Apparatus and methods for containing and delivering therapeutic agents

• US 8,361,054 B2
• Filed: 12/08/2009
• Issued: 01/29/2013
• Est. Priority Date: 12/23/2008
• Status: Active Grant

• Current Assignee: Cook Medical Incorporated (Cook Group Incorporated)
• Original Assignee: Cook Medical Incorporated (Cook Group Incorporated)
• Inventors: Ducharme, Richard W., Sugg, David E.
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): Anderson, Michael J
• Application Number:
  US12/633,027
• Publication Number:
  US 20100160897A1
• Time in Patent Office: 1,148 Days
• Field of Search: 604/58, 604/82, 604/508, 604/118, 604/70, 604/24, 604/83, 604/85
• US Class Current: 604/508
• CPC Class Codes: A61B 1/018 for receiving instruments
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61M 13/003 Blowing gases other than for carrying powders, e.g. for inflating, dilating or rinsing
• CPC Class Codes: A61M 16/0477 with incorporated means for delivering or removing fluids
• CPC Class Codes: A61M 2005/006 for gases, e.g. CO2
• CPC Class Codes: A61M 2025/0089 Single injection needle protruding axially, i.e. along the longitudinal axis of the catheter, from the distal tip
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/8225 using incorporated gas cartridges for the driving gas
• CPC Class Codes: A61M 2206/11 Laminar flow
• CPC Class Codes: A61M 2206/14 Static flow deviators in tubes disturbing laminar flow in tubes, e.g. archimedes screws
• CPC Class Codes: A61M 5/1409 in series, e.g. first substance passing through container holding second substance, e.g. reconstitution systems needle sets A61M5/162
• CPC Class Codes: A61M 5/155 pressurised by gas introduced into the reservoir
• CPC Class Codes: B01F 33/5011 portable during use, e.g. hand-held

Abstract

The present embodiments provide apparatus and methods suitable for containing and delivering a therapeutic agent to a target site. The apparatus generally comprises at least one container for holding a therapeutic agent, and a pressure source for facilitating delivery of the therapeutic agent. In one embodiment, the pressure source may be placed in selective fluid communication with a proximal region of the container and fluid from the pressure source may flow through at least a portion of the container to urge the therapeutic agent through the container towards the target site. In an alternative embodiment, the pressure source may be selectively in fluid communication with either a first hollow tube and the container so that therapeutic agent is urged into a catheter, or with a second hollow tube and a catheter so that a fluid from the pressure source bypasses the container and enters the catheter.

Claims

1. Apparatus suitable for facilitating delivery of a therapeutic agent, the apparatus comprising:

a pressure source;

a container having proximal and distal ends with an inlet port at the proximal end for receiving a fluid from the pressure source;

a therapeutic agent disposed within the container;

a tube member having proximal and distal ends, the proximal end of the tube member positioned within the container; and

a flow obstruction member positioned within the container between the inlet port and the proximal end of the tube member, the flow obstruction member structured to direct fluid around the flow obstruction member and towards the proximal end of the tube member, the flow obstruction member and the tube member being spaced relative to each other to cause the fluid to flow around the obstruction member and draw the therapeutic agent into the tube member and direct the therapeutic agent distally therethrough.

2. The apparatus of claim 1 further comprising at least one sealing member located at the proximal end and at least one sealing member located at the distal end of the container.

3. The apparatus of claim 1 further comprising:

a switch located at the proximal end and a switch located at the distal end of the container;

an opening located in the interior of each switch;

the switches having a first position wherein the openings are not in fluid communication with the proximal and distal ends of the container; and

the switches having a second position wherein the switches are in fluid communication the proximal and distal ends of the container.

4. The apparatus of claim 1 wherein the flow obstruction member comprises a sphere shape.

5. The apparatus of claim 1 wherein the flow obstruction member comprises a tear drop shape oriented with the rounded end facing the inlet port.

6. The apparatus of claim 1 further comprising a support structure connected to the container and having a support member projecting radially inwardly and connected to the flow obstruction member via a support member.

7. The apparatus of claim 6 wherein a plug maintains the tube member in about the radial center of the container.

8. The apparatus of claim 1 wherein the container has an outer diameter ranging from about 0.90 inches to about 1.10 inches, the flow obstruction member has a diameter ranging from about 0.25 inches to about 0.35 inches, the tube member has an inner diameter ranging from about 0.19 to about 0.22 inches, and a distance between the flow obstruction member and the tube member ranging from about 0.25 mm to about 0.35 mm.

9. The apparatus of claim 1 wherein the fluid and the therapeutic agent are mixed together within the tube member to form a mixture, the mixture having a generally uniform dispersion of the therapeutic agent within the fluid.

10. The apparatus of claim 1 wherein the fluid and the therapeutic agent are mixed together within the tube member to form a mixture, the mixture having a consistent volumetric flow rate of therapeutic agent.