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Nanotubes as mitochondrial uncouplers

  • US 8,362,343 B2
  • Filed: 02/25/2011
  • Issued: 01/29/2013
  • Est. Priority Date: 05/06/2005
  • Status: Expired due to Fees
First Claim
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1. A pharmaceutical composition comprising nanotubes in a pharmaceutically acceptable carrier, wherein the pharmaceutical composition is suitable for administration to a subject by (i) intravenous delivery, (ii) ingestion, (iii) particle bombardment via a gene gun, or (iv) patch or gel application to the dermis, wherein the nanotubes are self-rectifying metal nanotubes, having a length of less than 50 nm and a conductance such that the nanotubes conduct protons only when a proton gradient of about 120-220 mV is present.

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