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Expandable medical device with beneficial agent concentration gradient

  • US 8,361,537 B2
  • Filed: 10/26/2007
  • Issued: 01/29/2013
  • Est. Priority Date: 03/30/1998
  • Status: Expired due to Fees
First Claim
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1. A method of forming an implantable medical device configured to release at least one therapeutic agent therefrom, wherein the therapeutic agent is disposed in a matrix affixed to the body of the implantable medical device, the body includes at least one recess, and wherein the concentration of the at least one therapeutic agent in the matrix varies as a continuous gradient relative to a surface of the body of the implantable medical device, the method comprising:

  • forming a first homogeneous solution comprising an amount of the at least one therapeutic agent mixed with a polymeric binder;

    introducing the first homogeneous solution into the at least one recess in the body of the implantable medical device;

    solidifying the first homogeneous solution, thereby forming a first portion of the matrix;

    forming a second homogeneous solution comprising an amount of the at least one therapeutic agent mixed with the polymeric binder;

    applying the second homogeneous solution to the first portion of the matrix, thereby at least partially liquefying the first portion of the matrix; and

    solidifying the second homogeneous solution, thereby forming a second portion of the matrix, wherein the concentration of the at least one therapeutic agent in the matrix is different in the first and second portions of the matrix.

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