Methods for applying an application material to an implantable device

• US 8,361,538 B2
• Filed: 12/09/2008
• Issued: 01/29/2013
• Est. Priority Date: 12/19/2007
• Status: Expired due to Fees

• Current Assignee: Abbott Laboratories
• Original Assignee: Abbott Laboratories
• Inventors: Pacetti, Stephen
• Primary Examiner(s): SANDERS, KRIELLION ANTIONETTE
• Application Number:
  US12/331,290
• Publication Number:
  US 20090181159A1
• Time in Patent Office: 1,512 Days
• Field of Search: 427/2.31, 427/2.24
• US Class Current: 427/2.24
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 2300/42 Anti-thrombotic agents, anticoagulants, anti-platelet agents
• CPC Class Codes: A61L 2420/02 Methods for coating medical devices
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: B05B 13/0228 the movement of the objects being rotative B05B13/0242 takes precedence
• CPC Class Codes: B05B 17/06 using ultrasonic or other kinds of vibrations
• CPC Class Codes: B05B 5/087 Arrangements of electrodes, e.g. of charging, shielding, collecting electrodes B05B5/12, B05B5/14 take precedence; arrangements of electrodes on the discharge apparatus B05B5/0533
• CPC Class Codes: B05D 1/04 involving the use of an electrostatic field B05D1/025 and B05D1/14 take precedence

Abstract

Devices and methods for applying a coating to an implantable device are disclosed. A method for applying a coating to an implantable device is disclosed. The method includes positioning an implantable device relative to an ultrasonic material delivery apparatus. The ultrasonic material delivery apparatus includes an ultrasonic generator. At least one of the ultrasonic material delivery apparatus and the implantable device has a positive or negative electric charge. An application material is applied to the implantable device using the ultrasonic material delivery apparatus.

Claims

1. A method for applying a coating to an implantable device, comprising:

positioning an implantable device relative to an ultrasonic material delivery apparatus, the ultrasonic material delivery apparatus being configured to deliver a liquid application material to the implantable device, the ultrasonic material delivery apparatus including an ultrasonic generator, a nozzle body, and an ultrasonic horn;

applying a charge to both the implantable device and the liquid application material, the implantable device having a charge opposite to that of the application material; and

applying the liquid application material to the implantable device using the ultrasonic material delivery apparatus to coat the implantable device.

2. The method of claim 1, further comprising during application of the material to the implantable device applying a voltage potential to the ultrasonic material delivery apparatus to give the ultrasonic material delivery apparatus one of:

a positive electric charge or negative electric charge.

3. The method of claim 2, wherein the material delivery device is selectively electrically isolated from the ultrasonic generator.

4. The method of claim 2, wherein the material delivery apparatus combines ultrasonic atomization with a flowing gas stream.

5. The method of claim 1, wherein the ultrasonic material delivery apparatus has a positive or negative electric charge and the positive or negative electric charge is of sufficient strength to assist with atomization of the application material.

6. The method of claim 1, further comprising positioning the implantable device between the ultrasonic material delivery apparatus and a conductive member.

7. The method of claim 6, wherein the conductive member either has a positive or a negative charge or is grounded.

8. The method of claim 1, further comprising positioning a conductive member between the implantable device and the ultrasonic material delivery apparatus.

9. The method of claim 8, wherein the conductive member either has a positive or a negative charge or is grounded.

10. The method of claim 1, wherein the implantable device, the ultrasonic material delivery apparatus, or the conductive member have a difference in electrical potential of less than or equal to about 100 kV in either a positive or negative polarity.

11. The method of claim 1, wherein both the implantable device and the ultrasonic material delivery apparatus have either a positive or a negative charge.

12. The method of claim 1, wherein the application material includes a radiopaque material.

13. The method of claim 1, wherein the application material includes at least one bioactive agent that is an anti-proliferative, anti-inflammatory, antineoplastic, antiplatelet, anti-coagulant, anti-fibrin, antithrombonic, antimitotic, antibiotic, antiallergic or antioxidant drug.

14. The method of claim 1, wherein the application material includes a durable or biodegradable polymer.

15. The method of claim 1, wherein the application material includes a solvent.

16. The method of claim 1, wherein the implantable device is a closure element.

17. The method of claim 1, wherein the implantable device is a stent.

18. The method of claim 2, further comprising at least one of the material delivery device and the implantable device being grounded.

19. A method for applying a coating to an implantable device, the method comprising:

positioning an implantable device between a conductive member and an ultrasonic material delivery apparatus, the ultrasonic material delivery apparatus being configured to deliver a liquid application material to the implantable device, the ultrasonic material delivery apparatus including an ultrasonic generator, a nozzle body, and an ultrasonic horn and the conductive member either having a positive or a negative charge; and

applying a charge to the liquid application material, the conductive member having a charge opposite to that of the liquid application material; and

applying the liquid application material to the implantable device using the ultrasonic material delivery apparatus to coat the implantable device.

20. The method of claim 19, further comprising at least one of the ultrasonic material delivery apparatus and the implantable device being grounded.

21. The method of claim 19, wherein the application material includes a radiopaque material.

22. The method of claim 19, wherein the application material includes at least one bioactive agent that is an anti-proliferative, anti-inflammatory, antineoplastic, antiplatelet, anti-coagulant, anti-fibrin, antithrombonic, antimitotic, antibiotic, antiallergic or antioxidant drug.

23. A method for applying a coating to a stent, the method comprising:

positioning a stent between an ultrasonic material delivery apparatus and a grounded conductive member, the ultrasonic material delivery apparatus being configured to deliver a liquid application material to the implantable device, the ultrasonic material delivery apparatus including an ultrasonic generator, a nozzle body, and an ultrasonic horn, at least one of the ultrasonic material delivery apparatus and the stent having a positive or negative electric charge;

applying ultrasonic energy to an application material using the ultrasonic generator;

applying a charge to both the stent and the liquid application material, the stent having a charge opposite to that of the liquid application material; and

applying the liquid application material to the stent using the ultrasonic material delivery apparatus to coat the stent.

24. The method of claim 23, wherein the applied ultrasonic energy is sufficient to facilitate atomization of the application material.

25. The method of claim 23, wherein the stent has a positive or negative electric charge and the positive or negative electric charge is of sufficient strength to facilitate atomization of the application material.

26. A method for applying a coating to an implantable device, the method comprising:

positioning a conductive member between an implantable device and an ultrasonic material delivery apparatus, the ultrasonic material delivery apparatus being configured to deliver a liquid application material to the implantable device, the ultrasonic material delivery apparatus including an ultrasonic generator, a nozzle body, and an ultrasonic horn, and the conductive member either having a positive or a negative charge; and

applying a charge to the liquid application material, the conductive member having a charge opposite to that of the liquid application material; and

applying the application material to the implantable device using the ultrasonic material delivery apparatus to coat the implantable device.

27. The method of claim 26, further comprising at least one of the ultrasonic material delivery apparatus and the implantable device being grounded.

28. The method of claim 26, wherein the application material includes a radiopaque material.

29. The method of claim 26, wherein the application material includes at least one bioactive agent that is an anti-proliferative, anti-inflammatory, antineoplastic, antiplatelet, anti-coagulant, anti-fibrin, antithrombonic, antimitotic, antibiotic, antiallergic or antioxidant drug.