Drug releasing coatings for medical devices
First Claim
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1. A balloon catheter for delivering a therapeutic agent to a target site of a blood vessel, the balloon catheter comprising:
- an inflatable polyamide balloon; and
a coating layer that adheres to an exterior surface of the inflatable polyamide balloon,wherein;
the coating layer comprises a hydrophobic therapeutic agent and at least one water-soluble additive;
the hydrophobic therapeutic agent is selected from the group consisting of paclitaxel, rapamycin, everolimus, docetaxel, and combinations thereof;
the hydrophobic therapeutic agent is not enclosed in micelles or liposomes and is not encapsulated in polymer particles;
the at least one water-soluble additive comprises a PEG fatty ester selected from the group consisting of PEG glyceryl oleates, PEG glyceryl stearates, PEG sorbitan stearates, PEG sorbitan monolaurates, and PEG sorbitan monooleates;
the ratio by weight of the at least one additive to the therapeutic agent in the coating layer is from about 0.05 to 100.
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Abstract
The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. The additive has a hydrophilic part and a hydrophobic part and the therapeutic agent is not enclosed in micelles or encapsulated in particles or controlled release carriers.
465 Citations
17 Claims
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1. A balloon catheter for delivering a therapeutic agent to a target site of a blood vessel, the balloon catheter comprising:
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an inflatable polyamide balloon; and a coating layer that adheres to an exterior surface of the inflatable polyamide balloon, wherein; the coating layer comprises a hydrophobic therapeutic agent and at least one water-soluble additive; the hydrophobic therapeutic agent is selected from the group consisting of paclitaxel, rapamycin, everolimus, docetaxel, and combinations thereof; the hydrophobic therapeutic agent is not enclosed in micelles or liposomes and is not encapsulated in polymer particles; the at least one water-soluble additive comprises a PEG fatty ester selected from the group consisting of PEG glyceryl oleates, PEG glyceryl stearates, PEG sorbitan stearates, PEG sorbitan monolaurates, and PEG sorbitan monooleates; the ratio by weight of the at least one additive to the therapeutic agent in the coating layer is from about 0.05 to 100. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification