Monitoring methods and apparatus

• US 8,361,389 B2
• Filed: 11/22/2011
• Issued: 01/29/2013
• Est. Priority Date: 12/18/2003
• Status: Active Grant

• Current Assignee: Inverness Medical Switzerland GmbH (Abbott Laboratories)
• Original Assignee: Inverness Medical Switzerland GmbH (Abbott Laboratories)
• Inventors: Sheard, Paul, Reay, Marika
• Primary Examiner(s): Menon, Krishnan S
• Assistant Examiner(s): Gerido, Dwan A
• Application Number:
  US13/302,020
• Publication Number:
  US 20120064613A1
• Time in Patent Office: 434 Days
• Field of Search: 422/68.1, 422/69, 422/81, 422/50, 436/43
• US Class Current: 422/68.1
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: G01N 2333/58 Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Brain natriuretic peptide [BNP, proBNP]; Cardionatrin; Cardiodilatin
• CPC Class Codes: G01N 2800/32 Cardiovascular disorders
• CPC Class Codes: G01N 33/5302 Apparatus specially adapted for immunological test procedures
• CPC Class Codes: G16H 40/67 for remote operation
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment
• CPC Class Codes: Y10T 436/11 Automated chemical analysis

Abstract

A device for remote management of patients suffering from heart failure and hypertension can measure one or more biomarker. The device aids in monitoring the efficacy and safety of treatment in such patients.

Claims

1. A device for testing and recording the levels of one or more biomarkers that provide information about a patient'"'"'s health, the device comprising:

a testing cartridge configured to measure, in a sample taken from a patient, a level of a brain natriuretic peptide (BNP), and a level of a marker of renal function;

a memory capable of storing the results of the measurement of the level of BNP and the marker of renal function;

a detector for providing a test result of the measured BNP and marker of renal function;

a display for presenting information to the patient;

an input region to enable a patient to input data in response to information presented on the display; and

a communication port configured to communicate the measured level of BNP, the measured level of the marker of renal function, data input by the patient, or a combination thereof, to a health care provider,

wherein the device can be configured to provide instructions to the patient to seek medical care if the levels of at least one of the measured BNP and marker of renal function exceeds a predetermined threshold or if the patient indicates that acute symptoms are present; and

wherein the device is personalized for the patient based on age, gender, body mass or disease status of the patient.

2. The device of claim 1, wherein the marker of renal function includes creatinine or Cystatin C.

3. The device of claim 1, wherein the BNP includes active BNP and an inactive BNP (N-BNP).

4. The device of claim 1, wherein the device is configured to compare the result of a measurement of the level of BNP to a stored result.

5. The device of claim 4, wherein the memory is further capable of storing a threshold value of the level of the BNP.

6. The device of claim 5, wherein the device is configured to compare the result of a measurement of the level of the BNP to the threshold value.

7. The device of claim 6, wherein the device is configured to instruct the patient to alter a treatment plan when the level of the BNP exceeds the threshold value.

8. The device of claim 6, wherein the communication port is further configured to receive information from the health care provider.