Methods and apparatus for intracranial ultrasound delivery

• US 8,366,620 B2
• Filed: 04/30/2010
• Issued: 02/05/2013
• Est. Priority Date: 06/24/2005
• Status: Expired due to Fees

• Current Assignee: Penumbra, Inc.
• Original Assignee: Penumbra, Inc.
• Inventors: Nita, Henry
• Primary Examiner(s): Jung, Unsu
• Assistant Examiner(s): SHAHRESTANI, NASIR
• Application Number:
  US12/799,706
• Publication Number:
  US 20100222715A1
• Time in Patent Office: 1,012 Days
• Field of Search: 600/437, 600/439, 606/128, 604 20- 22
• US Class Current: 600/437
• CPC Class Codes: A61B 2017/22008 used or promoted
• CPC Class Codes: A61B 8/0808 for diagnosis of the brain
• CPC Class Codes: A61B 90/11 with guides for needles or instruments, e.g. arcuate slides or ball joints
• CPC Class Codes: A61N 2007/0047 interstitial
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092
• CPC Class Codes: A61N 7/022 intracavitary

Abstract

A method for delivering ultrasound energy to a patient'"'"'s intracranial space involves forming at least one hole in the patient'"'"'s skull, advancing at least one ultrasound delivery device at least partway through the hole(s), and transmitting ultrasound energy from the ultrasound delivery device(s). According to various embodiments, ultrasound delivery devices may be advanced into the epidural space, one or both ventricles and/or an intracerebral space of the patient'"'"'s brain. In alternative embodiments, one or multiple holes may be formed in the skull, and any number of ultrasound delivery devices may be used. Intracranial ultrasound delivery may be used in diagnostic or therapeutic treatment of ischemic stroke, head trauma, atherosclerosis, perfusion disorders and other acute or chronic neurological conditions.

Claims

1. A method for delivering ultrasound energy to a patient'"'"'s intracranial space, the method comprising:

forming at least one hole in the patient'"'"'s skull to access a target location;

placing an introducer device into the at least one hole to a treatment location within the target location;

advancing at least one ultrasound device having a distal portion through the introducer device, wherein the distal portion of the ultrasound device contains at least one transducer to allow transmission of ultrasound, and the distal portion can be moved to various locations within the intracranial space;

positioning the distal portion at a selected location within the intracranial space;

transmitting ultrasound energy at frequencies between 10 KHz and 10 MHz from the ultrasound device for therapeutic treatment; and

transmitting and directing the ultrasound energy to a blood clot in the patient'"'"'s brain at the target location that resides in an intracranial space of the patient'"'"'s brain, wherein the blood clot is located outside a blood vessel.

2. The method of claim 1, wherein the blood clot resides in the intracerebral location of the intracranial space.

3. The method of claim 1, wherein the blood clot resides underneath the dura mater located within the intracranial space.

4. The method of claim 1, wherein the blood clot resides in the epidural location of the intracranial space.

5. The method of claim 1, wherein advancing the at least one ultrasound device comprises advancing the device into the patient'"'"'s epidural space.

6. The method of claim 1, wherein advancing the at least one ultrasound device comprises advancing the device into at least one ventricle of the patient'"'"'s brain.

7. The method of claim 1, wherein advancing the at least one ultrasound device comprises advancing the device into an intracerebral space of the patient'"'"'s brain.

8. The method of claim 1, wherein advancing the at least one ultrasound device comprises advancing the device underneath the dura mater of the patient'"'"'s brain.

9. The method of claim 1, wherein advancing the ultrasound device comprises advancing a device selected from the group consisting of an ultrasound transducer and a transducer-tipped ultrasound catheter.

10. The method of claim 1, further comprising delivering at least one pharmacologic agent to the patient intracranial space.

11. The method of claim 1, further comprising delivering microbubbles or nanobubbles.

12. The method of claim 1, further including removing blood clots to the outside the head.