Ascorbic acid esters of resveratrol and cosmetic compositions

• US 8,362,076 B2
• Filed: 11/11/2011
• Issued: 01/29/2013
• Est. Priority Date: 07/31/2007
• Status: Active Grant

• Current Assignee: ELC Management LLC (The Estee Lauder Companies Inc.)
• Original Assignee: ELC Management LLC (The Estee Lauder Companies Inc.)
• Inventors: Maes, Daniel H., Mohammadi, Fatemeh, Qu, Lisa, Czarnota, Anna, Mammone, Thomas, Declercq, Lieve, Zecchino, Julius R.
• Primary Examiner(s): Alstrum Acevedo, James H
• Assistant Examiner(s): KASSA, JESSICA M
• Application Number:
  US13/294,234
• Publication Number:
  US 20120288461A1
• Time in Patent Office: 445 Days
• Field of Search: None
• US Class Current: 514/544
• CPC Class Codes: A61K 2800/31 Anhydrous
• CPC Class Codes: A61K 2800/43 Pigments; Dyes
• CPC Class Codes: A61K 2800/54 Polymers characterized by specific structures/properties
• CPC Class Codes: A61K 2800/591 Mixtures of compounds not provided for by any of the codes A61K2800/592 - A61K2800/596
• CPC Class Codes: A61K 2800/596 Mixtures of surface active compounds
• CPC Class Codes: A61K 31/05 Phenols cannabinoids A61K31/658
• CPC Class Codes: A61K 8/0241 Containing particulates characterized by their shape and/or structure see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes
• CPC Class Codes: A61K 8/062 Oil-in-water emulsions
• CPC Class Codes: A61K 8/064 Water-in-oil emulsions, e.g. Water-in-silicone emulsions
• CPC Class Codes: A61K 8/066 Multiple emulsions, e.g. water-in-oil-in-water
• CPC Class Codes: A61K 8/25 Silicon; Compounds thereof
• CPC Class Codes: A61K 8/347 Phenols
• CPC Class Codes: A61K 8/37 Esters of carboxylic acids
• CPC Class Codes: A61K 8/375 the alcohol moiety containing more than one hydroxy group
• CPC Class Codes: A61K 8/42 Amides
• CPC Class Codes: A61K 8/585 Organosilicon compounds
• CPC Class Codes: A61K 8/60 Sugars; Derivatives thereof
• CPC Class Codes: A61K 8/602 Glycosides, e.g. rutin
• CPC Class Codes: A61K 8/891 saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
• CPC Class Codes: A61K 8/9711 Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
• CPC Class Codes: A61K 8/9728 : Fungi, e.g. yeasts
• CPC Class Codes: A61K 8/9789 : Magnoliopsida [dicotyledons]
• CPC Class Codes: A61K 8/9794 : Liliopsida [monocotyledons]
• CPC Class Codes: A61Q 1/02 : Preparations containing skin colorants, e.g. pigments preparations in powder form A61Q1/12
• CPC Class Codes: A61Q 1/06 : Lipsticks
• CPC Class Codes: A61Q 1/08 : for cheeks, e.g. rouge
• CPC Class Codes: A61Q 1/10 : for eyes, e.g. eyeliner, mascara
• CPC Class Codes: A61Q 1/12 : Face or body powders for grooming, adorning or absorbing
• CPC Class Codes: A61Q 17/04 : Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/00 : Preparations for care of the skin
• CPC Class Codes: A61Q 19/007 : Preparations for dry skin
• CPC Class Codes: A61Q 19/08 : Anti-ageing preparations
• CPC Class Codes: C07C 69/017 : Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
• CPC Class Codes: C07C 69/30 : esterified with trihydroxylic compounds fats, oils C11B, C11C
• CPC Class Codes: C07C 69/604 : Polycarboxylic acid esters, the acid moiety containing more than two carboxyl groups
• CPC Class Codes: C07C 69/94 : of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings

Abstract

Ascorbic acid esters of resveratrol and topical compositions containing same.

Claims

1. A compound selected from the group consisting of:

3-ascorbate-5,4′

-dihydroxystilbene;

4′

-ascorbate-3,5-dihydroxystilbene;

3,5-diascorbate-4′

-hydroxystilbene;

3,4′

-diascorbate-5-hydroxystilbene;

3,5,4′

-triascorbate stilbene.

2. The compound of claim 1 which is 3-ascorbate-5,4′

-dihydroxystilbene.

3. The compound of claim 1 which is 4′

-ascorbate-3,5-dihydroxystilbene.

4. The compound of claim 1 which is 3,5-diascorbate-4′

-hydroxystilbene.

5. The compound of claim 1 which is 3,4′

-diascorbate-5-hydroxystilbene.

6. The compound of claim 1 which is 3,5,4′

-triascorbate stilbene.

7. A topical composition comprising a compound selected from the group consisting of:

3-ascorbate-5,4′

-dihydroxystilbene;

4′

-ascorbate-3,5-dihydroxystilbene;

3,5-diascorbate-4′

-hydroxystilbene;

3,4′

-diascorbate-5-hydroxystilbene;

3,5,4′

-triascorbate stilbene; and

mixtures thereof.

8. The composition of claim 7 wherein the compound is 3-ascorbate-5,4′

-dihydroxystilbene.

9. The composition of claim 7 wherein the compound is 4′

-ascorbate-3,5-dihydroxystilbene.

10. The composition of claim 7 wherein the compound is 3,5-diascorbate-4′

-hydroxystilbene.

11. The composition of claim 7 wherein the compound is 4′

,5-diascorbate-3-hydroxystilbene.

12. The composition of claim 7 wherein the compound is 3,5,4′

-triascorbate stilbene.

13. The composition of claim 7 in the form of an emulsion.

14. The composition of claim 7 in the form of an oil-in-water emulsion.

15. The composition of claim 7 further comprising at least one nonionic organic surfactant.

16. The composition of claim 7 which is a skin cream or lotion, foundation makeup, blush, concealer, eyeshadow, eyeliner, mascara, or lipstick.