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Drug releasing coatings for medical devices

  • US 8,366,662 B2
  • Filed: 03/07/2011
  • Issued: 02/05/2013
  • Est. Priority Date: 11/20/2006
  • Status: Active Grant
First Claim
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1. A balloon catheter that delivers a therapeutic agent to a blood vessel, the balloon catheter comprising a coating layer overlying an exterior surface of an expandable inflatable balloon, wherein:

  • the coating layer is pressed into direct contact with a vessel wall of the blood vessel when the expandable inflatable balloon is inflated during balloon angioplasty and comprises a therapeutic agent and at least one additive;

    the therapeutic agent comprises paclitaxel;

    the at least one additive comprises gluconolactone and at least one surfactant selected from the group consisting of PEG laurates, PEG oleates, PEG stearates, PEG glyceryl laurates, PEG glyceryl oleates, PEG glyceryl stearates, PEG sorbitan laurates, PEG sorbitan palmitates, PEG sorbitan stearates, PEG sorbitan oleates, and combinations thereof;

    the ratio of the total weight of additive in the coating layer to the weight of the therapeutic agent in the coating layer is from about 0.05 to 100;

    the therapeutic agent is not enclosed in micelles or encapsulated in polymer particles; and

    the coating layer does not include an iodine covalent bonded contrast agent, an oil, or a lipid.

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