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Integrated biosensor and stimulation system for diagnosis and therapy

  • US 8,364,411 B2
  • Filed: 12/03/2007
  • Issued: 01/29/2013
  • Est. Priority Date: 08/22/2003
  • Status: Active Grant
First Claim
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1. A method for predicting therapeutic strategy in a biological system comprising the steps of:

  • accessing by a controller a data storage, wherein said controller is located within an implantable bionetwork biosensor apparatus comprising a sensor unit comprising a positioning chip and a biosensor platform;

    the controller comprising a network, a systems biology platform, a data storage, and a wireless communication unit;

    a therapeutic unit comprising a therapeutic manufacture, therapeutic reservoirs, and a sensor manufacture; and

    a power module coupled to the sensor unit, the controller, and the therapeutic unit;

    executing from one or more software tools stored within said data storage which represents one or more biological processes and molecular interactions as mathematical models;

    accessing by the controller the systems biology platform via the network to said stored software tools, wherein the systems biology platform comprises a computational biology simulator using reconfigurable emulation logic devices that access genomics database, transcriptomics database, proteomics database, metabolomics database, pharmacogenomics database, pharmacokinetics database, disease database and drug database;

    executing by the controller a set of simulations using said reconfigurable emulation logic devices pertaining to administration of a drug; and

    causing by the controller to generate a simulation report to predict outcome of the interactions of the biological system with the drug, thereby aiding in target discovery and validation.

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