Composition comprising sarsasapogenin

• US 8,361,516 B2
• Filed: 07/31/2007
• Issued: 01/29/2013
• Est. Priority Date: 08/03/2006
• Status: Active Grant

• Current Assignee: Sederma, Co.
• Original Assignee: Sederma, Co.
• Inventors: Lintner, Karl, Mas Chamberlin, Claire
• Primary Examiner(s): Leith, Patricia
• Assistant Examiner(s): WINSTON, RANDALL O
• Application Number:
  US12/309,910
• Publication Number:
  US 20090253666A1
• Time in Patent Office: 2,009 Days
• Field of Search: None
• US Class Current: 424/725
• CPC Class Codes: A61K 2800/70 Biological properties of the composition as a whole
• CPC Class Codes: A61K 8/63 Steroids; Derivatives thereof
• CPC Class Codes: A61K 8/9728 Fungi, e.g. yeasts
• CPC Class Codes: A61K 8/9789 Magnoliopsida [dicotyledons]
• CPC Class Codes: A61K 8/9794 Liliopsida [monocotyledons]
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/002 Aftershave preparations
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations
• CPC Class Codes: A61Q 19/10 Washing or bathing preparations
• CPC Class Codes: A61Q 5/02 Preparations for cleaning the hair
• CPC Class Codes: A61Q 9/02 Shaving preparations

Abstract

The présent invention relates to a composition comprising sarsasapogenin or a plant extract containing it in order to improve the gêneral state of the skin and in particular to improve and/or embellish any part of the body showing a déficit in lipids. More particularly, the invention is directed to a cosmetic method to improve the figure, comprising the step of topically applying to the skin a cosmetic or dermopharmaceutical composition comprising sarsasapogenin to favour the expansion and/or the formation of the subcutaneous adipose tissue, and/or to favour the lipid synthesis in the epidermis.

Claims

1. A method of cosmetic lipofilling comprising applying to skin of a subject in need thereof a composition comprising sarsasapogenin in an amount sufficient to stimulate the expansion or formation of subcutaneous adipose tissue, and wherein the skin to which said composition is applied is deficient in subcutaneous adipose tissue.

2. The method of claim 1, wherein the expansion or formation of subcutaneous adipose tissue and cosmetic lipofilling is by means of adipogenesis, adipocytic differentiation, lipogenesis and/or lipid synthesis.

3. The method of claim 1, wherein the sarsasapogenin is present in an amount from about 0.000001% w/w to about 20% w/w of the composition.

4. The method of claim 1, wherein the sarsasapogenin is produced by chemical synthesis, enzymatic synthesis, or by plant extraction.

5. The method of claim 4, wherein the sarsasapogenin is extracted from a plant selected from the group consisting of Agave sisalana, Agave americana, Asparagus, A. officinalis, A. adscende, A. racemosus, Radix Asparagi, Tian-Dong, A. cochichinensis (lour.) Merr., A. cochichinensis (lour.) Merr. Var. gaudichaudianus, A. taliensis, A. munitus, A. myriacanthus, A. meioclados Levl, A. trichoclados, A. filicinus, Yucca, Yucca spp, Y. filifera, Y. filamentosa, Y.baccata, Y. brevifolia Y. schidigera, Shatavari, Smilax, Sarsaparilla, Salsepareille, Sarsaparriha, khao yen, Saparna, jupicanga, smilace, China root, Smilax Aristolochiaefolia, Smilax ornata, Trigonella foenum graecum, fenugrec, Diascoré

es, Dioscorea colettii, Lilium brownii, Quillaja saponaria, Solanum paniculatum, Lycopersicon pimpinellifolium, Tribulus terrestris, Nicotianum tabacum, Radix sarsaparilla, Anemarrhena asphodeloides, Anemarrhena asphodeloides bunge, and zhi mu.

6. The method of claim 5, wherein the sarsasapogenin is extracted from Anemarrhena asphodeloides bunge.

7. The method of claim 1, wherein the composition further comprises at least one complementary active selected from the group consisting of an active ingredient stimulating lipogenesis, an active ingredient stimulating adipogenesis, a strengthening active ingredient, an active ingredient acting on skin'"'"'s tonicity, an active ingredient having curving effects, a vasodilatator active ingredient, and an active ingredient favouring microcirculation.

8. The method of claim 1, wherein the composition is in a cosmetic form selected from the group consisting of a cream, lotion, ointment, milk, gel, emulsion, dispersion, solution, suspension, cleanser, foundation, anhydrous preparation, lipstick, body oil, bath oil, shower gel, bath gel, shampoo, scalp treatment lotion, sun-screen lotion, artificial suntan lotion, shaving cream, shaving foam, aftershave lotion, make-up, skin “

essence,”

serum, adhesive material, absorbent material, transdermal patch, and a powder.

9. The method of claim 1, wherein the composition is applied to the skin in an area selected from the group consisting of bust, low neckline, buttocks, face, lips, cheeks, eyelids, and hands.

10. The method of claim 3, wherein the sarsasapogenin is present in an amount from about 0.00001% w/w to 1% w/w of the composition.

11. The method of claim 10, wherein the sarsasapogenin is present in an amount from about 0.0001% to 0.1% w/w of the composition.

12. The method of claim 7, wherein the complementary active is selected from the group consisting of hops extracts, kigelia africana, sage, soya, sa bal serrulata, damiana, de dong quai, dandelion, cumin, liquorice, cnicus benedictus, red elm, raspberry bush, lupin, fennel, pepper, malt, mourere, Kombucha, clover, and alchemille.

13. A method of increasing adipocytic mass in subcutaneous adipose tissue in a subject desiring cosmetic lipofilling comprising applying to skin of the subject a topical composition comprising a dermatologically acceptable carrier and sarsasapogenin in an amount from about 0.000001% w/w to about 20% w/w of the composition, and wherein the composition is in a cosmetic form selected from the group consisting of a cream, lotion, ointment, milk, gel, emulsion, dispersion, solution, suspension, cleanser, foundation, anhydrous preparation, lipstick, body oil, bath oil, shower gel, bath gel, shampoo, scalp treatment lotion, sun-screen lotion, artificial suntan lotion, shaving cream, shaving foam, aftershave lotion, make-up, skin “

essence”

, serum, adhesive material, absorbent material, transdermal patch, and a powder.