Radiotherapy treatment monitoring using ultrasound
First Claim
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1. A method of assessing cell condition in response to treatment, the method comprising the steps of:
- a. obtaining a baseline ultrasound scan of a treatment area of a patient;
b. obtaining, subsequent to the baseline scan, one or more temporally distinct treatment ultrasound scans of the treatment area at various times during a course of treatment sessions;
c. comparing at least one of the one or more treatment ultrasound scans to the baseline ultrasound scan; and
d. based on the comparison, assessing cell condition in the treatment area in response to the treatment sessions, wherein the baseline ultrasound scan and the one or more treatment ultrasound scans are taken at a frequency below 20 MHz.
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Abstract
Methods and systems for assessing the effects of therapy on a patient include obtaining baseline and treatment ultrasound scans of a treatment area of a patient where the treatment ultrasound scans are taken subsequent to the baseline scan and at various times during a course of radiotherapy treatment sessions. The baseline and treatment ultrasounds are compared, and as a result a damage map representing cell death within the treatment area can be constructed.
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Citations
27 Claims
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1. A method of assessing cell condition in response to treatment, the method comprising the steps of:
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a. obtaining a baseline ultrasound scan of a treatment area of a patient; b. obtaining, subsequent to the baseline scan, one or more temporally distinct treatment ultrasound scans of the treatment area at various times during a course of treatment sessions; c. comparing at least one of the one or more treatment ultrasound scans to the baseline ultrasound scan; and d. based on the comparison, assessing cell condition in the treatment area in response to the treatment sessions, wherein the baseline ultrasound scan and the one or more treatment ultrasound scans are taken at a frequency below 20 MHz. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A system for determining cell condition in response to treatment, the system comprising:
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a storage unit configured to receive ultrasound scans of a treatment area, the ultrasound scans comprising; a baseline ultrasound scan; and one or more temporally distinct treatment ultrasound scans of the treatment area taken subsequent to the baseline scan and at various times during a course of treatment sessions, wherein the baseline ultrasound scan and the one or more treatment ultrasound scans are taken at a frequency below 20 MHz; and a comparator module configured to; (i) compare the baseline ultrasound scan and at least one of the one or more treatment ultrasound scans, and (ii) based on the comparison, determine cell condition in the treatment area in response to the treatment sessions. - View Dependent Claims (22, 23, 24)
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25. A non-transitory computer readable medium having computer-readable programs embodied thereon for determining cell condition in response to treatment, the medium comprising computer-readable instructions for:
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a. obtaining a plurality of temporally distinct ultrasound scans of a treatment area at various times during a course of treatment sessions, wherein the plurality of ultrasound scans are taken at a frequency below 20 MHz; b. comparing the plurality of ultrasound scans; and c. based on the comparison, determining cell condition in the treatment area in response to the treatment sessions. - View Dependent Claims (26, 27)
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Specification