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Foamable vehicle and pharmaceutical compositions thereof

  • US 8,362,091 B2
  • Filed: 04/26/2010
  • Issued: 01/29/2013
  • Est. Priority Date: 08/04/2003
  • Status: Active Grant
First Claim
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1. A foamable hygroscopic pharmaceutical composition in a pressurized container, the foamable hygroscopic pharmaceutical composition comprising:

  • i) a carrier composition comprising;

    a. at least one hygroscopic substance selected from the group consisting of;

    a polyethylene glycol (PEG) and a polyol at a sufficient concentration to provide an Aw value of the hygroscopic pharmaceutical composition of less than 0.9;

    b. about 0.01% to about 5% by weight of the carrier composition of a gelling agent; and

    c. 0% to about 25% by weight of the carrier composition of water; and

    ii) a liquefied or compressed gas propellant;

    wherein the foamable hygroscopic pharmaceutical composition forms a breakable foam upon release from the pressurized container;

    wherein the breakable foam does not immediately collapse upon exposure to skin temperature; and

    wherein the breakable foam breaks under shear force.

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