Methods for forming dyed microspheres and populations of dyed microspheres
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Abstract
Various methods for forming dyed microspheres are provided. One method includes activating a chemical structure coupled to a dye using heat or light to form a reaction intermediate in the presence of a microsphere. The reaction intermediate covalently attaches to a polymer of the microsphere thereby coupling the dye to the polymer and forming the dyed microsphere. Additional methods are provided for forming a dyed microsphere coupled to a molecule. These methods include dyeing the microspheres as described above in addition to synthesizing the molecule on an outer surface of the dyed microspheres. A population of dyed microspheres is also provided. Each of the dyed microspheres of the population includes a dye attached to a polymer of each of the dyed microspheres by a chemical structure. A coefficient of variation in dye characteristics of the population of dyed microspheres attributable to the dye is less than about 10%.
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15 Claims
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1. A compound having the formula:
- 2. A composition comprising 1,5-ethyl-di-amino-naphthalene-sulfonic azide attached to a dye.
- 4. A population of dyed microspheres, wherein each of the dyed microspheres of the population comprises a dye attached to a polymer of each of the dyed microspheres by a chemical structure in the interior of each of the dyed microspheres, and wherein a coefficient of variation in dye characteristics of the population of dyed microspheres attributable to the dye is less than about 10% and wherein the chemical structure comprises 1,5-ethyl-di-amino-napthalene-sulfonic azide.
Specification