Methods and apparatus for intraocular brachytherapy

• US 8,365,721 B2
• Filed: 08/27/2010
• Issued: 02/05/2013
• Est. Priority Date: 02/12/2004
• Status: Expired due to Fees

• Current Assignee: Oraya Therapeutics, Inc.
• Original Assignee: Neovista, Inc.
• Inventors: Larsen, Charles E., Hillstead, Richard A., Trip, Roelof, deJuan, Eugene, Humayun, Mark S., Fritz, Eberhard, Pintaske, Rainer, Willenkamp, Sabine, Phillipps, Gerd T.
• Primary Examiner(s): Matthews, Christine
• Application Number:
  US12/870,459
• Publication Number:
  US 20110004045A1
• Time in Patent Office: 893 Days
• Field of Search: 600 1- 8, 604/27, 250/516.1
• US Class Current: 128/3
• CPC Class Codes: A61N 5/1017 Treatment of the eye, e.g. for "macular degeneration"

Abstract

A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end. A positioning system for the cannula is also disclosed.

Claims

1. A radioactive source wire having a proximal end and distal end comprising:

a leading strand at the distal end having sufficient flexibility so as to allow unimpeded mechanical transport through a cannula around a radius of curvature of from 4 to 8 mm;

a handle strand at the proximal end having greater stiffness than the leading strand;

a tubular sleeve for securing the leading strand to the handle strand and secured to the leading strand and handle strand by welding;

a radioactive source comprising a canister holding a radioactive seed secured to the distal end of the leading strand;

a reinforcing sleeve at a junction of the canister and the leading strand for securing the canister to the leading strand; and

a reinforcing tubing at the proximal end of the handle strand.

2. A radioactive source wire having a proximal end and distal end comprising:

a leading strand at the distal end having sufficient flexibility so as to allow mechanical transport through a cannula around a radius of curvature of from 4 to 8 mm;

a proximal strand at the proximal end having greater stiffness than the leading strand;

a first reinforcing structure for securing the leading strand to the proximal strand and fixedly secured to the leading strand and proximal strand;

a radioactive source comprising a canister holding a radioactive seed secured to the a distal end of the leading strand;

a second reinforcing structure at a junction of the canister and the leading strand for securing the canister to the leading strand; and

a third reinforcing structure at a proximal end of the proximal strand.