Blood treatment device

• US 8,361,006 B2
• Filed: 05/20/2010
• Issued: 01/29/2013
• Est. Priority Date: 08/25/2003
• Status: Active Grant

• Current Assignee: Fresenius Medical Care Deutschland GmbH (Fresenius Medical Care AG)
• Original Assignee: Fresenius Medical Care Deutschland GmbH (Fresenius Medical Care AG)
• Inventors: Kraemer, Matthias
• Primary Examiner(s): Wiest, Philip R
• Application Number:
  US12/801,086
• Publication Number:
  US 20110077575A1
• Time in Patent Office: 985 Days
• Field of Search: 422 44- 48, 604 401- 616, 604 8- 10, 210/739, 210/746, 210/85, 210/86, 210/97, 210/143
• US Class Current: 604/6.09
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1607 before use, i.e. upstream of dialyser
• CPC Class Codes: A61M 1/1609 after use, i.e. downstream of dialyser
• CPC Class Codes: A61M 1/3406 Physical characteristics of the filtrate, e.g. urea
• CPC Class Codes: A61M 1/3609 Physical characteristics of the blood, e.g. haematocrit, urea
• CPC Class Codes: A61M 2205/50 with microprocessors or computers

Abstract

A blood treatment device has a blood purification element divided into two chambers by a semipermeable membrane. With the device, nonphysiological conditions of the patient, in particular critical potassium concentrations and withdrawal rates, can be better prevented during the blood treatment. The device'"'"'s analyzer unit determines on the basis of at least one sensor the concentration of a substance in the blood in the blood inlet line, the instantaneous transfer rate of this substance through the membrane, and the total quantity of this substance withdrawn during the treatment. The determined concentration is compared with a first admissible value range, the transfer rate is compared with a second admissible value range, and the quantity of the substance withdrawn is compared with a third value range. The device'"'"'s control unit can instruct the device such that the blood treatment device performs the blood treatment while maintaining all three admissible value ranges.

Claims

1. A blood treatment device comprising a blood purification element which is divided into two chambers by a semipermeable membrane, with a first chamber being part of a dialysis fluid circuit and a second chamber being part of an extracorporeal blood circuit,

a dialysis fluid inlet line which leads from a dialysis fluid processing unit to supply fresh dialysis fluid to at least one of the first chamber and directly into the blood circuit,

a dialysis fluid outlet line for removing spent dialysis fluid from the first chamber,

a blood inlet line for supplying blood to the second chamber,

a blood return line for returning blood from the second chamber,

a control unit for controlling the blood treatment device,

an analyzer unit which is connected to the control unit, and

at least one sensor which is connected to the analyzer unit on at least one of the blood circuit and the dialysis fluid circuit for detecting the concentration of a substance which is capable of penetrating through the semipermeable membrane,

the analyzer unit being configured (i) to determine on the basis of detected values of the at least one sensor the concentration Cbi of the substance in the blood in the blood inlet line, the instantaneous transfer rate Δ

M/Δ

t of the substance through the membrane, and the total quantity M of the substance withdrawn through the membrane during the treatment, (ii) to store a first admissible value range for the blood concentration Cbi of the substance, a second admissible value range for the transfer rate Δ

M/Δ

t, and a third admissible value range for the total quantity M of the substance to be withdrawn, and (iii) to instruct the control unit such that the blood treatment device performs the blood treatment while maintaining all three of the admissible value ranges,

the dialysis fluid processing unit being configured to add potassium to the fresh dialysis fluid, and

the substance whose concentration is detected by the at least one sensor being potassium.

2. The blood treatment device according to claim 1, wherein the at least one sensor is provided in the dialysis fluid outlet line for determining a concentration Cdo.

3. The blood treatment device according to claim 2, wherein a second sensor is provided in the dialysis fluid inlet line for determining a concentration Cdi of the potassium and is connected to the analyzer unit.

4. The blood treatment device according to claim 2, wherein a concentration Cdi of the potassium in the dialysis fluid inlet line is predetermined by at least one of the control unit and the analyzer unit.

5. The blood treatment device according to claim 1, wherein the second value range extends from zero up to a maximum value.

6. The blood treatment device according to claim 1, wherein a target value Mend which is within the third value range is stored in the analyzer unit for the total quantity of the potassium to be withdrawn.

7. The blood treatment device according to claim 6, wherein the analyzer unit instructs the control unit that the target value Mend has been reached after a planned treatment time.

8. The blood treatment device according to claim 6, wherein the analyzer unit instructs the control unit that on reaching the target value Mend the blood treatment is to be continued with a concentration Cdi of the potassium in the dialysis fluid inlet line such that there is no longer any transfer of the potassium through the membrane.

9. The blood treatment device according to claim 1, wherein the control unit is configured for ordering an initial measurement of the blood concentration Cbi with preset treatment parameters and the analyzer unit is configured for determining an initial value of Cbi, and based on the initial value of Cbi, the first admissible value range and the second admissible value range for the blood treatment, proposing a value for at least one of a concentration Cdi of the potassium in the dialysis fluid inlet line, and a dialysis fluid flow Qd and a blood flow Qb.

10. The blood treatment device according to claim 9, wherein the analyzer unit determines the concentration Cdi based on the value which corresponds to a lower limit of the first admissible value range.

11. The blood treatment device according to claim 10, wherein a selection device for prioritizing the withdrawal of the potassium is provided on an input unit by an alignment with the lower limit of the first admissible value range or the upper limit of the second admissible value range.

12. The blood treatment device according to claim 9, wherein the analyzer unit determines the concentration Cdi by an upper limit of the second admissible value range.