Imaging methods and compositions comprising fluorescent dyes associated with viral components for nerve imaging
First Claim
Patent Images
1. A composition comprising:
- a fluorescent dye; and
a neurotropic herpes varicellae unable to replicate in nerve cells,wherein the fluorescent dye is bound to the virus to form a complex that is capable of penetrating nerve cells.
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Abstract
Disclosed herein are compositions and methods for imaging nerve cells. The composition comprises a fluorescent dye; and a viral component selected from a neurotropic, replication-defective virus, a viral protein of a neurotropic virus, and a capsid of a neurotropic virus. Although the fluorescent dye in itself cannot penetrate nerve cells, the fluorescent dye is bound to the viral component to form a dye/viral component complex that is capable of penetrating nerve cells.
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Citations
3 Claims
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1. A composition comprising:
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a fluorescent dye; and a neurotropic herpes varicellae unable to replicate in nerve cells, wherein the fluorescent dye is bound to the virus to form a complex that is capable of penetrating nerve cells. - View Dependent Claims (2, 3)
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Specification