Preparation of antimicrobial contact lenses with reduced haze using swelling agents

• US 8,361,355 B2
• Filed: 01/20/2011
• Issued: 01/29/2013
• Est. Priority Date: 03/30/2007
• Status: Active Grant

• Current Assignee: Johnson & Johnson Vision Care Incorporated (Johnson & Johnson)
• Original Assignee: Johnson & Johnson Vision Care Incorporated (Johnson & Johnson)
• Inventors: Li, Yongcheng, Beaton, Stephen R.
• Primary Examiner(s): Del Sole, Joseph
• Assistant Examiner(s): OCHYLSKI, RYAN M
• Application Number:
  US13/010,117
• Publication Number:
  US 20110111120A1
• Time in Patent Office: 740 Days
• Field of Search: 264/2.6, 264/343
• US Class Current: 264/2.6
• CPC Class Codes: A61L 12/088 Heavy metals
• CPC Class Codes: A61L 2300/102 Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/106 Halogens or compounds thereof, e.g. iodine, chlorite
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: G02B 1/043 Contact lenses

Abstract

This invention relates to antimicrobial lenses containing metals and methods for their production.

Claims

1. A method of preparing an antimicrobial lens comprising a metal salt, wherein said method comprises the steps of

(a) treating a cured lens, with a solution comprising salt precursor and a swelling agent,

(b) treating the lens of step (a) after removing it from the solution of step (a) with a solution comprising a swelling agent for an appropriate period of time of about 10 to about 30 seconds, and

(c) treating the lens of step (b) after removing it from the solution of step (b) with a solution comprising a metal agent and a swelling agent wherein the swelling agents used in each step can be the same or different from the swelling agent used in each other step.

2. The method of claim 1 wherein at least one of the swelling agents is selected from the group consisting of ethylene glycol-n-butyl ether, diethylene glycol-n-butyl ether, diethylene glycol methyl ether, ethylene glycol phenyl ether, propylene glycol methyl ether, dipropylene glycol methyl ether, tripropylene glycol methyl ether, propylene glycol methyl ether acetate, dipropylene glycol methyl ether acetate, propylene glycol-n-propyl ether, dipropylene glycol-n-propyl ether, tripropylene glycol-n-butyl ether, propylene glycol-n-butyl ether, dipropylene glycol-n-butyl ether, tripropylene glycol-n-butyl ether, tripropylene glycol-n-propyl ether, proplyene glycol phenyl ether, dipropylene glycol dimethyl ether, butyl acetate, dipropylene glycol methyl ether acetate, and dipropylene dimethyl ether.

3. The method of claim 1 wherein at least one of the swelling agents is aqueous isopropanol, or aqueous propylene glycol.

4. The method of claim 1 wherein at least one of the swelling agents is about 30% to about 70% aqueous isopropanol.

5. The method of claim 1 wherein at least one of the swelling agents is 50% aqueous isopropanol.

6. The method of claim 1 wherein at least one of the swelling agents is aqueous propylene glycol.

7. The method of claim 1 wherein the salt precursor is selected from the group consisting sodium chloride, sodium iodide, sodium bromide, sodium sulfide, lithium chloride, lithium iodide, lithium bromide, lithium sulfide, potassium bromide, potassium chloride, potassium sulfide, potassium iodide, rubidium iodide, rubidium bromide, rubidium chloride, rubidium sulfide, caesium iodide, caesium bromide, caesium chloride, caesium sulfide, francium iodide, francium bromide, francium chloride, francium sulfide, and sodium tetrachloro argentate.

8. The method of claim 1 wherein the salt precursor is sodium iodide.

9. The method of claim 1 wherein the metal agent is selected from the group consisting of silver nitrate, silver triflate, or silver acetate, silver sulfate, silver tetrafluoroborate, silver sulfate, zinc acetate, zinc sulfate, copper acetate, and copper sulfate.

10. The method of claim 1 wherein the metal agent is silver nitrate.

11. The method of claim 1 wherein the appropriate time is about 10 to about 20 seconds.

12. The method of claim 1 wherein the appropriate time is about 20 to about 30 seconds.

13. The method of claim 1 wherein one or more of the solutions of steps (a), (b), and (c) comprise a dispersing agent.

14. The method of claim 13, wherein the dispersing agent is selected from the group consisting of polyvinylpyrrolidone, polyvinylalcohol and derivatives, glycerine, polyethylene oxide, poly(dimethyl acrylamide), poly(N-vinyl-N-methylacetamide), cysteine, methionine, sodium sulfide, sodium thiosulfate, and sodium thiocyanate.

15. The method of claim 13 wherein the dispersing agent is polyvinylpyrrolidone K90.