claim 20, wherein the processor selects the predetermined time period to approximately synchronize the delivery of the shock pulse to a vulnerability period of the heart.

25. The system of claim 20, wherein a waveform of the shock pulse comprises at least one of a monophasic untruncated exponential waveform, a monophasic truncated exponential waveform, a biphasic truncated exponential waveform or a symmetric biphasic waveform.

26. The system of claim 20, wherein the extravascular electrode comprises as least one of an extrathoracic electrode, a subcutaneous electrode, a submuscular electrode, an epicardial electrode, or an intramural electrode.

27. The system of claim 20, wherein the energy storage module comprises an energy storage module of at least one of an implantable cardiac device, an external defibrillator, or an external programmer.

28. The system of claim 20, wherein the processor controls the therapy module to discharge the energy storage module to generate a defibrillation shock and deliver the defibrillation shock to the patient.

29. The system of claim 28, wherein the processor controls the therapy module to charge the energy storage module prior to generating the defibrillation shock.

30. The system of claim 20, wherein the extravascular electrode is configured to be positioned on the patient'"'"'s epidermis.

31. The system of claim 20, further comprising a first medical device comprising the therapy module and coupled to the extravascular electrode, the system further comprising a second device configured to deliver a defibrillation shock to the patient.

32. A system comprising:

an extravascular electrode;

a therapy module comprising an energy storage module; and

a processor that controls the therapy module to discharge the energy storage module to generate a cardiac pacing pulse, deliver the pacing pulse to a patient via the extravascular electrode, discharge the energy storage module further to generate a cardiac shock pulse, and deliver the shock pulse to the patient via the extravascular electrode after a predetermined time period has elapsed since the delivery of the pacing pulse, wherein the shock pulse is configured to induce an arrhythmia in the heart of the patient, wherein the pacing pulse comprises a sequence of pacing pulses, and wherein the processor controls the therapy module to deliver the shock pulse after the predetermined time period has elapsed since the delivery of a last pacing pulse of the sequence, and wherein each of the pacing pulses comprises a respective amplitude and the amplitudes of the pacing pulses decrease with each successive pacing pulse of the sequence.